Synthesis, structural investigation and molecular docking studies of pyridinyl tetrahydroisoquinoline, morpholine and piperidine containing schiff's bases

Anupama Roy; Sushil Kumar; Arun Kumar Sharma

doi:10.53730/ijhs.v6nS5.8909

Authors

Anupama Roy
anupamaroy0208@gmail.com
Faculty of Pharmacy IFTM University, Moradabad Uttar Pradesh-244102, India
Sushil Kumar Faculty of Pharmacy IFTM University, Moradabad Uttar Pradesh-244102, India
Arun Kumar Sharma Faculty of Pharmacy IFTM University, Moradabad Uttar Pradesh-244102, India

Keywords:

Schiff's bases, pyridinyl tetrahydroisoquinoline, morpholine, piperidine, aromatic amines, aminobenzaldehyde

Abstract

The present work was conducted to synthesize some Schiff's bases derived from pyridinyl tetrahydroisoquinoline, morpholine and piperidine moieties by the condensation reaction of aminobenzaldehyde with various aromatic amines in good to excellent yield. The structures of synthesized compounds were confirmed by ¹H NMR, 13C NMR and mass spectra (ESI-MS) data. These compounds also evaluated for their in silico anti-microbial properties by molecular docking studies. Docking studies were carried out by using Argus Lab 4.0.1 software.

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