Relationship between spermatogenesis, DNA fragmentation index, and teratozoospermia index
Keywords:
male infertility, spermatogenesis, sperm DNA fragmentation, teratozoospermia indexAbstract
Infertility has proven a global medical issue, with 15-20 percent of married worldwide experiencing difficulties in conceiving. One of the causes of male infertility is sperm morphology abnormalities, or teratozoospermia, which is often associated with sperm DNA damage. Teratozoospermia can increase sperm DNA fragmentation through several mechanisms, including abortive apoptosis and induce ROS formation. Unfortunately, many forms of sperm flaws, including genetic defects, could not be validated by routine semen examination. In the Sixth Edition, WHO introduced a more thorough sperm morphology examination, named the teratozoospermia index (TZI), in which every aberrant sperm is examined for up to four defects. Analyzing spermatozoa abnormalities in more detail can provide an overview of the function of the male reproductive organs, particularly the testes and epididymis. However, using this method is not entirely easy due to subnormal variations between cells so that quality control may be needed when using TZI for sperm morphology evaluation.
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References
Abdel Azim, AF, Ibrahim, MA, El-Abd, AM, Mostafa, MM and Elshafei, AIA, 2020. Effect of Varicocelectomy on Sperm DNA Fragmentation. Benha Journal of Applied Sciences, 5(6 part (1)), pp.7-17.https://journals.ekb.eg/article_137113.html
Ammar, O., Haouas, Z., Hamouda, B., Hamdi, H., Hellara, I., Jlali, A., Cheikh, HB and Mehdi, M., 2019. Relationship between sperm DNA damage with sperm parameters, oxidative markers in teratozoospermia men. European Journal of Obstetrics & Gynecology and Reproductive Biology, 233, pp.70-75.https://www.sciencedirect.com/science/article/pii/S0301211518311254
Ammar, O., Mehdi, M. and Muratori, M., 2020. Teratozoospermia: Its association with sperm DNA defects, apoptotic alterations, and oxidative stress. Andrology, 8(5), pp. 1095-1106.https://onlinelibrary.wiley.com/doi/abs/10.1111/andr.12778
Ammar, O., Mehdi, M., Tekeya, O., Neffati, F. and Haouas, Z., 2019. There is a novel association between apoptotic sperm biomarkers with seminal biochemical parameters and acetylcholinesterase activity in patients with teratozoospermia. Journal of Assisted Reproduction and Genetics, 36(11), pp.2367-2378.https://link.springer.com/article/10.1007/s10815-019-01579-7
Arumugam, M., Shetty, DP, Kadandale, JS and Nalilu, SK, 2019. Association of sperm aneuploidy frequency and DNA fragmentation index infertile men. Journal of Reproduction & Infertility, 20(3), p.121.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6670261/
Atshan, M., Kakavand, K., Hosseini, SH, Sadighi Gilani, MA, Mohseni Meybodi, A., and Sabbaghian, M., 2020. Evaluation of sperm DNA fragmentation and chromatin structure in infertility men with immotile short‐tail sperm defects. Andrologia, 52(1), p.e13445.https://onlinelibrary.wiley.com/doi/abs/10.1111/and.13445
Auger, J. 2010. Assessing human sperm morphology: top models, underdogs or biometrics? Asian journal of andrology. 12(1):36. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739679/
Bin Azizan, AS, 2018. Sperm DNA fragmentation comparison between smokers and non-smokers as measured by sperm chromatin dispersion test (Master's thesis, Kuantan, Pahang: International Islamic University Malaysia, 2018).http://studentrepo.iium.edu.my/handle/123456789/5736
Boeri*, L., Capogrosso, P., Cazzaniga, W., Ventimiglia, E., Pozzi, E., Belladelli, F., Alfano, M., Filippo, P., Abbate, C., Mirone, V. and Montanari, E., 2020. Mp26-03 The Relationship Between Isolated Teratozoospermia, Sperm DNA Fragmentation and Inflammatory Biomarkers: Findings from A Cross-Sectional Study. The Journal of Urology, 203(Supplement 4), pp. e400-e401.https://www.auajournals.org/doi/abs/10.1097/JU.0000000000000865.03
Candela, L., Boeri, L., Capogrosso, P., Cazzaniga, W., Pozzi, E., Belladelli, F., Baudo, A., Ravizzoli, A., Ventimiglia, E., Viganò, P. and Alfano, M., 2021. Correlation among isolated teratozoospermia, sperm DNA fragmentation and markers of systemic inflammation in primary infertility. Plos one, 16(6), p.e0251608.https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0251608
Cho, C.L., Esteves S.C., and Agarwal A. 2016. Novel insights into the pathophysiology of varicocele and its association with reactive oxygen species and
sperm DNA fragmentation. Asian J Androl, 18, pp.186-193. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770484/pdf/AJA-18-186.pdf
Chopra, S., Varma, A., Jain, S., Jain, S., and Choudhary, D., 2021. Effect of Sperm DNA Fragmentation Index on Clinical Outcomes of Intra-Uterine Insemination Patients. Biomedical and Pharmacology Journal, 14(3), pp. 1297-1305.https://onlinelibrary.wiley.com/doi/abs/10.1111/and.14322
Coutton, C., Escoffier, J., Martinez, G., Arnoult, C., Ray, P.F. 2015. Teratozoospermia: spotlight in the main genetic actors in the human. Hum Reprod Update, 21(4), pp. 455-485. https://academic.oup.com/humupd/article/21/4/455/684509
Das, SK and Kalita, K., 2022. Effect of sperm DNA fragmentation on blastocyst formation rate and subsequent IVF outcome. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 11(2), pp. 385-390.https://go.gale.com/ps/i.do?id=GALE%7CA693527589&sid=googleScholar&v=2.1&it=r&linkaccess=abs&issn=23201770&p=AONE&sw=w
De Braekerleer, M., Nguyen M.H., Morel, F., Perrin, A. 2015. Genetic aspects of monomorphic teratozoospermia: a review. J Assist Reprod Genet, 32(4), pp. 615-23. https://pubmed.ncbi.nlm.nih.gov/25711835/
Derbel, R., Sellami, H., Sakka, R., Slima, AB, Mkaddem, I., Gdoura, R., Mcelreavey, E. and Ammar-Keskes, L., 2021. Relationship between nuclear DNA fragmentation, mitochondrial DNA damage and standard sperm parameters in spermatozoa of infertile patients with leukocytospermia. Journal of Gynecology Obstetrics and Human Reproduction, 50(5), p.102101.https://www.sciencedirect.com/science/article/pii/S246878472100043X
Gatimel, N., Moreau, J., Parinaud, J., Leandri, RD. 2017. Sperm morphology: assessment, pathophysiology, clinical relevance, and state of the art in 2017. 5(5), pp. 845-862. Sperm morphology: assessment, pathophysiology, clinical relevance, and state of the art in 2017 - Gatimel - 2017 - Andrology - Wiley Online Library
Ganeva, R., Parvanov, D., Velikova, D., Vasileva, M., Nikolova, K. and Stamenov, G., 2021. Sperm morphology and DNA fragmentation after zona pellucida selection. Reproduction and fertility, 1(aop).https://raf.bioscientifica.com/view/journals/raf/aop/raf-21-0041/raf-21-0041.xml
Han, B., Wang, L., Yu, S., Ge, W., Li, Y., Jiang, H., Shen, W. and Sun, Z., 2021. An in-depth integrative analysis of multiple microarray data identified one potential biomarker for teratozoospermia. Aging (Albany NY), 13(7), p.10208.https://www.ncbi.nlm.nih.gov/pmc/articles/pmc8064145/
Jakubik-Uljasz, J., Gill, K., Rosiak-Gill, A. and Piasecka, M., 2020. Relationship between sperm morphology and sperm DNA dispersion. Translational Andrology and Urology, 9(2), p.405.https://www.ncbi.nlm.nih.gov/pmc/articles/pmc7215007/
Kaewman, P., Nudmamud-Thanoi, S., Amatyakul, P., and Thanoi, S., 2021. High mRNA expression of GABA receptors in human sperm with oligoasthenoteratozoospermia and teratozoospermia and its association with sperm parameters and intracytoplasmic sperm injection outcomes. Clinical and Experimental Reproductive Medicine, 48(1), p.50.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943344/
Khamar, T., Narooie-Nejad, M., Kordi, L. and Farzaneh, F., 2020. Frequency of Sperm DNA Fragmentation Index in Infertile Couples with Male Factor Infertility. Crescent Journal of Medical and Biological Sciences, 7(4), pp. 560-563.https://www.sid.ir/FileServer/JE/GHA50003620200401
Lasiene, K. 2018. Assessment of Human Sperm Cells Morphological Parameters. In: Spermatozoa - Facts and Perspectives. InTech. https://www.intechopen.com/chapters/57404
Maia, MM, 2020. Semen parameters, DNA fragmentation, and sperm aneuploidy evaluation in the etiology of male infertility.https://repositorio-aberto.up.pt/bitstream/10216/132044/2/441739.pdf
Maree, L., du Plessis, SS., Menkveld, R., van der Horst, G. 2020. Morphometric dimensions of the human sperm head depend on the staining method used. Human Reproduction. 25(6), pp.1369–82. https://academic.oup.com/humrep/article/25/6/1369/2915772?login=true
Mbaye, MM, El Khalfi, B., Zakaria, A., Louanjli, N., Zakaria, M. and Soukri, A., 2021. The Interest of Circulating DNA in the Management of Infertility, Especially in Men. J Fertil In vitro IVF Worldw Reprod Med Genet Stem Cell Biol, 9(4).https://www.researchgate.net/profile/Mustafa-Zakaria/publication/353779670_The_Interest_of_Circulating_DNA_in_the_Management_of_Infertility_Especially_in_Men/links/61118bff169a1a0103eb08ce/The-E-Interest-of-Circulating-DNA. pdf
Mehrparvar, B., Chashmniam, S., Nobakht, F., Amini, M., Javidi, A., Minai-Tehrani, A., Arjmand, B., and Gilany, K., 2020. Metabolic profiling of seminal plasma from teratozoospermia patients. Journal of pharmaceutical and biomedical analysis, 178, p.112903.https://www.sciencedirect.com/science/article/pii/S0731708519318692
Opuwari, CS, Henkel, RR and Agarwal, A., 2019. Sperm DNA Fragmentation Index. Recurrent pregnancy loss, pp.45-53. https://books.google.com/books?hl=en&lr=&id=PK52DwAAQBAJ&oi=fnd&pg=PA45&dq=Relationship+between+spermatogenesis,+DNA+Fragmentation+index+and+Teratozoospermic+index&ots=wwnvvggzzHL&sig=C2xlgzz
Panner Selvam, MK, Sengupta, P., and Agarwal, A., 2020. Sperm DNA fragmentation and male infertility. In Genetics of male infertility (pp. 155-172). Springer, Cham.https://link.springer.com/chapter/10.1007/978-3-030-37972-8_9
Saito, M., Tatsumi, T., Nakasuji, T., Ibayashi, M., Harada, T., Mutoh, T., Ito, C., Komiya, A., Hiraoka, K. and Kawai, K., 2020. Successful pregnancy and delivery achieved following intracytoplasmic sperm injection using teratozoospermia sperm exhibiting marked dysplasia of the fibrous sheath: a case report. Translational andrology and urology, 9(2), p.800.https://www.ncbi.nlm.nih.gov/pmc/articles/pmc7215008/
Sakhil, HAA, Rahim, AI and Abd Hussein, LA, 2021. What is the relationship between Sperm DNA integration and Sperm chromatin condensation and their Relation to sperm parameters? Annals of the Romanian Society for Cell Biology, 25(6), pp.17590-17595.https://www.annalsoffrscb.ro/index.php/journal/article/download/9089/6644
Santi, D., Spaggiari, G. and Simoni, M., 2018. Sperm DNA fragmentation index as a promising predictive tool for male infertility diagnosis and treatment management–meta-analyses. Reproductive biomedicine online, 37(3), pp.315-326.https://www.sciencedirect.com/science/article/pii/S1472648318303523
Shi, X., Chan, DYL, Zhao, MP, Chan, CPS, Huang, J., and Li, TC, 2019. Comparison of DNA fragmentation levels in spermatozoa with different sex chromosome complements. Reproductive Biomedicine Online, 38(1), pp.56-65.https://www.sciencedirect.com/science/article/pii/S1472648318305698
Siddhartha, N., Reddy, NS, Pandurangi, M., Muthusamy, T., Vembu, R. and Kasinathan, K., 2019. The effect of sperm DNA fragmentation index on the outcome of intrauterine insemination and intracytoplasmic sperm injection. Journal of Human Reproductive Sciences, 12(3), p.189.https://go.gale.com/ps/i.do?id=GALE%7CA680407428&sid=googleScholar&v=2.1&it=r&linkaccess=abs&issn=09746242&p=AONE&sw=w
Tinjić, S. and Ibrišimović, M., 2019. The introduction of a routine sperm DNA fragmentation test is a significant help in evaluating male fertility potential. Asian Journal of Science and Technology, 10(10), pp.10407-10410.https://www.researchgate.net/profile/Mirza-Ibrisimovic/publication/337447100_introduction_of_a_routine_sperm_dna_fragmentation_test_as_a_significant_help_in_evaluating_male_fertility_potential/links/5dd81-e5e92851c1-feda73f58/a-introductiontestine evaluating-male-fertility-potential.pdf
Wang, QX, Wang, X., Yu, MY, Sun, H., Wang, D., Zhong, SP and Guo, F., 2022. Random sperm DNA fragmentation index is not associated with clinical outcomes in day-3 frozen embryo transfer. Asian Journal of Andrology, 24(1), p.109.https://www.ajandrology.com/article.asp?issn=1008-682X;year=2022;volume=24;issue=1;spage=109;epage=115;aulast=Wang
Wang, YY, Lai, TH, Chen, MF, Lee, HL, Kuo, PL and Lin, YH, 2019. SEPT14 mutations and teratozoospermia: genetic effects on sperm head morphology and DNA integrity. Journal of clinical medicine, 8(9), p.1297.https://www.mdpi.com/521108
Xie, J., Yu, J., Fan, Y., Zhao, X., Su, J., Meng, Y., Wu, Y., Uddin, MB, Wang, C. and Wang, Z., 2020 Low dose lead exposure at the onset of puberty disrupts spermatogenesis-related gene expression and causes abnormal spermatogenesis in mouse. Toxicology and Applied Pharmacology, 393, p.114942.https://www.sciencedirect.com/science/article/pii/S0041008X20300661
Yang, H., Li, G., Jin, H., Guo, Y. and Sun, Y., 2019. The effect of sperm DNA fragmentation index on assisted reproductive technology outcomes and its relationship with semen parameters and lifestyle. Translational andrology and urology, 8(4), p.356.https://www.ncbi.nlm.nih.gov/pmc/articles/pmc6732090/
World Health Organization. 2021. WHO Laboratory Manual for the Examination and Processing of Human Semen 6th Edition.
Zhou, W.J., Huang, C., Jiang, S.H., Ji, X.R., Gong, F., Fan, L.Q., et al. 2021. Influence of sperm morphology on pregnancy outcome and offspring in in vitro fertilization and intracytoplasmic sperm injection, a matched case-control study. Asian J Androl, 23(4), pp. 421-428. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269829/
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