Efficacy of adjuvant therapy gingko biloba extract on vitiligo treated by topical desoximetasone to melanin index and vasi score
Keywords:
ginkgo biloba, vitiligo, herbal medicine, adjuvant, skin healthAbstract
Ginkgo biloba (GB) has anxiolytic properties, which can help to prevent the spread of vitiligo lesions. The purpose of this study was to examine the efficacy of adding orally and placebo GB extract as adjuvant therapy in treating depigmented lesions in vitiligo patients. This research is an experimental study with samples of vitiligo patients at the Dermatology and Venereology Polyclinic, RSUD Dr. Moewardi, Surakarta, Central Java, Indonesia. This study involved 23 patients aged 18-60 years. The sample met the inclusion criteria: routine control patients with stable non-segmental vitiligo with less than 20% lesions and not receiving therapy for the past four weeks. Research subjects were divided into two groups using a capsule containing 60 mg of GB extract and a placebo. The data were processed by statistical analysis using the SPSS and the Mann-Whitney test with a significance P-value <0.05. The results showed that the administration of GB was able to significantly reduce the melanin index in vitiligo patients at week 12 (p = 0.003 < 0.05).
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Adnani, H., Subiyanto, A., Hanim, D., & Sulaeman, E. S. (2018). Health promotion in clean and healthy behavior programs in traditional markets. International Research Journal of Management, IT and Social Sciences, 5(4), 46-52. https://doi.org/10.21744/irjmis.v5n4.251
Bae JM, Ju HJ (2020) Surgical interventions for vitiligo. J Korean Med Assoc 63: 748–755.
Ban C, Park JB, Cho S, et al. (2020) Characterization of Ginkgo biloba leaf flavonoids as neuroexocytosis regulators. Molecules 25.
Bergqvist C, Ezzedine K (2020) Vitiligo: A Review. Dermatology 236: 571–592.
Chiang PH, Lin YJ, Chiu YC, et al. (2021) Feasibility of oral tranexamic acid for vitiligo patients with melasma. Dermatol Ther 34.
de Menezes AF, Oliveira de Carvalho F, Barreto RSS, et al. (2017) Pharmacologic Treatment of Vitiligo in Children and Adolescents: A Systematic Review. Pediatr Dermatol 34: 13–24.
Farag AG, Marae AH, Habib MSE, et al. (2017) IL-8 mRNA and serum levels in vitiligo patients: A case control study. J Clin Diagnostic Res 11: WC01–WC04.
Frisoli ML, Essien K, Harris JE (2020) Vitiligo: Mechanisms of Pathogenesis and Treatment. Annu Rev Immunol 38: 621–648.
Hamdan M, Noorhamdani AS, Rahayu M, et al. (2019) Influence of ginkgo biloba (Egb) extracts in apoptosis index and number of neurons at rattus novergicus with lead (pb) exposure. Res J Pharm Technol 12: 5883–5887.
Jeong KH, Kim SK, Seo JK, et al. (2021) Association of GZMB polymorphisms and susceptibility to non-segmental vitiligo in a Korean population. Sci Rep 11.
Kadry M, Tawfik A, Abdallah N, et al. (2018) Platelet-rich plasma versus combined fractional carbon dioxide laser with platelet-rich plasma in the treatment of vitiligo: A comparative study. Clin Cosmet Investig Dermatol 11: 551–559.
Kamde SS, Sawarkar G (2020) The prime role of preventive approach of ayurveda in autoimmune disorder with special reference to vitiligo. Indian J Forensic Med Toxicol 14: 6691–6697.
Kuroda Y, Yang L, Lai S, et al. (2021) A lower irradiation dose of 308 nm monochromatic excimer light might be sufficient for vitiligo treatment: A novel insight gained from in vitro and in vivo analyses. Int J Mol Sci 22.
Lu L, Wang S, Fu L, et al. (2016) Bilobalide protection of normal human melanocytes from hydrogen peroxide-induced oxidative damage via promotion of antioxidase expression and inhibition of endoplasmic reticulum stress. Clin Exp Dermatol 41: 64–73.
Mansourpour H, Ziari K, Motamedi SK, et al. (2019) Therapeutic effects of iNOS inhibition against vitiligo in an animal model. Eur J Transl Myol 29: 251–260.
Mou K, Pan W, Han D, et al. (2019) Glycyrrhizin protects human melanocytes from H2O2‑induced oxidative damage via the Nrf2‑dependent induction of HO‑1. Int J Mol Med 44: 253–261.
Muhammed RT, Kumar R, Rani S, et al. (2018) Combination of follicular and epidermal cell suspension as a novel surgical approach in difficult-to-treat vitiligo a randomized clinical trial. JAMA Dermatology 154: 301–308.
Ou K, Wen C, Lan C, et al. (2021) The Optimal Application of Medium Potency Topical Corticosteroids in Preventing Laser-Induced Inflammatory Responses — An Animal Study. Life.
Park JS (2021) Analysis of Antioxidant Efficacy of Ginkgo Biloba Leaves and Acer Palmatum Leaves. Turkish J Comput Math Educ 12: 698–703.
Parsad D, Pandhi R, Juneja A (2003) Effectiveness of oral Ginkgo biloba in treating limited, slowly spreading vitiligo. Clin Exp Dermatol 28: 285–287.
Paudel S, Parajuli N, Dahal SC, et al. (2021) Improper Use of Topical Corticosteroids in Tinea Infections in a Tertiary Care Hospital. J Nepal Health Res Counc 19: 71–75.
Raju S, Sivanesan SK, Gudemalla K, et al. (2019) Effect of Ginkgo biloba extract on Hematological and Biochemical Alterations in Fluoride Toxicity in Wistar rats. Res J Pharm Technol 12: 3915–3918.
Sava A, Piciu A, Pasca S, et al. (2020) Topical Corticosteroids a Viable Solution for Oral Graft versus Host Disease ? A Systematic Insight on Randomized Clinical Trials. Medicina (B Aires) 1–9.
Seok SH, Kim DH (2020) Pathogenesis of vitiligo. J Korean Med Assoc 63: 725–730.
Smith MK, Mohammad TF, Hamzavi IH (2017) Assessment of Dietary Supplementation in the Treatment of Vitiligo. Open Dermatol J 11: 12–21.
Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Get vaccinated when it is your turn and follow the local guidelines. International Journal of Health Sciences, 5(3), x-xv. https://doi.org/10.53730/ijhs.v5n3.2938
Szczurko O, Shear N, Taddio A, et al. (2011) Ginkgo biloba for the treatment of vitilgo vulgaris: An open label pilot clinical trial. BMC Complement Altern Med 11.
Tulic MK, Cavazza E, Cheli Y, et al. (2019) Innate lymphocyte-induced CXCR3B-mediated melanocyte apoptosis is a potential initiator of T-cell autoreactivity in vitiligo. Nat Commun 10: 1–13.
Vinodini R, Hazel AMA, Sundaram MM, et al. (2019) Clinical Evaluation of Parangipattai chooranam (internal) and Annabedhi chenduram (external) for Venpulli (Vitiligo) in children. Res J Pharm Technol 12: 5932–5936.
Vivas, F. E. V., Cuello, R. L. C., Macías, D. M., & Rosado, G. P. (2017). Elaboration of essential oil from the oregano for medicinal use sheet. International Journal of Physical Sciences and Engineering, 1(1), 81–87. https://doi.org/10.21744/ijpse.v1i1.22
Wang JY, Chen H, Wang YY, et al. (2017) Network pharmacological mechanisms of Vernonia anthelmintica (L.) in the treatment of vitiligo: Isorhamnetin induction of melanogenesis via up-regulation of melanin-biosynthetic genes. BMC Syst Biol 11: 1–12.
Wang K, Ni J, Zhu X, et al. (2021) Ginkgo biloba extract protects human neuroblastoma SH‑SY5Y cells against oxidative glutamate toxicity by activating redoxosome‑p66Shc . Exp Ther Med 22.
Wang Y, Li S, Li C (2019) Perspectives of new advances in the pathogenesis of vitiligo: From oxidative stress to autoimmunity. Med Sci Monit 25: 1017–1023.
Xin XJ, Zou J, Zou T, et al. (2018) A Newly Authenticated Compound from Traditional Chinese Medicine Decoction Induces Melanogenesis in B16-F10 Cells by Increasing Tyrosinase Activity. Evidence-based Complement Altern Med 2018.
Zhang S, Yi X, Su X, et al. (2019) Ginkgo biloba extract protects human melanocytes from H2O2-induced oxidative stress by activating Nrf2. J Cell Mol Med 23: 5193–5199.
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