Synthesis, characterization and antibacterial activity of thiazolidine-4-one and imidazolidine-4-one derived from Mesalazine drug by microwave method

Abdullah Khalid Shehab; Malath Khalaf Rasheed

doi:10.53730/ijhs.v6nS1.8088

Authors

Abdullah Khalid Shehab Department of Chemistry, College of Education, University of Samarra, Samarra, Iraq
Malath Khalaf Rasheed Department of Chemistry, College of Education, University of Samarra, Samarra, Iraq

Keywords:

Mesalazine, thiazolidine-4-one, imidazolidine-4-one, antibacterial

Abstract

The Schiff bases (A1- A5) were produced from the reaction of the 5-aminosalicylic acid with a variety of aldehydes by microwave method. Schiff bases were reacted with thioglycolic acid to obtain thiazolidine-4-one compounds (A6 – A10). Imidazolidine-4-one compounds (A11 - A15) were prepared from the prepared Schiff bases with the amino acid (alanine). Spectroscopic methods were used to diagnose the produced compounds (IR, ¹H-NMR). The biological activity against two types of bacteria Proteus mirabilis –GVe and Enterococcus faecalis +GVe have tested and compared with the Mesalazine drug. The results proved that some of the prepared compounds are effective against these bacteria at different concentrations of 5 mg/ml, 10 mg/ml, and 15 mg/ml.

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