The effect of psycho-curative towards anxiety, cortisol, and PIBF level of pregnant woman during COVID-19 pandemic

Soetrisno Soetrisno; Hafi Nurinasari; Erindra Budi Cahyanto; Rufidah Maulina; Siti Nurhidayati; Haris Nur Ashfi Arifa; Cinantya Dwi Jayanti; Arif Nur Muhammad Ansori; Nanda Yuli Rahmawati; Revi Gama Hatta Novika

doi:10.53730/ijhs.v6nS2.5017

Authors

Soetrisno Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia
Hafi Nurinasari Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia
Erindra Budi Cahyanto Vocational School, Universitas Sebelas Maret, Surakarta, Indonesia
Rufidah Maulina Midwifery Study Program, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia
Siti Nurhidayati Midwifery Study Program, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia
Haris Nur Ashfi Arifa Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia
Cinantya Dwi Jayanti Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia
Arif Nur Muhammad Ansori Doctoral Program of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia and Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India
Nanda Yuli Rahmawati Doctoral Program of Medical Sciences, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
Revi Gama Hatta Novika
revi.gama@staff.uns.ac.id
Midwifery Study Program, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia

Keywords:

anxiety, cortisol, PIBF, pregnant women, psychocurative

Abstract

Managing stress plays a vital role in building a healthier support system for pregnancy and increased fetal growth. However, many pregnant women undergo stress during the COVID-19 pandemic. Cortisol is associated with early miscarriage derived by the adrenal glands responding to stress. In addition, anxiety has side effects on women’s quality of life. PIBF mediates the immunomodulatory effects of progesterone during pregnancy. This study aimed to measure the changes in anxiety, cortisol, and PIBF, levels in the pregnant woman due to increased stress during the COVID-19 pandemic. This study was conducted in Community Health Center Surakarta, Indonesia. This study used twenty pregnant women and classified into two groups. The control group was given regular prenatal assessment, while the treatment group was given a psychocurrative intervention, including cognitive, social, spiritual, and physical support. This intervention was performed once a week in a class and twice at their homes. Blood was collected from the pregnant woman to measure PIBF and cortisol levels before and after the intervention. In addition, anxiety was measured using the DASS-21 scale. The paired t-test analysis was conducted to compare between the control and experimental groups at a significant level of 5%.

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References

Abedzadeh-Kalahroudi, M., Sehat, M., Vahedpour, Z., Talebian, P., Haghighi, A. (2021). Clinical and obstetric characteristics of pregnant women with Covid-19: A case series study on 26 patients. Taiwan J. Obstet. Gynecol. 60 (3): 458-462. https://doi.org/10.1016/j.tjog.2021.03.012.

Ali, N.S., Azam, I.S., Ali, B.S., Tabbusum, G., Moin, S.S. (2012). Frequency and associated factors for anxiety and depression in pregnant women: a hospital-based cross-sectional study. Sci. World J. 2012: 653098. https://doi.org/10.1100/2012/653098.

Awick, E.A., Ehlers, D.K., Aguiñaga, S., Daugherty, A.M., Kramer, A.F., McAuley, E. (2017). Effects of a randomized exercise trial on physical activity, psychological distress and quality of life in older adults. Gen. Hosp. Psychiatry. 49: 44-50. https://doi.org/10.1016/j.genhosppsych.2017.06.005.

Bergman, K., Sarkar, P., O'Connor, T.G., Modi, N., Glover, V. (2007). Maternal stress during pregnancy predicts cognitive ability and fearfulness in infancy. J Am Acad Child Adolesc Psychiatry. 46 (11): 1454-1463. https://doi.org/10.1097/chi.0b013e31814a62f6.

Connor, J., Madhavan, S., Mokashi, M., Amanuel, H., Johnson, N.R., Pace, L.E., Bartz, D. (2020). Health risks and outcomes that disproportionately affect women during the Covid-19 pandemic: A review. Soc. Sci. Med. 266: 113364. https://doi.org/10.1016/j.socscimed.2020.113364.

Cook, N., Ayers, S., Horsch, A. (2018). Maternal posttraumatic stress disorder during the perinatal period and child outcomes: A systematic review. J Affect Disord. 225: 18-31. https://doi.org/10.1016/j.jad.2017.07.045.

Davis, E.P., Sandman, C.A. (2010). The timing of prenatal exposure to maternal cortisol and psychosocial stress is associated with human infant cognitive development. Child Dev. 81 (1): 131-148. https://doi.org/10.1111/j.1467-8624.2009.01385.x.

Durankuş, F., Aksu, E. (2022). Effects of the COVID-19 pandemic on anxiety and depressive symptoms in pregnant women: A preliminary study. J. Matern. Fetal Neonatal. Med. 35 (2): 205-211. https://doi.org/10.1080/14767058.2020.1763946.

Fan, S., Guan, J., Cao, L., Wang, M., Zhao, H., Chen, L., Yan, L. (2021). Psychological effects caused by COVID-19 pandemic on pregnant women: A systematic review with meta-analysis. Asian J. Psychiatr. 56: 102533. https://doi.org/10.1016/j.ajp.2020.102533.

Hamzehgardeshi, Z., Omidvar, S., Amoli, A.A., Firouzbakht, M. (2021). Pregnancy-related anxiety and its associated factors during COVID-19 pandemic in Iranian pregnant women: A web-based cross sectional study. BMC Pregnancy Childbirth. 21 (1): 208. https://doi.org/10.1186/s12884-021-03694-9.

Henry, J.D., Crawford, J.R. (2005). The short-form version of the Depression Anxiety Stress Scales (DASS-21): construct validity and normative data in a large non-clinical sample. Br. J. Clin. Psychol. 44 (Pt 2): 227-39. https://doi.org/10.1348/014466505X29657.

Ito, T., Goto, K., Takanari, J., Miura, T., Wakame, K., Nishioka, H., Tanaka, A., Nishihira, J. (2014). Effects of enzyme-treated asparagus extract on heat shock protein 70, stress indices, and sleep in healthy adult men. J. Nutr. Sci. Vitaminol. 60 (4): 283-290. https://doi.org/10.3177/jnsv.60.283.

Kane, H.S., Dunkel Schetter, C., Glynn, L.M., Hobel, C.J., Sandman, C.A. (2014). Pregnancy anxiety and prenatal cortisol trajectories. Biol. Psychol. 100: 13-9. https://doi.org/10.1016/j.biopsycho.2014.04.003.

Khoury, J.E., Atkinson, L., Bennett, T., Jack, S.M., Gonzalez, A. (2021). COVID-19 and mental health during pregnancy: The importance of cognitive appraisal and social support. J. Affect Disord. 282: 1161-1169. https://doi.org/10.1016/j.jad.2021.01.027

Koenig, H.G. (2012). Religion, spirituality, and health: The research and clinical implications. ISRN Psychiatry. 2012: 278730. https://doi.org/10.5402/2012/278730.

Kuepfer, L. (2010). Towards whole-body systems physiology. Mol. Syst. Biol. 6: 409. https://doi.org/10.1038/msb.2010.70.

Lebel, C., MacKinnon, A., Bagshawe, M., Tomfohr-Madsen, L., Giesbrecht, G. (2020). Elevated depression and anxiety symptoms among pregnant individuals during the COVID-19 pandemic. J. Affect Disord. 277: 5-13. https://doi.org/10.1016/j.jad.2020.07.126.

Lim, M.K., Ku, C.W., Tan, T.C., Lee, Y.H.J., Allen, J.C., Tan, N.S. (2020). Characterisation of serum progesterone and progesterone-induced blocking factor (PIBF) levels across trimesters in healthy pregnant women. Sci. Rep. 10 (1): 3840. https://doi.org/10.1038/s41598-020-59452-y.

López-Morales, H., Del Valle, M.V., Canet-Juric, L., Andrés, M.L., Galli, J.I., Poó, F., Urquijo, S. (2021). Mental health of pregnant women during the COVID-19 pandemic: A longitudinal study. Psychiatry Res. 295: 113567. https://doi.org/10.1016/j.psychres.2020.113567.

Mah, B.L., Pringle, K.G., Weatherall, L., Keogh, L., Schumacher, T., Eades, S., Brown, A., Lumbers, E.R., Roberts, C.T., Diehm, C., Smith, R., Rae, K.M. (2019). Pregnancy stress, healthy pregnancy and birth outcomes - the need for early preventative approaches in pregnant Australian Indigenous women: A prospective longitudinal cohort study. J Dev Orig Health Dis. 10 (1): 31-38. https://doi.org/10.1017/S204017441800079X.

Malhotra, S., Sahoo, S. (2017). Rebuilding the brain with psychotherapy. Indian J. Psychiatry. 59(4): 411-419. https://doi.org/10.4103/0019-5545.217299.

Nepomnaschy, P.A., Welch, K.B., McConnell, D.S., Low, B.S., Strassmann, B.I., England, B.G. (2006). Cortisol levels and very early pregnancy loss in humans. Proc. Natl. Acad. Sci. U.S.A. 103 (10): 3938-3942. https://doi.org/10.1073/pnas.0511183103.

Novika, R.G.H., Santoso, B., Widjiati, W. (2019). The effect of psychological stress on MPF intrafollicular. Int. J. Appl. Pharm. 11 (5): 127-130. https://doi.org/10.22159/ijap.2019.v11s5.T0102.

Poole, K.L., Van Lieshout, R.J., McHolm, A.E., Cunningham, C.E., Schmidt, L.A. (2018). Trajectories of social anxiety in children: Influence of child cortisol reactivity and parental social anxiety. J. Abnorm. Child Psychol. 46(6): 1309-1319. https://doi.org/10.1007/s10802-017-0385-3.

Prady, S.L., Pickett, K.E., Croudace, T., Fairley, L., Bloor, K., Gilbody, S., Kiernan, K.E., Wright, J. (2013). Psychological distress during pregnancy in a multi-ethnic community: Findings from the born in Bradford cohort study. PLoS One. 8 (4): e60693. https://doi.org/10.1371/journal.pone.0060693.

Rauf, N., Zulfiqar, S., Mumtaz, S., Maryam, H., Shoukat, R., Malik, A., Rowther, A.A., Rahman, A., Surkan, P.J., Atif, N. (2021). The impact of the COVID-19 pandemic on pregnant women with perinatal anxiety symptoms in Pakistan: A qualitative study. Int. J. Environ. Res. Public Health. 18 (16): 8237. https://doi.org/10.3390/ijerph18168237.

Salari, N., Hosseinian-Far, A., Jalali, R., Vaisi-Raygani, A., Rasoulpoor, S., Mohammadi, M., Rasoulpoor, S., Khaledi-Paveh, B. (2020). Prevalence of stress, anxiety, depression among the general population during the COVID-19 pandemic: A systematic review and meta-analysis. Global Health. 16 (1): 57. https://doi.org/10.1186/s12992-020-00589-w.

Scheinost, D., Sinha, R., Cross, S.N., Kwon, S.H., Sze, G., Constable, R.T., Ment, L.R. (2017). Does prenatal stress alter the developing connectome? Pediatr. Res. 81 (1-2): 214-226. https://doi.org/10.1038/pr.2016.197.

Shah, N.M., Imami, N., Johnson, M.R. (2018). Progesterone modulation of pregnancy-related immune responses. Front. Immunol. 9: 1293. https://doi.org/10.3389/fimmu.2018.01293.

Soetrisno, Cahyanto, E.B., Mulyani, S., Nugraheni, A., Nurinasari, H., Tjiang, R.E. (2020). The cortisol level, depression anxiety stress score, and quality of life in patient with advance stage cervical cancer after two years of psychorative intervention. Bali Med. J. 9 (1): 6-12. https://doi.org/10.15562/bmj.v9i1.1636.

Soetrisno, S., Mulyani, S., Nurinasari, H., Budi, E. (2019). The influence of psychocurative on cortisol level, anxiety, and quality of life in advanced stage cervical cancer patients. Folia Medica Indones. 55 (3): 202. https://doi.org/10.20473/fmi.v55i3.15502.

Szekeres-Bartho, J. (2018). The role of progesterone in feto-maternal immunological cross talk. Med. Princ. Pract. 27 (4): 301-307. https://doi.org/10.1159/000491576.

Szekeres-Bartho, J., Polgar, B. (2010). PIBF: The double-edged sword. Pregnancy and tumor. Am. J. Reprod. Immunol. 64 (2): 77-86. https://doi.org/10.1111/j.1600-0897.2010.00833.x.

Szekeres-Bartho, J., Šućurović, S., Mulac-Jeričević, B. (2018). The role of extracellular vesicles and PIBF in embryo-maternal immune-interactions. Front. Immunol. 9: 2890. https://doi.org/10.3389/fimmu.2018.02890.

Turner, L., Galante, J., Vainre, M., Stochl, J., Dufour, G., Jones, P.B. (2020). Immune dysregulation among students exposed to exam stress and its mitigation by mindfulness training: Findings from an exploratory randomised trial. Sci. Rep. 10 (1): 5812. https://doi.org/10.1038/s41598-020-62274-7.

van den Heuvel, M.I., Donkers, F.C., Winkler, I., Otte, R.A., Van den Bergh, B.R. (2015). Maternal mindfulness and anxiety during pregnancy affect infants' neural responses to sounds. Soc. Cogn. Affect Neurosci. 10 (3): 453-460. https://doi.org/10.1093/scan/nsu075.

Viandika, N., Septiasari, R.M. (2021). Anxiety in pregnant women during pandemic covid-19. J Keperawatan Jiwa Persat. Perawat Nas. Indones. 2021; 9 (1): 135-142. https://doi.org/10.26714/jkj.9.1.2021.135-142.

Villar, J., Ariff, S., Gunier, R.B., Thiruvengadam, R., Rauch, S., Kholin, A., Roggero, P., Prefumo, F., do Vale, M.S., Cardona-Perez, J.A., Maiz, N., Cetin, I., Savasi, V., Deruelle, P., Easter, S.R., Sichitiu, J., Soto Conti, C.P., Ernawati, E., Mhatre, M., Teji, J.S., Liu, B., Capelli, C., Oberto, M., Salazar, L., Gravett, M.G., Cavoretto, P.I., Nachinab, V.B., Galadanci, H., Oros, D., Ayede, A.I., Sentilhes, L., Bako, B., Savorani, M., Cena, H., García-May, P.K., Etuk, S., Casale, R., Abd-Elsalam, S., Ikenoue, S., Aminu, M.B., Vecciarelli, C., Duro, E.A., Usman, M.A., John-Akinola, Y., Nieto, R., Ferrazi, E., Bhutta, Z.A., Langer, A., Kennedy, S.H., Papageorghiou, A.T. (2021). Maternal and neonatal morbidity and mortality among pregnant women with and without covid-19 infection: The intercovid multinational cohort study. JAMA Pediatr. 175 (8): 817-826. https://doi.org/10.1001/jamapediatrics.2021.1050.