Effect of methanolic extract of sphaeranthus amaranthoides (MESA) on nicotine-induced Serum testosterone levels in adult Wistar albino rats
Keywords:
methanolic extract, sphaeranthus amaranthoides (MESA), nicotine-induced, serum testosteroneAbstract
Background: Infertility is one of the most common health issues. Infertility in men occurs when sperms cannot fertilize eggs. Infertility can be caused by a variety of factors, medical conditions, and medications. Testicular insufficiency results when a normal individual is exposed to some toxic substances and lifestyle disorders. Smoking cigarette is one such condition that affects male reproductive system. Nicotine is the main metabolite of cigarette smoke. Testicular damages are always related with hormonal changes. Objectives: The aim of this study is to evaluate the effects of Methanolic extract of sphaeranthus amaranthoides with regard to Changes in serum testosterone levels caused as a result of nicotine -induced testicular damage. Methods: Four equal groups( 24nos) of male wistar albino rats were randomly assigned to control, nicotine and methanol extract of sphaeranthus amaranthoides with doses1(250 mg/kg BW) and 2 (500 mg/kg BW), respectively. The animals were treated for forty-eight days. The blood samples were collected at the interval of 20, 40, and 48 days, to evaluate the serum testosterone levels. Results: Nicotine reduced Serum testosterone level (p < 0.001).When treated along with Methanolic extract of sphaeranthus amaranthoides treatment significantly increased blood testosterone level (p<0.001).
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Testosterone and testicular changes in F1 offspring of Wistar rats maternally exposed to nicotine during gestation Ibukun P Oyeyipo,1 Damilare H Adeyemi,1 and Temilade R Abe1JBRA Assist Reprod. 2018 Jul-Sep; 22(3): 162–166. doi: 10.5935/1518-0557.20180031}
WHO - World Health Organization . The World Health Report 1999 - Making a difference. Geneva: World Health Organization; 1999
Haustein KO. Cigarette smoking, nicotine and pregnancy. Int J Clin PharmacolTher. 1999;37:417–427.
Oyeyipo IP, Raji Y, Bolarinwa AF. Nicotine alters male reproductive hormones in male albino rats: The role of cessation. J Hum Reprod Sci. 2013;6:40–44.doi: 10.4103/0974-1208.112380.
Pasqualotto FF, Sobreiro BP, Hallak J, Pasqualotto EB, Lucon AM. Cigarette smoking is related to a decrease in semen volume in a population of fertile men. BJU Int. 2006;97:324–326. doi: 10.1111/j.1464-410X.2005.05906.x
Rustemeier K, Stabbert R, Haussmann HJ. Evaluation of the potential effects of ingredients added to cigarettes. Part 2: Chemical composition of mainstream smoke. Food Chem Toxicol 2002;40:93–104.
Guey-Shyang Hwang et al., Effects of hypoxia on testosterone release in rat leydig cells Am J Physiol Endocrinol Metab 297: doi:10.1152/ajpendo.00010.2009.
Mohammad Reza Salahshoorcrocin and nicotine Crocin Improves Damage Induced by Nicotine on A Number of Reproductive Parameters in Male Mice International Journal of Fertility and Sterility 10(1):71-8 DOI:10.22074/ijfs.2016.4771
Risperidone induced reproductive toxicity in male rats targeting leydig cells and hypothalamic–pituitary–gonadal axis by inducing oxidative stress GözdeGörmüşAndrologia. 2020;00, doi.org/10.1111/and.138
Ibukun P Oyeyipo Nicotine alters male reproductive hormones in male albino rats: The role of cessation (,Journal of Human Reproductive Sciences / Volume 6 / Issue 1 / Jan - Mar 2013 DOI: 10.4103/0974-1208.112380
Murugesamudaliyar, Gunapadamporutpanbunool, Siddha materia medicapg .no: 229
FahimehMohammadghasemiet al ., The amelioration of nicotine-induced reproductive impairment in male mouse by Sambucus ebulus L. fruit extractAnat Cell Biol 2021; 54(2): 232-
Ibukun Peter Oyeyipo et al, 240Effects of Nicotine on Sperm Characteristics and Fertility Profile in Adult Male Rats: A Possible Role of CessationJReprodInfertil. 2011 Jul-Sep; 12(3): 201–207.
Fatima Ayaz et al., Study to Investigate the Hormone Analysis in Male Albino Rats under the Pharmacological Kinetics of Thimerosal Scholars Bulletin DOI: 10.36348/sb.2021.v07i06.001
https://www.nih.gov/news-events/nih-research-matters/understanding-how-testosterone-affects-men
Gonadal steroids and body composition, strength, and sexual function in men. N Engl J Med. 2013 Sep 12;369(11):1011-22. doi: 10.1056/NEJMoa1206168. PMID: 24024838.
Rachid Mosbah Nicotine-induced reproductive toxicity, oxidative damage, histological changes and haematotoxicity in male rats: The protective effects of green tea Experimental and Toxicologic Pathologydoi.org/10.1016/j.etp.2015.01.001
George FW, Wilson JD. Hormonal control of sexual development. VitamHorm. 1986;43:145–196. doi: 10.1016/S0083-6729(08)60420-3.; Mooradian AD, Morley JE, Korenman SG. Biological actions of androgens. Endo Rev. 1987;8:1–28. doi: 10.1210/edrv-8-1-1.
Karanth, S., Yu, W.H., Walczewska, A., Mastronardi, C.A. and McCann, S.M. (2001) Ascorbic Acid Stimulates Gonadotropin Release by Autocrine Action by Means of NO. Proceedings of the National Academy of Sciences of the United States of America, 98, 11783-11
S. Kanimozhi et al., Histological Changes In Testis Of Adult Wistar Albino Rats - Nicotine-Induced Testicular Damages And The Protective Effects Of Methonolic Extract Of Sphaeranthus Amaranthoides Journal of Pharmaceutical Research InternationalDOI: 10.9734/JPRI/2022/XXXXX
Sundaram KK, Bupesh G, Saravanan KM. Instrumentals behind embryo and cancer: a platform for prospective future in cancer research. AIMS Molecular Science, 9: 25-45, 2022. Doi: 10.3934/molsci.2022002
Suryasa, I.W., Sudipa, I.N., Puspani, I.A.M., Netra, I.M. (2019). Translation procedure of happy emotion of english into indonesian in kṛṣṇa text. Journal of Language Teaching and Research, 10(4), 738–746
Ramli, R. M., Sinrang, A. W., & Aminuddin. (2021). Levels of alpha-1 acid glycoprotein (AGP) in stunting and non stunting tolls age 36-60 months . International Journal of Health & Medical Sciences, 4(1), 145-149. https://doi.org/10.31295/ijhms.v4n1.1666
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