Antidiabetic and hypolipidemic effects of fenugreek in Prediabetic subjects with dietary modifications

Syama Kumar Addepalli; Dupaguntla Rajesh; D. Bhavika; Nethala Ravi Kumar; Suresh Babu Sayana; Meela Ranjith Kumar

doi:10.53730/ijhs.v6nS6.12344

Authors

Syama Kumar Addepalli Assistant Professor, Department of Pharmacology, GITAM Institute of Medical Sciences and Research, GITAM Deemed to be University, Visakhapatnam, Andhra Pradesh, India
Dupaguntla Rajesh Assistant professor, Department of Pharmacology, Government Medical College (RIMS), Ongole, Andhra Pradesh, India
Bhavika D. Assistant professor, Department of Pharmacology, Government Medical College, Nalgonda, Telangana, India
Nethala Ravi Kumar
ravikumarnethala3@gmail.com
Assistant professor, Department of Pharmacology, BRLSABVM Medical College, Rajnandgaon, Chattisgarh, India
Suresh Babu Sayana Assistant Professor, Department of Pharmacology, Government Medical College and Hospital, Suryapet, Telangana, India
Meela Ranjith Kumar Tutor, Department of Pharmacology, Government Medical College and Hospital, Suryapet, Telangana, India

Keywords:

glycosylated haemoglobin/HbA1c, prediabetics, fenugreek, diet modification, lipid profile, TG, HDL, LDL, VLDL

Abstract

Objectives: The incidence of Diabetes Mellitus in India is growing day by day. Hyperlipidemia is also a major cause of health complication. Trigonella-foenum-graecum is one of the medicinal plants used in the management of Diabetes and Hyperlipidemia. The present study was conducted to assess the effect of fenugreek and dietery modification on HbA1c and on lipid profile. Materials and Methods: A Total of 280 prediabetics were included in the study. Patients were randomized and one group of patients receive 10 gm of fenugreek powder in hot water every day, while the second group did not receive. The parameters were assessed on the first visit and every 3months for 12 months. Results: HbA1c and Lipid profiles were analyzed, Dietary addition of fenugreek cause reduction in blood glucose and cholesterol levels. Conclusion: Conclusion: The present study showed that the administration of Trigonella-foenum-graecum seed powder had pronounced effects in improving lipid profile and prevents the T2DM progression from prediabetes with no adverse effects. Therefore, Fenugreek improved the lipid profile and act as a hypocholesterolemic by reducing the LDLc levels. Dietary addition of fenugreek can have a synergistic effect along with diet control on HbA1c and lipid profile.

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