Formulation, development & evaluation of antihypertensive microsphere ionotropic gelatin method
Keywords:
captopril, FTIR, microspheres, microencapsulation, sodium alginateAbstract
Captopril is an ACE inhibitor that is used for the treatment of high blood pressure. The reason of this examine became to encapsulate the drug in unique polymer having mucoadhesive belongings and hence combining the benefits of microparticulates with mucoadhesive drug transport device. The microcapsules with a coat which include alginate and a mucoadhesive polymer including sodium carboxymethylcellulose (SCMC), methylcellulose, Carbopol 934P and hydroxyl propylmethylceullulose (HPMC) E15V have been organized through ionotropic gelation method, in which gelation became finished with oppositely charged counter ions to shape microparticles. The organized microcapsules have been subjected for diverse evaluations. The ensuing microparticles had been discrete, large, round and loose–flowing. Captopril release from those microcapsules became gradual and prolonged over longer duration of time. Drug launch for a few formula became diffusion controlled and others exhibited anomalous behavior. The organized microcapsules exhibited correct mucoadhesive belongings in the in vitro wash–off test. Among all formulations, batch containing sodium alginate and carbopol 934 confirmed better encapsulation efficiencies, correct float belongings and most prolongation of drug launch and correct mucoadhesion residences drug release and excellent mucoadhesion residences.
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References
Brahmankar DM and Jaiswal SB. Biopharmaceutics and Pharmacokinetics–A Treatise 1st ed. Vallabh Prakashan, New Delhi, 2003.
Deshpande AA, Shah NH, Rhodes CT and Malick W. Development of novel controlled release system for Gastric retention. Pharma. Res. 1997; 14: 815–819.
Davis SS. Formulation Strategies for absorption Windows. Drug Discovery Today. 2005; 10 (4), 249–257.
Chen J, Park H and Park K. Superporous Hydrogels as a Platform for Oral Controlled Drug Delivery. In: Wise DL, Ed. Handbook of Pharmaceutical Controlled Release Technology. Marcel Dekker, INC, New York, 2005, pp.211–224.
Soppimath KS, Kulkarni AR, Rudzinski WE and Aminabhavi TM. Microspheres as floating drug delivery Systems to increase Gastric Retention of drugs. Drug Metabolism Reviews. 2001; 33 (2): 149–160
Ponchel G and Irache JM. Specific and non-specific Bioadhesive particulate system for oral delivery to Gastrointestinal tract. Advanced Drug Delivery Reviews. 1998; 34: 191–219.
Mathiowitz E, Chickering D, Jacob J, and Santos C. Bioadhesive Drug Delivery Systems. In: Mathiowitz E, ed. Encyclopedia of Controlled Drug Delivery. John Wiley and Sons, INC, New York, 1999. Pp. 9-45.
Bakan JA. Microencapsulation. In: Lachman L, Lieberman HA, Kanig JL. Eds. The Theory and Practice Of Industrial Pharmacy. 3rd ed. Varghese Publishing House, Bombay, 1991. Pp. 412–429.
Chowdary KPR and Rao YS. Mucoadhesive Microcapsules of glipizide: Characterization, in vitro and In vivo evaluation. Ind. J Pharm. Sci. 2003; 65 (3): 279–284.
Holford NHG and Benet LZ. Pharmacokinetics and Pharmacodynamics: Dose Selection and the Time Course of Drug Action. In: Katzung BG, Ed. Basic and Clinical Pharmacology, 7th ed. McGraw Hill, New York, 2003. pp. 34–49.
Martin A. Physical Pharmacy. 4th ed. B.I. Waverly Pvt. Ltd, New Delhi, 1999
Alvarez-Lorenzo C, Concheiro A, Dubovik AS, Grinberg Burova TV and Ginberg VY. Temperature–sensitive chitosan poly (N–isopropylacrylamide) interpenetrated network with enhanced loading capacity and controlled release properties. J. Control. Rel. 2005; 102, 629–641
Picas K, Tchao R and Ofner III CM. Gelatin–methotrexate conjugate microspheres as a potential drug delivery system. J Pharm Sci. 2006; 95 (9): 1896–1908.
Abu IK, Gracia CL and Robert LD. Preparation and evaluation of zidovudine loaded sustained release microspheres. J. Pharm. Sci. 1996; 85 (6): 575–576.
Chowdary KPR and Rao YS. Preparation and evaluation of mucoadhesive microcapsules of indomethacin. Ind. J. Pharm. Sci. 2003; 65 (1): 49–52.
Patil SB and Murthy RSR. Preparation and in vitro encapsulation of mucoadhesive chitosan microspheres of amlodipine besylate for nasal administration. Ind. J. Pharm. Sci. 2006; 68 (1): 64–67
Hajare AA, More HN and D’Souza JI. Design and evaluation of sustained release tablets of diltiazem hydrochloride. Indian Drugs. 2004; 41 (3): 175–176
Xion XY, Tam KC and Gan LH. Release kinetics of hydrophobic and hydrophilic model drugs from pluronic F127/Poly (lactic acid) nanoparitcles. J. Control. Rel. 2005; 103: 73–82.
Cleland JL and Jones AJS. Stable formulations of recombinant human growth hormone and interferon for microencapsulation in biodegradable microspheres. Pharm. Res. 1996; 13: 1464–1475.
Torres D, Boado L, Blanko D and Vila–Jato JL. Comparison between aqueous and non–aqueous solvent evaporation methods for microencapsulation of drug resin complexes. Int. J. Pharm. 1998; 173: 171–182.
Agarwal V and Mishra B. Design, development and biopharmaceutical properties of buccoadhesive compacts of pentazocine. Drug Develop. Ind. Pharm. 1999; 25: 701–709.
Reppas C and Nicolaides E. Analysis of drug dissolution data. In: Dressman JB, Lennernas H, Eds. Oral Drug Absorption Prediction and Assessment. Marcel Dekker, INC, New York, 2000. pp. 229-254
Vueba ML, Batista de Carvalho LAE, Veiga F, Sousa JJ and Pina ME. Influence of cellulose ether polymers on ketoprofen release from hydrophilic matrix tablets. Eur. J. Pharm. Biopharm. 2004; 58: 51-59.
Li L, Nelson ED, Seburg RA and Reed RA. Nucleophilic group transfer reactivity for fibric acid derived drug molecules. J. Pharm. Sci. 2006; 95 (9): 1954–1966.
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