Association of lipid abnormalities with thyroid dysunction in patients of subclinical hypothyroidism

Ramakant Rawat; Manoj Kumar; Sushil Kumar; Granth Kumar

doi:10.53730/ijhs.v6nS1.5613

Authors

Ramakant Rawat Associate Professor, Department of Medicine, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India
Manoj Kumar Professor, Department of Medicine, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India
Sushil Kumar Assistant Professor, Department of Medicine, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India
Granth Kumar Associate Professor, Department of Medicine, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India

Keywords:

Antithyroid peroxidase antibodies, Thyroid stimulating hormone, Free thyroxine, Atherosclerosis, Euthyroid

Abstract

Background: Dyslipidemia is thought to associated with the risk of cardiovascular disease development. Overt hypothyroidism is associated with lipid abnormalities. However, the relationship between subclinical hypothyroidism (SCH) and pattern of lipid abnormalities is not well eastablished. The aim of this study was to find the lipid abnormalities in patients of subclinical hypothyroidism (SCH) and determine relationship between lipid level and TSH. Methods: Serum lipid levels of 92 patients with subclinical hypothyroidism (SCH) and 110 age and sex matched healthy controls were evaluated in this cross sectional case control study. Results: In this study total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) were significantly higher (p value<0.05) in patients with subclinical hypothyroidism (SCH) as compared to control group. Triglycerides (TG) and very low density lipoprotein cholesterol (VLDL-C) were also increased in these patients as compared to control but the difference was not statistically significant. High density lipoprotein cholesterol (HDL-C) was found to be marginally lower in these patients than control. Conclusions: Total cholesterol (TC) and low density lipoprotein (LDL-C) are higher in patients with subclinical hypothyroidism (SCH) as compared to healthy controls.

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