Mimicking human antidepressant activity in Swiss Albino Mice using Madhuca Longifolia
Keywords:
Antidepressant activity, Madhuca longifolia, Forced swim test, Tail suspension test, Reserpine induced HypothermiaAbstract
The present study was evaluated to screen the antidepressant potential of Madhuca longifolia in different animal models like forced swim test (FST), tail suspension test(TST), reserpine induced hypothermia (RIH). Adult swiss albino mice weighing 25- 30 gm.Standard drug used in above study was Fluoxetine(10mg/kg,p.o). The antidepressant activity of Madhuca longifolia was compared to the standard drug. The model shows closely mimics symptoms & signs of human depression. The high dose of Madhuca longifolia showed extremely high significant values over standard drugs with a decrease in immobility and ptosis. The results obtained in the present study suggest that Madhuca longifolia proves to be a potential therapeutic drug for treating depression along with anti-inflammatory, anti-psoriatic and antioxidant activity.
Downloads
References
Abbey LR. Characterization of animals of behavioural models using juvenile mices for screening paediatric antidepressants efficacy. United States: University of Nebraska - thesis publicaton; 2008. 185: 396-404.
Borsini F, Meli A. Is the forced swimming test a suitable model for revealing antidepressant activity Psychopharmacology.1988, 94, 147-60. DOI: https://doi.org/10.1007/BF00176837
LererB.,Macciardi, F. Pharmacogenetics of antidepressant and mood stabilizing drugs: a review of candidate-gene studies and future research directions. The International Journal of Neuropsychopharmacology. 2002, 5, 255-275. DOI: https://doi.org/10.1017/S1461145702002936
Narongchai P, Omboon L and Leena S. Rapid reversed‐phase high performance liquid chromatography for vitexin analysis and fingerprint of Passiflora foetida. Current science. 2007, 93,378‐382.
OECD 2001-gudeline on Acute Oral Toxicity (AOT) Environmental health safety monograph series on testing and adjustment No.425.
Patil A., et al. “Complete Genome Sequence of Lactobacillusplantarum Strain JDARSH, Isolated from Sheep Milk”. MicrobiologyResourceAnnouncements9.2 (2020). DOI: https://doi.org/10.1128/MRA.01199-19
Patil A., et al. “Probiotic potential of Lactobacillus plantarumwith the cell adhesion properties”. Journal of Global PharmaTechnology10.12 (2018): 1-6.
Patil A., et al. “Shelf-life stability of encapsulated lactic acidbacteria isolated from Sheep milk thrived in different milk asnaturalmedia”.SmallRuminantResearch170(2019):19-25. DOI: https://doi.org/10.1016/j.smallrumres.2018.09.014
Patil AR and Disouza J. “Isolation and characterisation of Lactobacillusspeciesfromsheepmilk”.InternationalJournalofInnovativeScienceEngineeringandTechnology1.1(2020):9-17.
Patil AR, Patil P. “The Insight of Body’s Immune System,Inflammation and Damages in Wound Healing- The review”.InternationalJournalforResearchinAppliedScienceandEngineeringTechnology9.8 (2021):2777-2780. DOI: https://doi.org/10.22214/ijraset.2021.37868
Patil AR. “Lactobacillus rhamnosusARJD as a Functional Foodwith Potential Antioxidant and Antibacterial Abilities”. ActaScientificPharmaceuticalSciences3(2019):63-70. DOI: https://doi.org/10.31080/ASPS.2019.03.0341
Patil AR. “The role of the food and fertilizers in antimicrobialresistance in human and its preventive measures”. International Journal of Innovative Science, Engineering and Technology1.1 (2020): 31-37.
Patil AR. “Use of Probiotics as a Functional Food against Cancer”. Acta Scientific Pharmaceutical Sciences 3.8 (2019): 103-105. DOI: https://doi.org/10.31080/ASPS.2019.03.0347
Patil AR., et al. “Lactobacillus Model Moiety a New Era DosageForm as Nutraceuticals and Therapeutic Mediator”. In Biotechnology and Bio forensics Springer, Singapore (2015): 11-21. DOI: https://doi.org/10.1007/978-981-287-050-6_2
Patil AR., et al. “Nanotechnology based upgradation in tuberculosisdiagnosis andtreatment” (2020):395-414.
PatilA, DisouzaJ.“Genomic-BasedRestrictionEnzymeSe-lection for Specific Detection of Lactobacillus rhamnosusandLactobacillusplantarumstrainby16SrDNAPCR-RFLP”.Inter-national Journal of Innovative Science, Engineering and Technology1.1 (2020): 91-99.
PatilA.,etal.“Bananafiberscamouflagingasagutwormina 6-month-old infant”. Iberoamerican Journal of Medicine 3(2020): 245-247. DOI: https://doi.org/10.53986/ibjm.2020.0043
PatilA.,etal.“EvaluationofLactobacillusplantarumgrowthinmilkofIndianbuffalobreedsbasedonitsphysico-chemicalcontent”.BuffaloBulletin38.2(2019):345-352.
PatilAR.“Theoriginofnovelcoronavirus:COVID-19”.International Journal of Innovative Science, Engineering and Technology1.1 (2020): 18-23.
Porsolt R, Anton G, Jafre M. Behavioural despair in mices: A new model sensitive to antidepressant treatments. Eur. J. Pharmacol. 1978, 47, 379-391. DOI: https://doi.org/10.1016/0014-2999(78)90118-8
Reynolds E H. Brain and mind: a challenge for WHO. Lancet 2003, 361, 1924-1925. DOI: https://doi.org/10.1016/S0140-6736(03)13600-8
Shoba.S, Patil.P.A, Vivek.V. Hepatoprotective activity of Madhuca longifolia. aqueous extract against paracetamol, isoniazid and alcohol induced hepatotoxicity in male wistarmices, Int J of Phytopharmcol. 2008, 23, 291-296
Soulimani R, Younos C, Jarmouni S, Bousta D, Misslin R and Mortier F. Behavioral effects of Passifloraincarnata L. and its indole alkaloid and flavonoid derivatives and maltol in the mouse. JEthnopharmacol. 1997; 57: 11‐20 DOI: https://doi.org/10.1016/S0378-8741(97)00042-1
Thase ME, Howland RH. Biological processes in depression: an update and integmiceion. In: Beckham EE, Leber WR, Handbook of Depression, 2nd ed., New York, Guilford, 1995, 3,213–279.
VangeoisM., PasseraG., ZuccaroF. and CosteninJ., Individual differences in response to imipramine in the tail mouse us pension test, Psychopharmacology. 1997, 134, 387-391. DOI: https://doi.org/10.1007/s002130050475
Yu ZF Kong LD and Chen Y. Antidepressant activity of aqueous extracts of Curcuma longa in mice: Ethnopharmocol. 2002, 83, 161- 65. DOI: https://doi.org/10.1016/S0378-8741(02)00211-8
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.
