Evaluation of 8-Hydroxy deoxyguanosine levels, as a marker of oxidative stress in chronic gingivitis and chronic periodontitis individuals during the course of phase 1 periodontal therapy in comparison with periodontally healthy individuals

Stuti Chandrajit Jha; Amit Chaudhari; Vidya Dodwad; Dhananjay Dhiren Sheth; Nishita Bhosale; Avneet Kaur

doi:10.53730/ijhs.v6nS1.8569

Authors

Stuti Chandrajit Jha
stutijha166@gmail.com
Post Graduate, Department of Periodontology, Bharati Vidyapeeth Dental College and Hospital, Pune, Maharashtra, India
Amit Chaudhari Associate Professor, Department of Periodontology, Bharati Vidyapeeth Dental College and Hospital, Pune, Maharashtra, India
Vidya Dodwad Head of Department, Department of Periodontology, Bharati Vidyapeeth Dental College and Hospital, Pune, Maharashtra, India
Dhananjay Dhiren Sheth Post Graduate, Department of Prosthodontics and Crown and Bridge, Bharati Vidyapeeth Dental College and Hospital, Pune, Maharashtra, India
Nishita Bhosale MDS Periodontology, Junior Lecturer, Bharati Vidyapeeth Dental College and Hospital, Pune, Maharashtra, India
Avneet Kaur Post Graduate, Department of Periodontology, Bharati Vidyapeeth Dental College and Hospital, Pune, Maharashtra, India

Keywords:

chronic periodontitis, 8-OHdG, oxidative stress

Abstract

Aim: The aim was to evaluate the levels of 8-Hydroxy deoxyguanosine levels, as a marker of oxidative stress in Chronic Gingivitis and Chronic Periodontitis individuals during the course of Phase 1 periodontal therapy in comparison with Periodontally healthy Individuals. Materials and Method: All the individuals were divided into 3 groups each including 16 subjects. Group 1 included healthy subjects and group 3 and 4 included subjects with chronic gingivitis and chronic periodontitis respectively. Saliva samples were collected and the 8-OHdG levels were assessed. Results: The levels reduced to 1.59±0.50 in chronic periodontitis group one month after scaling and root planing. A statistically non-significant value of 0.09 was recorded. The levels in chronic gingivitis group were 1.20±0.89. Conclusion: From the above study it can be concluded that 8-OHdG is an important biomarker of oxidative stress and is increased in patients with chronic gingivitis and chronic periodontitis.

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