Effect of oxidative stress markers in breast carcinoma patients: A comparative cross sectional study in tertiary care hospital, Madya Pradesh, India

Nethala Ravi Kumar; Abhay John; Md Masood Ahmed Shareef; Siddharth D. Pimpalkar

doi:10.53730/ijhs.v6nS6.12727

Authors

Nethala Ravi Kumar
ravikumarnethala3@gmail.com
PhD Scholar, Department of Pharmacology, Index Medical College, Indore, Madhya Pradesh, India
Abhay John Associate Professor, Department of Pharmacology, Index Medical College, Indore, Madhya Pradesh, India
Md Masood Ahmed Shareef Associate Professor, Department of Biochemistry, Government Medical College, Suryapet Telangana, India
Siddharth D. Pimpalkar Associate Professor, Department of Microbiology, BRLSABVM Medical College, Rajnandgaon, Chattisgarh, India

Keywords:

oxidative stress markers, MDA, TAC, glutathione, breast carcinoma

Abstract

Background: Curiosity in view of the literature regarding breast cancer especially in our country, there has been little study on breast cancer individuals during and progression of the cancer on oxidative stress markers. Aim: To determine the effect of MDA, TAC, SOD, Catalase, reduced glutathione in breast cancer subjects and to compare them with the apparently healthy controls. Methods: Lately diagnosed female subjects with breast cancer in the age group of 40-60 years were included in the study. Apparently healthy controls were selected from the group of people who were attending for annual health check-up and found to be healthy. Results: On comparison between the two groups, the present study observed significant differences in the values of MDA, TAC, and reduced glutathione. Interestingly, we observed higher levels of MDA in the subjects suffering with breast carcinoma, whereas lower levels in the apparently healthy controls incorporated in the study. Comparing between the groups of LDL and HDL level, the present study observed significant difference. Conclusion: The present study concludes that alterations in the study parameters in breast cancer group are due to dys-balance oxidants production and lower expression of antioxidants.

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