Comparative study on hepatoprotective activity of Pongamia pinnata (PP) & Annona squamosa (AS) leaf extracts against anti-tubercular drugs (isoniazid & rifampin) induced hepatotoxicity in rats

Samba Siva Raju Derangula; N. S. Muthiah; B. V. Surendra; K. Somasekhar Reddy; H. S. Somashekar; E. Sukumar; K. Prabhu

doi:10.53730/ijhs.v6nS2.5174

Authors

Samba Siva Raju Derangula
dssrajupharma@gmail.com
Ph.D. Scholar, Bharath Institute of Higher Education & Research, Selaiyur, Chennai, Tamilnadu, India
N. S. Muthiah Professor, Department of Pharmacology, Sree Balaji Medical College & Hospital, Chrompet, Chennai, Tamilnadu, India
B. V. Surendra Assistant Professor, Department of Physiology, Viswabharathi Medical College & Hospital, Kurnool, Andhra Pradesh, India
K. Somasekhar Reddy Associate professor & Head, Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education & Research, Anantapuramu, Andhra Pradesh, India
H. S. Somashekar Professor & Head, Department of Pharmacology, Viswabharathi Medical College & Hospital, Kurnool, Andhra Pradesh, India
E. Sukumar Ex-Dean of Research, Saveetha Institute of Medical & Technical Sciences, Chennai, Tamilnadu, India
K. Prabhu Associate Professor, Department of Anatomy, Sree Balaji Medical College & Hospital, Chrompet, Chennai, Tamilnadu, India

Keywords:

Pongamia pinnata, Annona squamosa, isoniazide, rifampin, silymarin, hepatoprotective

Abstract

Objectives: - The goal of this study is to compare the effects of Pongamia Pinnata and Annona Squamosa on anti-tubercular medicines-induced hepatotoxicity in rats. Materials and Procedures: - In rats, hepatotoxicity was caused by administering a suspension of isoniazid and rifampin orally for 21 days. Pongamia Pinnata and Annona Squamosa, as well as anti-tubercular medicines, were given to the treatment groups. Biochemical & histological criteria were used to measure liver destruction. Results: - The use of Pongamia Pinnata and Annona Squamosa in combination with anti-tubercular medicines dramatically reduced Serum Glutamate Pyruvic Transaminase (SGPT), Serum Glutamate Oxaloacetic Transaminase (SGOT)& tissue malondialdehyde (MDA) levels. Inflammation, degeneration, and necrotic alterations in hepatocytes were reduced. Pongamia Pinnata also reduced a drop in blood Superoxide Dismutase (SOD) when compared to a control group getting only anti-tubercular medicines. Pongamia Pinnata, on the other hand, had no statistically significant effects when compared to Annona Squamosa and silymarin. Conclusion: - Annona Squamosa was found to be an effective hepatoprotective agent in rats, as it considerably reduced the hepatotoxic damage caused by anti-tubercular medicines. However, when the effects of Pongamia Pinnata & Annona Squamosa or silymarin were compared, there was no statistically significant difference.

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