To fabricate and evaluate the wound healing activity of herbal medicated plasters containing the extracts obtained from Tridax procumbens and Azadirachta indica

Nikhil M. Satpute; Ravi Kalsait; Abhinav Bais; Narendra Dighade; Komal Meshram; Dhruba Hari Chandi

doi:10.53730/ijhs.v6nS2.5047

Authors

Nikhil M. Satpute
nsatpute02@gmail.com
Nagpur College of Pharmacy, Wanadongri, Hingna road, Nagpur-441110
Ravi Kalsait Datta Meghe Medical College, Shalinitai Meghe Hospital and Research Centre, Nagpur Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences Sawangi (Meghe) Wardha
Abhinav Bais Datta Meghe Medical College, Shalinitai Meghe Hospital and Research Centre, Nagpur Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences Sawangi (Meghe) Wardha
Narendra Dighade Datta Meghe Medical College, Shalinitai Meghe Hospital and Research Centre, Nagpur Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences Sawangi (Meghe) Wardha
Komal Meshram Datta Meghe Medical College, Shalinitai Meghe Hospital and Research Centre, Nagpur Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences Sawangi (Meghe) Wardha
Dhruba Hari Chandi Datta Meghe Medical College, Shalinitai Meghe Hospital and Research Centre, Nagpur Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences Sawangi (Meghe) Wardha

Keywords:

antimicrobial test, antioxidant study, coat button, neem, patch test, qualitative, quantitative test

Abstract

The present research work is to fabricate medicated plaster containing herbal extracts for wound healing properties. Till date no herbal medicated plaster have been prepared and evaluated using the extracts obtained from the plants Neem and Coatbutton. The objective of the present studyis to provide the herbal medicated plasters to the society. The majoradvantage of this medicated herbal plaster is its safety, efficacy, portability and efficiency. There is much more study such as Collection of plant, Extraction of plant materials and their antimicrobial test, Evaluation of qualitative and quantitative test, Estimation of total phenolic content, Antioxidant study, Antimicrobial study, Estimation of patch test, Antimicrobial studies of patch test. The plant extracts were quantitatively analysed for total flavonoids content, total phenolic content, and antioxidant activity. Methanolic extract of Azadirechta indica and Tridax procumbens has shown presence of high content of flavonoids and total phenolic content. Also the Azadirachtin content in the neem extracts was determined. All the six extracts AIME, AIPE, AIAE, TPME, TPPE and TPAE were subjected to antimicrobial activity.In patch test FII batch shows the excellent antimicrobial activity.FII patch was selected for fabrication of plasters which was then subjected to the pharmacological study.

Downloads

Download data is not yet available.

References

Allah Nawaz1, Kamran Alam1, Zeeshan Ahmed Sheikh1, Naseema Khatoon1, Syed Muhammad Amir, Khan Usmanghani and Irshad Ahmad:Design, development, and evaluation of antimicrobial activity of herbal antiseptic wound pad-neemplast. African Journal of Pharmacy and Pharmacology-2013,Vol. 7 (33) pg. no. 2341-2347

Amal Kumar Ghimeray1, Cheng-Wu Jin1, Bimal Kumar Ghimire2 and Dong Ha Cho: Antioxidant activity and quantitative estimation of azadirachtin and nimbin in AzadirachtaIndicaA. Juss grown in foothills of Nepal. African Journal of Biotechnology-2009 Vol. 8 (13), pg.no. 3084-3091.

Barua CC, Talukdar A, Barua AG, Chakraborty A, Sharma RK, Bora RS: Evaluation of the wound healing activity of methanolic extract of Azadirachtaindica(Neem) and Tinosporacordifolia(Guduchi) in rats. Pharmacol Online-2010,pg.no.1178-1182. .

Bharathi V., Varalakshmi B. , Gomathi S., A.Shanmuga Priya1, T.Karpagam Antibacterial activity of tridax.international journal of pharma sciences and research-2012 vol 3 pg.no.364-367.

Bijay Kumar Sahoo, AmiyaKanta Mishra: Formulation and evaluation of transdermal patchesof diclofenac. World Journal of Pharmacy and Pharmaceutical Sciences-2013 Volume 2, Issue 6 pg. no. 4965-4971.

Jr, B. F. P. ., & Federico R. Tewes. (2021). What attorneys should understand about Medicare set-aside allocations: How Medicare Set-Aside Allocation Is Going to Be Used to Accelerate Settlement Claims in Catastrophic Personal Injury Cases. Clinical Medicine and Medical Research, 2(1), 61-64. https://doi.org/10.52845/CMMR /2021v1i1a1

Binu Thomas, RajendranArumugam, AravindhanVeerasamy, SivalingamRamamoorthy:Ethnomedicinal plants used for the treatment of cuts and wounds by Kurumatribes, Wayanadu districts of Kerala, India. Asian Pacific Journal of Tropical Biomedicine- 2014 pg no. S488-S491.

Clark RA, editor. Wound repair: Overview and general considerations. In: The Molecular and Cellular Biology of Wound Repair. New York: Plenum-1996. Pg.no 3-50.

Daniel, V. ., & Daniel, K. (2020). Diabetic neuropathy: new perspectives on early diagnosis and treatments. Journal of Current Diabetes Reports, 1(1), 12–14. https://doi.org/10.52845/JCDR/2020v1i1a3

Ehrlich HP, Hunt TK.: The effect of cortisone and anabolic steroids on the tensile strength of healing wounds. Annual Surgery. 1968, 57, 117-121.

Frank SD: Amelio‘ Sr Botanical A phytocosmetics desk reference 1999 by CRC press LLC pg.no. 216.

Habib and Rahim., Antimicrobial Activity of Methanolic Neem Extract on Wound Infection Bacteria, International Conference on Biological, Chemical and Environmental Sciences-2014 pg.no.72-75.

Daniel, V., & Daniel, K. (2020). Perception of Nurses’ Work in Psychiatric Clinic. Clinical Medicine Insights, 1(1), 27-33. https://doi.org/10.52845/CMI/20 20v1i1a5

Harborne J.B. “Phytochemical methods – a guide to modern techniques of plant analysis”. 2nded. New York: Chapman and Hall, 1984.

Hemalata S, Subramanian N, Ravichandran V, Chinnaswamy K.: Wound healing activity of Indigoferaennaphylla Linn. Indian Journal of Pharmaceutical Sciences. 2001, 63, 331–333.

Imam Hashmat1, Hussain Azad and Ajij Ahmed: Neem (Azadirachta indica A. Juss) - A Nature's Drugstore: An overview. International Research Journal of Biological Sciences-2012 Vol. 1(6),pg.no. 76-79.

Jeffery MD. Experimental animal models.Wounds 2001 Vol 13(1) pg.no 9-23.

Kale V, Bhusari K: Practical Microbiology Principles &Techniques, Himalaya publication House-2001,Edition(1)pg no. 8-10.

KarpagavalliL, MahaeswaranA, PraveenaP, SharmilaS, PriyaM, MeenaB: Formulation and Evaluation of Transdermal Patches of Curcumin. International journal of novel trends in pharmaceutical sciences-2017. vol. 7 pg.no. 24-26.

Khandelwal K.R, Kokate C.K, Purohit A.P, Gokhale S.B. “Practical Pharmacognosy”. 3rd ed. Pune: NiraliPrakashan, 1996.

Daniel, V., & Daniel, K. (2020). Exercises training program: It’s Effect on Muscle strength and Activity of daily living among elderly people. Nursing and Midwifery, 1(01), 19-23. https://doi.org/10.52845/NM/2020v1i1a5

Majmudar H , Mourya V 1, Devdhe S2, Chandak R 3Pharmaceutical Applications of Ispaghula Husk: Mucilage International Journal of Pharmaceutical Sciences Review and Research-2013Vol(1), pg.no 49-55.

Maksimovic Z, Malenc D, Kovac N. : Polyphenol contents and antioxidant activity of Maydis stigma extracts . BioresourcesTechnology , 2005, 873-877.

Maragathavalli, S., 2Brindha, S., 3Kaviyarasi, N.S., 4B. Annadurai, B. & 5Gangwar, S.K.: Antimicrobial activity in leaf extract of neem (Azadirachtaindicalinn.).International journal of science and nature- 2012 VOL. 3(1)pg.no. 110-113.

Mukherjee P.K. “Quality Control of Herbal Drugs – an approach to evaluation of Botanicals”. 1sted. Business Horizons Pharmaceutical Publications, New Delhi; 2002.

Nadkarni KM: Indian materiamedica. Popular prakashan, Mumbai, Edition 3,vol.II –III, pg no. 294

NageshH. N.,.BasavannaP. L, KishoreM. S.: Evaluation of wound healing activity of ethanolic extract of Azadirachta Indica leaves on incision and excision wound models in Wister albino rats.International Journal of Basic & Clinical Pharmacology- 2015 Vol 4 Issue 6 Pg.no. 1178-1182.

Nilani P., Pranavi A., Duraisamy B., Damodaran P., Subhashini V. and Elango K: Formulation and evaluation of wound healing dermal patch. African Journal of Pharmacy and Pharmacology 2011; Vol. 5(9), pg.no. 1252-1257.

OECD 423. Revised Document (Oct-2000) Guidance document on acute oral toxicity. Guidelines for the testing of chemicals. Annexure-2.

Ajonish Kamble, Ranjit S. Ambad, Mangesh Padamwar, Anupam Kakade, Meenakshi Yeola. To study the effect of oral vitamin D supplements on wound healing in patient with diabetic foot ulcer and its effect on lipid metabolism. Int. J. Res. Pharm. Sci., 2020, 11(2), 2701-2706.

Pawar R.S., Chaurasiya P.K., Rajak H,Singour P.K., FedelicT.P., and Jain A.: Wound healing activity of Sidacordifolia Linn. in rats . Indian Journal of Pharmacology. 2013 , 45(5), 474–478.

Ramya R, Dhamotharan R: Qualitative and Quantitative Analysis of Phytochemicals of CostusSpeciosus.International Journal of Health Sciences & Research 2015; Vol.5, pg.no. 170- 176.