Synthesis of some thiazolidine-4-one derivatives of Isoniazid by using the microwave method and evaluation of their antibacterial and antifungal activity

Ahmed Yassin Taha; Malath Khalaf Rasheed

doi:10.53730/ijhs.v6nS1.5234

Authors

Ahmed Yassin Taha Department of Chemistry - College of Education - University of Samarra – Iraq
Malath Khalaf Rasheed Department of Chemistry - College of Education - University of Samarra – Iraq

Abstract

In this research, several Schiff bases [A1-A5] were prepared by reacting isoniazid with some aldehydes such as (4-hydroxybenzaldehyde, 3-nitro-4-hydroxybenzaldehyde, 4,3-dichlorobenzaldehyde, 4-hydroxy-3,5-dimethoxybenzaldehyde, pyrrole -2-carbaldehyde) by microwave method. In the same way, some ketones such as (Isatin and 4-aminoacetophenone) were used with Isoniazid to prepare Schiff bases [A6, A7]. Derivatives of thiazolidine-4-one (A8-A14) were prepared through the reaction of Schiff bases [A1-A7] with thioglycolic acid using dry benzene as a solvent and the reaction was done by microwave device. The prepared compounds were identified by infrared spectroscopy, mass spectrometry, and nuclear magnetic resonance spectrometry as well as the change in color and melting point. The results of the biological activity of the prepared compounds showed high inhibitory activity at concentrations of 5, 10, and 15 mg/ml against the fungus Aspergillus sp. and against two types of bacteria isolates, GVe+ Streptococcus pneumonia, and GVe- Pseudomonas aeruginous, and the results were compared with the standard antibiotics Nystatin, Isoniazid l and Sulfamethoxazole.

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