Assessment of wound healing using Nano-crystalline silver membrane placed following periodontal flap surgery
Keywords:
Antibacterial, Nano-crystalline silver particles, gingival surfaceAbstract
Background: Nanomaterials are widely explored in Periodontics, as well as controlled drug release in forms of hollow spheres, core-shell, nanotubes and other active components. The present study was conducted to assess wound healing using Nano-crystalline silver membrane placed following periodontal flap surgery. Materials & Methods: 60 patients diagnosed with chronic periodontitis of both genders were divided into 2 groups of 30 each. Group I received a nano-crystalline silver dressing and group II received non-eugenol dressing. Flap surgery in each patient was carried out. Parameters such as wound healing index, microbiological analysis and vascular endothelial growth factor (VEGF) were recorded at the 7th and 14th day postoperatively. Results: Patients in group I received a nano-crystalline silver dressing and in group II, non-eugenol dressing. Group I had 14 males and 16 females and group II had 12 males and 18 females. The mean healing index on 7th day was 3.75 and 2.28 in group I and II and 4.12 and 3.14 in in group I and II on 14th day respectively. The difference was significant (P< 0.05). CFU/ml (X106) pre- operatively and post- operatively was 3.4 and 1.6 and 1.5 and 1.8 in group I and II respectively.
Downloads
References
Rai M, Yadav A, Gade A. Silver nanoparticles as a new generation of antimicrobials. Biotechnol Adv. 2009;27:76–83.
Rigo C, Ferroni L, Tocco I, Roman M, Munivrana I, Gardin C, et al. Active silver nanoparticles for wound healing. Int J Mol Sci. 2013;14:4817–40.
Lin YH, Hsu WS, Chung WY, Ko TH, Lin JH. Silver-based wound dressings reduce bacterial burden and promote wound healing. Int Wound J. 2016;13:505–11.
Sirisha P, Gayathri GV, Dhoom SM, Amulya KS. Antimicrobial effect of silver nanoparticles synthesised with Ocimum sanctum leaf extract on periodontal pathogens. J Oral Health Dent Sci. 2017;1:1–7.
Habiboallah G, Mahdi Z, Majid Z, Nasroallah S, Taghavi AM, Forouzanfar A, et al. Enhancement of gingival wound healing by local application of silver nanoparticles periodontal dressing following surgery: A histological assessment in animal model. Mod Res Inflamm. 2014;3:128–38.
Nissen NN, Polverini PJ, Koch AE, Volin MV, Gamelli RL, DiPietro LA. Vascular endothelial growth factor mediates angiogenic activity during the proliferative phase of wound healing. Am J Pathol. 1998;152:1445–52.
Shah JM, Omar E, Pai DR, Sood S. Cellular events and biomarkers of wound healing. Indian J Plast Surg. 2012;45:220–8.
Yamakawa S, Hayashida K. Advances in surgical applications of growth factors for wound healing. Burns Trauma. 2019;7:10.
Eming SA, Krieg T, Davidson JM. Inflammation in wound repair: Molecular and cellular mechanisms. J Invest Dermatol. 2007;127:514–25.
Aggarwal K, Gupta S, Sood S, Bhardwaj SB, Prashar S, Jain A. Effect of nano-crystalline silver membrane on early wound healing after periodontal surgery: A comparative randomized study. Journal of Indian Society of Periodontology. 2021 Nov;25(6):504.
Kadam P, Mahale S, Sonar P, Chaudhari D, Shimpi S, Kathurwar A. Efficacy of silver nanoparticles in chronic periodontitis patients: A clinico-microbiological study. Iberoamerican J Med. 2020;2:142–7.
Masurkar SA, Chaudhari PR, Shidore VB, Kamble SP. Effect of biologically synthesised silver nanoparticles on Staphylococcus aureus biofilm quenching and prevention of biofilm formation. IET Nanobiotechnol.2012;6(3):110-4.
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.








