Development & characterization of clotrimazole multiple emulsion
Keywords:
clotrimazole, poly-dispersed, surfactantAbstract
The present study is the development and characterization of clotrimazole multiple emulsion. The purpose of this research is to enhance the release of drug as well as the bioavailability of particular drug. After formulation of multiple emulsion of drug clotrimazole some characterization like pre-formulations and evaluation study was performed. It shows excellent results for all parameters. On the basis of in vitro drug release the zero-order release study shows that the ME-2 formulation is more stable and effective for antifungal activity.
Downloads
References
Akhtar N, Mahmud A; et al., “Formulation and characterization of a multiple emulsion containing 1% l-Ascorbic acid”, Bull. Chem. Soc. Ethiop. 2010, 24(1), 1-10. DOI: https://doi.org/10.4314/bcse.v24i1.52955
Bhatia N., Pandit S., Agrawal S. and Gupta D. A review on multiple emulsions. International Journal of Pharmaceutical Erudition. 2013; 3(2): 22-30.
Collings, A, J, British Patent no.1235667, 19971.
Deshmukh R.L. Multiple emulsion: Strategic and technology. Asian Journal of Pharmaceutical Education and Technology, 2014; 2(2): 1-19.
Ghosh S., “Formulation and Characterizations of Multiple Emulsions with Various Additives”, international journal of research in pharmaceutical and biomedical sciences. Apr – Jun 2011, Vol. 2 (2).
Gohla, S, H and Nielsen, J.SOFW J, 1995, 121, 707.
Hanpramukkun N, Kongmuang S, et al., “The stability of Clindamycin phosphate in w/o/w multiple emulsions,” Int J Pharm Sci Tech, 2009, 3(2): 0975-0525.
Kumar R., Kumar M.S. and Mahadevan N. Multiple emulsions: A review. International Journal of Recent Advances in Pharmaceutical Research. 2012; 2(1): 9-19.
Madaan V., Chanana A., Kataria M.K. and Bilandi A. Emulsion technology and recent trends in emulsion applications. International Research Journal of Pharmacy. 2014; 5(7): 533-542. DOI: https://doi.org/10.7897/2230-8407.0507108
Matsumoto, S, Kita Y. and Yonezawa, D, J Colloid Interface sci, 1976, 57 353. DOI: https://doi.org/10.1016/0021-9797(76)90210-1
Nimbekar T.P., Wanjari B.E., Sanghi D.K. and Gaikwad N.J. 2012. Formulation and evaluation of sustained release multiple emulsion of hydroxyprogestrone. International Journal of Pharmacy and Pharmaceutical Sciences. 4(1): 76- 80.
Prajapati S.B., Bhatt H., Koli A., Dharamsi A. and Shah S.A. An overview of preparation, evaluation and applications of multiple emulsions. International Journal for Pharmaceutical Research Scholars. 2013; 2(1): 142-150.
Vyas S.P. and Khar R.K. Multiple emulsions: Novel carrier systems. CBS Publishers and Distributors. First Edition, 2004; 303-328.
Yoshioka, T, Ikeuchi,K, K, Hashida, M, Muranishi, s, and sezaki, H,chem. Pharma, Bull, 1982,20.1408. DOI: https://doi.org/10.1248/cpb.30.1408
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.
