Comparison of serum interleukin 34 levels in chronic periodontitis patients before and after periodontal flap surgery
Keywords:
Interleukin 34, proinflammatory cytokines, chronic periodontitis, therapeutic agentAbstract
Background: Interleukin-34 (IL-34) is a recently identified alternative ligand for colony-stimulating factor-1 receptor which plays an important role in osteoclastogenesis. The aim of this study was to evaluate the IL-34 levels in serum in subjects with chronic periodontitis and to evaluate the effect of surgical periodontal therapy on the serum IL-34 levels. Materials and Methods: Thirty individuals (age range: above 20 years) with chronic periodontitis were selected and divided into groups: Group I (chronic periodontitis patients before periodontal flap surgery), while Group II patients after periodontal flap surgery Ramfjord periodontal diseases index and sulcus bleeding index (Muhlemman and Sons 1971) were examined. Serum samples were collected to estimate the levels of IL-34 using enzyme-linked immunosorbent assay kit. Results: The mean IL-34 concentration in serum was highest for Group I and it significantly decreased after periodontal flap surgery. The difference between them was statistically significant (P < 0.05). Conclusion: IL-34 can be considered as an “inflammatory marker” of periodontal disease and can be explored in the future as a potential therapeutic target in the treatment of periodontal disease.
Downloads
References
Trowbridge HO, Emling RC. Inflammation: a review of the process. Illinois: Quintessence Publishing Co, Inc.; 1997.
Birkedal-Hansen H. Role of cytokines and inflammatory mediators in tissue destruction. J Periodontal Res 1993;
Nakaya H, Oates TW, Hoang AM, Kamoi K, Cochran DL. Effects of interleukin-1 beta on matrix metalloproteinase-3 levels in human periodontal ligament cells. J Periodontol 1997;
Nishikawa M, Yamaguchi Y, Yoshitake K, Saeki Y. Effects of TNFalpha and prostaglandin E2 on the expression of MMPs in human periodontal ligament fibroblasts. J Periodontal Res 2002;37:167-76.
Wang Y, Colonna M. Interkeukin-34, a cytokine crucial for the differentiation and maintenance of tissue resident macrophages and langerhans cells. Eur J Immunol 2014;
Eda H, Zhang J, Keith RH, Michener M, Beidler DR, Monahan JB, et al. Macrophage-colony stimulating factor and interleukin-34 induce chemokines in human whole blood. Cytokine 2010
Lin H, Lee E, Hestir K, Leo C, Huang M, Bosch E, et al. Discovery of a cytokine and its receptor by functional screening of the extracellular proteome. Science 2008;320:807-11.
Liu H, Leo C, Chen X, Wong BR, Williams LT, Lin H, et al. The mechanism of shared but distinct CSF-1R signaling by the non-homologous cytokines IL-34 and CSF-1. BiochemBiophys Acta 2012;1824:938-45.
Wang Y, Colonna M. Interkeukin-34, a cytokine crucial for the differentiation and maintenance of tissue resident macrophages and langerhans cells. Eur J Immunol 2014;44:1575-81
Franzè E, Monteleone I, Cupi ML, et al. Interleukin-34 sustains inflammatory pathways in the gut. Clin Sci. 2015;129:271–280. 52. Zwicker S, Martinez GL, Bosma M, et al. Interleukin 34
Ma N, Qu L, Xu LY, Yu YQ, Qiu LH. Expression of IL-34 in chronic periapical lesions and its clinical significance. Shanghai Kou Qiang Yi Xue. 2016;25:53–57.
San Segundo D, Ruiz P, Irure J, et al. Serum levels of interleukin34 during acute rejection in liver transplantation. Transplant Proc. 2016;48:2977–29
Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2022). Post-pandemic health and its sustainability: Educational situation. International Journal of Health Sciences, 6(1), i-v. https://doi.org/10.53730/ijhs.v6n1.5949
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.
