Evaluation of hepatoprotective effect of Withania somnifera and Rubia cordifolia against carbon tetrachloride induced hepatotoxicity in albino rats

P.A Aboobecker Siddique; Anand Gaur; Anurag Bajpai; Abhay John

doi:10.53730/ijhs.v6nS4.5693

Evaluation of hepatoprotective effect of Withania somnifera and Rubia cordifolia against carbon tetrachloride induced hepatotoxicity in albino rats

https://doi.org/10.53730/ijhs.v6nS4.5693

Authors

Aboobecker Siddique P.A Assistant Professor, Department of Pharmacology
Anand Gaur Assistant Professor, Department of Pharmacology, N. C Medical College & Hospital, Israna, Panipat, Haryana
Anurag Bajpai Professor and HOD, Department of Pharmacology, N. C Medical College & Hospital, Israna, Panipat, Haryana
Abhay John Associate Professor, Department of Pharmacology, Amaltas Institute of Medical Science, Dewas

Keywords:

hepatoprotective, withania somnifera, rubia cordifolia

Abstract

Liver is one of the largest gland of the body and the main site for intense metabolism and excretion. Liver is concerned with metabolism of endogenous as well as exogenous substances. “Withania somnifera” and “Rubia cordifolia” claim to have hepatoprotective action. Till now, no scientific study has been performed to evaluate such claims. This was an experiment study conducted on wistar rats, in Department of Pharmacology, Index Medical College. Healthy Albino wistar rats of either gender, weighing 150- 200g were obtained from CPCSEA approved Central Animal House. The selected rats were housed in polpropylene cages under controlled conditions of temperature (25 ⁰C) and alternating periods of light and darkness of 12 hours each. The rats had free access to standard rat pellet diet and tap water ad libitum. After one week of acclimatization, the animals were rendered suitable for study. Pregnant female rats were not included in the study. ALT level in normal saline treated group was 29.5±3.35 IU/L. It was found to be significantly increased (p<0.001) with administration of CCl₄ to 433.5±48.67 IU/L.

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Published

08-04-2022

How to Cite

Aboobecker Siddique, P., Gaur, A., Bajpai, A., & John, A. (2022). Evaluation of hepatoprotective effect of Withania somnifera and Rubia cordifolia against carbon tetrachloride induced hepatotoxicity in albino rats. International Journal of Health Sciences, 6(S4), 774–788. https://doi.org/10.53730/ijhs.v6nS4.5693

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Issue

Vol. 6 No. S4 (2022)

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Peer Review Articles

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