Preliminary report of profile FSH and LH of the COVID-19 survivors in Surabaya, Indonesia
Keywords:
gonadotropins, pneumonia confirmed COVID-19, initial research, Surabaya IndonesiaAbstract
Endocrine dysfunction in COVID-19 plays a role in clinical issues related to different disorders, including, hypogonadism, anxiety, stress and depression. Hypogonadism as an essential determinant for COVID-19-related pathogenesis which regulates the link between the brain and testes. In Indonesia, there is no studying about FSH and LH in COVID-19 survivors. Research design was cross sectional. We conducted this study at the Department of Biomedical Science Faculty of Medicine,, Universitas Airlangga Surabaya, Indonesia. A total of 34 male participants that recovery from COVID-19 enrolled, only 18 participants meet the criteria included. We conducted anamnesis, physical examination including height, weight, waist circumference and we analyzed hormone by using immunoflouroscene analyzer VIDAS and the ELFA method. Normal levels of FSH and LH were 1-8 IU / L and LH 2–10 IU / L, respectively. The mean age of COVID-19 survivors was 36.56 ± 5.69 while the mean marriage duration was 9.56 ± 6.17. The majority of participants had comorbid obesity class I of 6/18 (28.57%) with a mean waist circumference was 91.00 ± 11.68. Mild type COVID-19 was the most frequent 9/18 (50.0%). There were 3/18 (16.7%) pneumonia confirmed COVID-19, but only 2/3 pneumonia confirmed COVID-19 that had elevated FSH and LH levels.
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Al-Baadani, AM, Elzein, FE, Alhemyadi, SA, Khan, OA, Albenmousa, AH, & Idrees, MM 2019. Characteristics and outcome of viral pneumonia caused by influenza and Middle East respiratory syndrome-coronavirus infections: a 4-year experience from a tertiary care center. Annals of thoracic medicine, 14(3), 179. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611200/
Arbor N, Day R, Newcombe J, Talbot PJ. 2000. by human respiratory coronaviruses. J Virol [Internet]. 74 (19), pp.8913–21. Available from:https://pubmed.ncbi.nlm.nih.gov/10982334/
Arcavi, L., & Benowitz, NL 2004. Cigarette smoking and infection. Archives of internal medicine, 164(20), pp. 2206-2216. Available from: https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/217624
Abobaker A, Raba AA. Does COVID-19 affect male fertility? World J Urol. 2021 Mar; 39 (3), pp. 975–6. Available from:https://pubmed.ncbi.nlm.nih.gov/32318855/
Baig AM, Khaleeq A, Ali U, Syeda H. 2020. Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms. ACS Chemical Neuroscience; 11(7), pp. 2995–8. Available from:https://pubs.acs.org/doi/full/10.1021/acschemneuro.0c00122
Barbonetti, A., Calogero, A. E., Balercia, G., Garolla, A., Krausz, C., et al. 2018. The use of follicle stimulating hormone (FSH) for the treatment of the infertile man: position statement from the Italian Society of Andrology and Sexual Medicine (SIAMS). Journal of endocrinological investigation, 41(9), pp. 1107-1122.
Bintoro SUY, Dwijayanti NMI, Pramudya D et al. 2021. Hematologic and coagulopathy parameter as a survival predictor among moderate to severe COVID-19 patients in non-ICU ward: a single-center study at the main referral hospital in Surabaya, East Java, Indonesia [version 1; peer review: pending peer review] F1000Research, 10:791. https://doi.org/10.12688/f1000research.53803.1
Çayan S, Uğuz M, Saylam B, Akbay E. 2020. Effect of serum total testosterone and its relationship with other laboratory parameters on the prognosis of coronavirus disease 2019 (COVID-19) in SARS-CoV-2 infected male patients: a cohort study, 23 (5), 1493–503. Available from:https://www.tandfonline.com/doi/abs/10.1080/13685538.2020.1807930
Channappanavar R, Perlman S. 2017. Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology. Semin Immunopathol, 39 (5), 529–39. Available from:https://pubmed.ncbi.nlm.nih.gov/28466096/
Chaoqun Ma, Jiawei Gu, Pan Hou, Liang Zhang, Yuan Bai, et al. 2020.incident, clinical characteristics and prognostic factors of patients with COVID-19: a systematic review and meta-analysis. medRxiv. Available from: https://www.medrxiv.org/content/10.1101/2020.03.17.20037572v1
Clinckemalie L, Spans L, Dubois V, Laurent M, Helsen C, Joniau S, et al. 2013. Androgen Regulation of the TMPRSS2 Gene and the Effect of an SNP in an Androgen Response Element. Molecular Endocrinology [Internet]. , 27 (12), 2028–40. Available from:https://academic.oup.com/mend/article/27/12/2028/2615050
Darmadi D, Pakpahan C, Ruslie RH, Rezano A. 2021. Inflammatory laboratory findings associated with severe illness among hospitalized individuals with COVID-19 in Medan, Indonesia: a cross-sectional study. F1000Res.10, pp. 1246. Available from:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792878/
Guan, WJ, Ni, ZY, Hu, Y., Liang, WH, Ou, CQ, et al. 2020. Clinical characteristics of coronavirus disease 2019 in China. New England journal of medicine, 382(18), 1708-1720. Available from:https://www.nejm.org/doi/full/10.1056/neJMoa2002032
Gerui Li, Ze Chen, Zhan Lv, Hang Li, Danqi Chang, Xi Jinping Lu. 2021, "Diabetes Mellitus and COVID-19: Associations and Possible Mechanisms, International Journal of Endocrinology, pp. 10. Available from https://doi.org/10.1155/2021/7394378
Hamming I, Timens W, Bulthuis MLC, Lely AT, Navis GJ, van Goor H. 2004. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. The Journal of Pathology [Internet], 203(2), 631–7. Available from:https://onlinelibrary.wiley.com/doi/full/10.1002/path.1570
Heller CG, Clermont Y. 1963. Spermatogenesis in man: An estimate of its duration. Science 140(3563):pp. 184–6. Available from:https://www.science.org/doi/abs/10.1126/science.140.3563.184
Hoffmann, M., Kleine-Weber, H., Schroeder, S., Krüger, N., Herrler et al. 2020. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. cell, 181(2), pp. 271-280. Available fromhttps://www.sciencedirect.com/science/article/pii/S0092867420302294
Ibrahim, F., Natasha, A., Saharman, YR, & Sudarmono, P. (2020). Preliminary report of COVID-19 testing: experience of the clinical microbiology laboratory University of Indonesia, Jakarta, Indonesia. New microbes and new infections, 37, 100733. Available fromhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408335/.
Jackson, CB, Farzan, M., Chen, B., & Choe, H. 2022. Mechanisms of SARS-CoV-2 entry into cells. Nature Reviews Molecular Cell Biology, 23 (1), pp. 3-20. Available from:https://www.nature.com/articles/s41580-021-00418-x
Karyono, DR, & Wicaksana, AL (2020). Current prevalence, characteristics, and comorbidities of patients with COVID-19 in Indonesia. Journal of Community Empowerment for Health, 3(2), 77. https://doi.org/10.22146/JCOEMPH.57325
Khalangot, M., Sheichenko, N., Gurianov, V., Vlasenko, V., Kurinna, Y. 2021. Relationship between hyperglycemia, waist circumference, and the course of COVID-19: Mortality risk assessment. Experimental Biology and Medicine, Available from:http://iem.net.ua/upload/catalog/176/Relationship_between_hyperglycemia_COVID-19.pdf
Kandasamy M, Radhakrishnan RK, Poornimai Abirami GP, Roshan SA, Yesudhas A, Balamuthu K, et al. 2019a. Possible Existence of the Hypothalamic-Pituitary-Hippocampal (HPH) Axis: A Reciprocal Relationship Between Hippocampal Specific Neuroestradiol Synthesis and Neuroblastosis in Aging Brains with Special Reference to Menopause and Neurocognitive Disorders. Neurochemical Research, 44(8), 1781–95. Available from:https://link.springer.com/article/10.1007/s11064-019-02833-1
Kandasamy M, Radhakrishnan RK, Poornimai Abirami GP, Roshan SA, Yesudhas A, Balamuthu K, et al. 2019b. Possible Existence of the Hypothalamic-Pituitary-Hippocampal (HPH) Axis: A Reciprocal Relationship Between Hippocampal Specific Neuroestradiol Synthesis and Neuroblastosis in Aging Brains with Special Reference to Menopause and Neurocognitive Disorders. Neurochemical Research, 44(8), 1781–95. Available from:https://link.springer.com/article/10.1007/s11064-019-02833-1
Levison ME. 1994. Pneumonia, Including Necrotizing Pulmonary Infections (Lung Abscess). In: Braunwald E, Fauci AS, Hauser SL, Longo DL, Kasper DL, Jameson JL, editors. Harrison's principles of internal medicine. 2001. 15th ed. New York: McGraw -Hill; pp. 1475–84
Li, H., Liu, SM, Yu, XH, Tang, SL, & Tang, CK 2020. Coronavirus disease 2019 (COVID-19): current status and future perspectives. International Journal of Antimicrobial Agents, 55 (5), pp. 105951.http://www.thelancet.com/article/S0140673620305663/fulltext
Li MY, Li L, Zhang Y, Wang XS. 2020. Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues. Infect Dis Poverty, 28; 9(1), pp. 45. Available from:https://pubmed.ncbi.nlm.nih.gov/32345362/
Liu, F., Li, L., Xu, M., Wu, J., Luo, D., Zhu, Y., et al. 2020. Prognostic value of interleukin-6, C-reactive protein, and procalcitonin in patients with COVID-19. Journal of clinical virology, 127. Available from:https://www.sciencedirect.com/science/article/pii/S1386653220301128? Via%3Dihub
Lucas JM, Heinlein C, Kim T, Hernandez SA, Malik MS, True LD, et al. 2014. The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis. Cancer Discovery, 4 (11): pp. 1310–25. Available from:https://aacrjournals.org/cancerdiscovery/article/4/11/1310/4015/The-Androgen-Regulated-Protease-TMPRSS2-Activates
Lundholm, MD, Poku, C., Emanuele, N., Emanuele, MA, & Lopez, N. 2020. SARS-CoV-2 (COVID-19) and the endocrine system. Journal of the Endocrine Society, 4(11), pp. bvaa144. Available from:https://doi:10.1210/jendso/bvaa144
Maghsoumi-Norouzabad, L., Javid, AZ, Aiiashi, S., Hosseini, SA, Dadfar, M., Bazyar, H., & Dastoorpur, M. 2020. The impact of obesity on various semen parameters and sex hormones in Iranian men with infertility: a cross-sectional study. Research and Reports in Urology, 12, 357. Available from:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481269/
Ma L, Xie W, Li D, Shi L, Ye G, Mao Y, et al. 2020a. Evaluation of sex-related hormones and semen characteristics in reproductive-aged male COVID-19 patients. Journal of Medical Virology, 93(1): pp.456–62. Available from:https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.26259
Ma L, Xie W, Li D, Shi L, Ye G, Mao Y, et al. 2020b. Evaluation of sex-related hormones and semen characteristics in reproductive-aged male COVID-19 patients. Journal of Medical Virology, 93(1): pp.456–62. Available from:https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.26259
Michalakis, K., & Ilias, I. 2020. SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects. Diabetes & metabolic syndrome, 14(4), pp. 469–471. Available from:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189186/
Oyola MG, Handa RJ. 2017. Hypothalamic – pituitary – adrenal and hypothalamic – pituitary – gonadal axes: sex differences in regulation of stress responsiveness, 20 (5), pp. 476–94. Available from:https://www.tandfonline.com/doi/abs/10.1080/10253890.2017.1369523
Okçelik, S. (2021). COVID‐19 pneumonia causes lower testosterone levels. Andrologia, 53(1), pp. e13909.
Pascual-Goñi E, Fortea J, Martínez-Domeño A, Rabella N, Tecame M, Gómez-Oliva C, et al. 2020. COVID-19-associated ophthalmoparesis and hypothalamic involvement. Neurology -Neuroimmunology Neuroinflammation, 7 (5). Available from:https://nn.neurology.org/content/7/5/e823
Guidelines for preparedness for the novel coronavirus (2019-nCOV). Directorate General of Infection Prevention and Control.10. Surveillance case definition for definitions for human infection with novel coronavirus (nCoV). Interim guidance v2, World Health Organization, 2020 January 15. Available from: https://infectionemerging.kemkes.go.id
Peng, M., He, J., Xue, Y., Yang, X., Liu, S., & Gong, Z. 2021. Role of Hypertension on the Severity of COVID-19: A Review. Journal of cardiovascular pharmacology, 78(5), e648.Available from:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562915/
Petrakis, V., Panagopoulos, P., Papazoglou, D., & Papanas, N. 2022. Diabetes mellitus and hypertension as major risk factors of mortality from Covid-19 pneumonia. Experimental and Clinical Endocrinology & Diabetes, 130(03), pp. 205-206. Available from:https://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-1325-0381
Ramasamy S, Subbian S. 2021. Critical Determinants of Cytokine Storm and Type I Interferon Response in COVID-19 Pathogenesis. Clin Microbiol Rev., 34 (3). Available from:https://pubmed.ncbi.nlm.nih.gov/33980688
Ranabir S, Reetu K. Stress and hormones. 2011. Indian Journal of Endocrinology and Metabolism, 15 (1): 18. Available from:https://journals.lww.com/indjem/Fulltext/2011/15010/Stress_and_hormones.4.aspx
Sardu, C., Gambardella, J., Morelli, MB, Wang, X., Marfella, R., & Santulli, G. (2020). Hypertension, thrombosis, kidney failure, and diabetes: is COVID-19 an endothelial disease? A comprehensive evaluation of clinical and basic evidence. Journal of clinical medicine, 9 (5), 1417. Available from:https://www.mdpi.com/2077-0383/9/5/1417
Selvaraj K, Ravichandran S, Krishnan S, Radhakrishnan RK, Manickam N, Kandasamy M. 2021. Testicular Atrophy and Hypothalamic Pathology in COVID-19: Possibility of the Incidence of Male Infertility and HPG Axis Abnormalities. Reprod Sci, 28 (10), pp. 2735–42. Available from:https://pubmed.ncbi.nlm.nih.gov/33415647/
Siddique F, Abbas RZ, Mansoor MK, Alghamdi ES, Saeed M, Ayaz MM, et al. 2021. An Insight Into COVID-19: A 21st Century Disaster and Its Relation to Immunocompetence and Food Antioxidants. Full. 7, Frontiers in Veterinary Science. Available from:https://www.frontiersin.org/articles/10.3389/fvets.2020.586637/full
Stanley KE, Thomas E, Leaver M, Wells D. 2020. Coronavirus disease-19 and fertility: viral host entry protein expression in male and female reproductive tissues. Fertility and Sterility 114 (1), pp. 33–43. Available from:http://www.fertstert.org/article/S0015028220304350/fulltext
Temiz, MZ, Dincer, MM, Hacibey, I., Yazar, RO, Celik, C, et al. 2021 'Investigation of SARS-CoV-2 in semen samples and the effects of COVID-19 on male sexual health by using semen analysis and serum male hormone profile: A cross-sectional, pilot study', Andrologia, 53(2), pp . 1–9. Available from:https://onlinelibrary.wiley.com/doi/pdf/10.1111/and.13912.
Tribowo JA, Tanojo TD, Supardi S, Pakpahan C, Siswidiyanto EB, Rezano A, et al. 2021. The Impact of the Coronavirus Disease-19 Pandemic on Sexual Behavior of Marriage People in Indonesia. Open Access Macedonian Journal of Medical, 9(A), pp. 440–5. Available from:https://oamjms.eu/index.php/mjms/article/view/6277
Von Eckardstein, S., Simoni, M., Bergmann, M., Weinbauer, G. F., Gassner, P., Schepers, A. G., & Nieschlag, E.1999. Serum inhibin B in combination with serum follicle-stimulating hormone (FSH) is a more sensitive marker than serum FSH alone for impaired spermatogenesis in men, but cannot predict the presence of sperm in testicular tissue samples. The Journal of Clinical Endocrinology & Metabolism, 84(7), pp. 2496-2501.
Wang Z, Xu X. 2020. scRNA-seq Profiling of Human Testes Reveals the Presence of the ACE2 Receptor, A Target for SARS-CoV-2 Infection in Spermatogonia, Leydig and Sertoli Cells, 9 (4), pp. 920. Available from:https://www.mdpi.com/2073-4409/9/4/920/htm
WHO Coronavirus (COVID-19) Dashboard | WHO Coronavirus (COVID-19) Dashboard With Vaccination Data [Internet]. [cited 2022 Apr 3]. Available from:https://covid19.who.int/
Wahyuhadi J, Triyono EA, Waloejo CS et al. Therapy for patients with asymptomatic and mild cases of COVID-19 in Indonesia [version 1; peer review: 1 approved, 1 approved with reservations] F1000Research 2021, 10:898https://doi.org/10.12688/f1000research.52833.1
Wulandari, L., Hamidah, B., Pakpahan, C. et al. 2021. Initial study on TMPRSS2 p.Val160Met genetic variant in COVID-19 patients. Hum Genomics 15, 29. Available
Xiong, TY, Huang, FY, Liu, Q., Peng, Y., Xu, YN, Wei, JF, ... & Chen, M. (2020). Hypertension is a risk factor for adverse outcomes in patients with coronavirus disease 2019: a cohort study. Annals of medicine, 52(7), 361-366.from:https://humgenomics.biomedcentral.com/articles/10.1186/s40246-021-00330-7
Yu J. 2014. Endocrine disorders and the neurologic manifestations. Annals of Pediatric Endocrinology & Metabolism, 19(4), pp. 184–90. Available from:http://e-apem.org/journal/view.php?doi=10.6065/apem.2014.19.4.184
Zanza C, Romenskaya T, Manetti AC, Franceschi F, la Russa R, Bertozzi G, et al. 2022. Cytokine Storm in COVID-19: Immunopathogenesis and Therapy. Medicine, 58(2), pp. 144. Available from:https://www.mdpi.com/1648-9144/58/2/144/htm
Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. 2020. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. the Lancet, 395 (10229), pp. 1054–62. Available from:http://www.thelancet.com/article/S0140673620305663/fulltext
Zumla A, Hui DS, Azhar EI, Memish ZA, Maeurer M. Reducing mortality from 2019-nCoV: host-directed therapies should be an option. Lancet, 395 (10224): pp. e35 – e36. Available from:https://pubmed.ncbi.nlm.nih.gov/32035018/
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