Synthesis and identification of benzo[d][1,3]oxazin-4-one derivatives and testing of antibacterial activity of some of them

Mohamed Hussin Khalaf; Malath Khalaf Rasheed

doi:10.53730/ijhs.v6nS2.7666

Authors

Mohamed Hussin Khalaf
us4010520014@uosamarra.edu.iq
Department of Chemistry, College of Education, University of Samarra, Samarra, Iraq
Malath Khalaf Rasheed Department of Chemistry, College of Education, University of Samarra, Samarra, Iraq

Keywords:

methylenedianiline, Schiff bases, microwave

Abstract

Schiff bases (M1-M9) were prepared from a reaction of 4,4-methylenedianiline (MDA) 4,4-Methylenedianiline with aldehydes (2-bromobenzaldehyde, 2-chlorobenzaldehyde, benzaldehyde and 4-methoxy benzaldehyde) were prepared by microwave irradiation. Schiff bases (M10-M18) were reacted Prepared in the previous paragraph with salicylic acid to prepare 4,3-dihydro-1,3 -oxazine-4-one derivatives by microwave method. Nuclear magnetic resonance and infrared spectroscopy, as well as physical changes such as melting points and color change, were used to diagnose the produced compounds. Some of the prepared compounds were tested against two types of bacterial isolates, Staphylococcus aureus gram-positive and Klebsiella pneumonia gram-negative. The results showed the antibacterial activity of these compounds, at different concentrations (5,10,15) mg/ml against this bacterium compared with antibiotic ciprofloxacin. Some compounds, including the compound M5, showed good activity against Staphylococcus aureus, and some were moderately effective against Klebsiella pneumonia.

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