Diabetes a major risk factor for blinding condition of Neovascular Glaucoma
An update on this condition
Keywords:
Neovascular glaucoma, Secondary glaucoma, Rubeosis iridis, Retinal hypoxia, diabetic retinopathyAbstract
Importance: Neovascular glaucoma (NVG) is a severe form of secondary glaucoma has a varying prevalence of 0.01 to 3.9% of all glaucoma in different regions of world. Majority of them are affected with proliferative diabetic retinopathy. Although NVG overall prevalence is low but it is a dreadful condition led to blindness. If not detected earlier of the disease by latest investigating majors and treated systematically on different stages of the disease along with taking care of the alleviation of different aggravating factors for retinal hypoxia. Objectives: To summarize published evidence on etiopathogenesis, clinical feature, stages of NVG and to provide treatment recommendation on different stages of the NVG for ophthalmologists based on published evidence. Evidence Review: A literature search of PubMed was conducted from January 1, 1974 to June 30, 2022. Publications describing prevalence, etiopathogenesis, clinical staging, investigation and treatment modality were included in the study. Findings: NVG is characterized by development of new vessels on iris and fibrovascular tissue proliferation in the anterior chamber angle with increase in IOP, principally driven by Retinal ischemia and among the commonest causes are proliferative diabetic neuropathy (PDR), central retinal venous occlusion, and ocular ischemic syndrome (OIS).
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An L, Wang RK. In vivo volumetric imaging of vascular perfusion within human retina and choroids with optical micro angiography. Opt Express2008;16:11438 52.
Arcieri ES, Paula JS, Jorge R, Barella KA, Arcieri RS, Secches DJ, et al. Efficacy and safety of intravitreal bevacizumab in eyes with neovascular glaucoma undergoing Ahmed glaucoma valve implantation: 2‐year follow‐up. Acta Ophthalmol 2015;93:e1 6.
Barac IR, Pop MD, Gheorghe AI, Taban C. Neovascular secondary glaucoma, etiology and pathogenesis. Rom J Ophthalmol 2015;59:24 8.
Bloom PA, Tsai JC, Sharma K, Miller MH, Rice NS, Hitchings RA, et al. “Cyclodiode”: Trans scleral diode laser cyclophotocoagulation in the treatment of advanced refractory glaucoma. Ophthalmol 1997;104:1508 20
Brancato R, Bandello F, Lattanzio R. Iris fluorescein angiography in clinical practice. Surv Ophthalmol 1997;42:41 70.
Brown GC, Magargal LE, Schachat A, Shah H. Neovascular glaucoma:Etiologic considerations.Ophthalmology 1984;91:315 20.
Callahan MA. Photocoagulation and rubeosis iridis. Am J Ophthalmol 1974;78:873 4.
Callahan MA. Photocoagulation and rubeosis iridis. Am J Ophthalmol 1974;78:873 4.
Casey R, Li WW. Factors controlling ocular angiogenesis (review). Am J Ophthalmol. 1997;124:521-529.
Cho N, Shaw J, Karuranga S, Huang Y, da Rocha Fernandes J, Ohlrogge A, et al. IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract 2018;138:271 81
Christakis PG, Kalenak JW, Tsai JC, Zurakowski D, Kammer JA, Harasymowycz PJ, et al. The Ahmed versus Baerveldt study: Five year treatment outcomes. Ophthalmol 2016;123:2093 102...
Coats G. Further cases of thrombosis of the central vein. J. & A. Churchill; 1906
Dubey S, Pegu J. Management of neovascular glaucoma. J Curr Glaucoma Pract 2009;3:27 34
Fiebai, B. & Onua, Alfred. (2019). Prevalence, Causes and Management of Neovascular Glaucoma: A 5-Year Review. Open Journal of Ophthalmology. 09. 1-8. 10.4236/ojoph.2019.91001.
Grant WM. Management of neovascular glaucoma. Paper presented at: Symposium on ocular therapy. 1974
GrantGrant WM. Management of neovascular glaucoma. Paper presented at: Symposium on ocular therapy. 1974.
Grisanti S,Biester S,Peters S,TatarO,ZiemssenF,Bartz SchmidtKU, et al. Intracameral bevacizumab foriris rubeosis.Am J Ophthalmol 2006;142:158 60
Grisanti S,Biester S,Peters S,TatarO,ZiemssenF,Bartz SchmidtKU, et al. Intracameral bevacizumab foriris rubeosis.Am J Ophthalmol 2006;142:158 60.
Hayreh SH. Neovascular glaucoma. Prog Retin Eye Res, 2007; 26: 470-85
Hayreh SS, Rojas P, Podhajsky P, Montague P, Woolson RF. Ocular neovascularization with retinal vascular occlusion III: Incidence of ocular neovascularization with retinal vein occlusion. Ophthalmology 1983;90:488 506.
Higashide T, Ohkubo S, Sugiyama K. Long term outcomes and prognostic factors of trabeculectomy following intraocular bevacizumab injection for neovascular glaucoma. PLoS One 2015;10: e0135766
Hirano T, Kakihara S, Toriyama Y, Nittala MG, Murata T, Sadda S. Wide field en face swept source optical coherence tomography angiography using extended field imaging in diabetic retinopathy. Br J Ophthalmol 2018;102:1199 203.
Horsley MB, Kahook MY. Anti VEGF therapy for glaucoma. Curr Opin Ophthalmol 2010;21:112 7.
Horsley MB, Kahook MY. Anti VEGF therapy for glaucoma. Curr Opin Ophthalmol 2010;21:112 7.
Hwang TS, Gao SS, Liu L, Lauer AK, Bailey ST, Flaxel CJ, et al. Automated quantification of capillary nonperfusion using optical coherence tomography angiography in diabetic retinopathy.JAMA Ophthalmol 2016;134:367 73.
Hwang TS, Hagag AM, Wang J, Zhang M, Smith A, Wilson DJ, et al.Automated quantification of nonperfusion areas in 3 vascular plexuses with optical coherence tomography angiography in eyes of patients with diabetes. JAMA Ophthalmol 2018;136:929 6.
Kang JY, Nam KY, Lee SJ, Lee SU. The effect of intravitreal bevacizumab injection before Ahmed valve implantation in patients with neovascular glaucoma.Int Ophthalmol 2014;34:793 9.
Kolomeyer AM, Seery CW, Emami Naeimi P, Zarbin MA, Fechtner RD, Bhagat N. Combined pars plana vitrectomy and pars plana Baerveldttube placementin eyes with neovascular glaucoma. Retina 2015;35:17 28.
Laa tikainen L. Preliminary report on effect of retinal panphotocoagulation on rubeosis iridis and neovascular glaucoma. Br J Ophthalmol 1977;61:278 84.
Laa tikainen L. Preliminary report on effect of retinal panphotocoagulation on rubeosis iridis and neovascular glaucoma. Br J Ophthalmol 1977;61:278 84.
Li ZQ, Zhou XX, Lin S, Li JL, Wu JG. Angiography reveals early hiding iris neovascularization after ischemic CRVO. Int J Ophthalmol 2013;6:253 254.
Luo J, Yan Z, Jia Y, Luo R. Clinical analysis of 42 cases of ocular ischemic syndrome. J Ophthalmol 2018;2018: 2606147. doi:10.1155/2018/2606147.
Marra KV, Wagley S, Omar A, Kinoshita T, Kovacs KD, Silva P, et al. Case matched comparison of vitrectomy, peripheral retinal endolaser, and endocyclophotocoagulation versus standard care in neovascular glaucoma. Retina 2015;35:1072 83.
Mocanu C, Barascu D, Marinescu F, Lacrateanu M, Iliusi F, Simionescu C. Neovascular glaucoma – retrospective study (in Romanian) Oftalmologia. 2005;49:58–65
Mocanu C, Barăscu D, Marinescu F, Lăcrăţeanu M, Iliuşi F, Simionescu C. Neovascular glaucoma retrospective study. Oftalmologia (Bucharest, Romania: 1990). 2005;49:58 65.
Murphy RP, Egbert PR. Regression of iris neovascularization following panretinal photocoagulation. Arch Ophthalmol 1979;97:700 2.
Murphy RP, Egbert PR. Regression of iris neovascularization following panretinal photocoagulation. Arch Ophthalmol 1979;97:700 2
Nakatake S, Yoshida S, Nakao S, Arita R, Yasuda M, Kita T, et al. Hyphema is a risk factor for failure of trabeculectomy in neovascular glaucoma:A retrospective analysis. BMC Ophthalmol 2014;14:55.
Narayanaswamy A, Baskaran M, Zheng Y, Lavanya R, Wu R, Wong WL, Saw SM, Cheng CY, Wong TY, Aung T. The prevalence and types of glaucoma in an urban Indian population: the Singapore Indian Eye Study. Invest Ophthalmol Vis Sci. 2013 Jul 10;54(7):4621-7.
Netland PA, Ishida K, Boyle JW. The Ahmed Glaucoma Valve in patients with and without neovascular glaucoma. J Glaucoma 2010;19:581 6.
Netland PA. The Ahmed glaucoma valve in neovascular glaucoma (An AOS Thesis). Trans Am Ophthalmol Soc 2009;107:325 42.
Nishat Sultana Khayoom, Totli Kuruba Mayuri A prospective observational study to evaluate the etiology and staging of neovascular glaucoma Indian Journal of Clinical and Experimental Ophthalmology 2020;6(1):123–128
OHRT V. The frequency ofrubeosis iridis in diabetic patients.Acta Ophthalmol 1971;49:301 7.
Olmos LC, Lee RK. Medical and surgical treatment of neovascular glaucoma. Int Ophthalmol Clin 2011;51:27 36.
Parodi MB, Bondel E, Russo D, Ravalico G. Iris indocyanine green videoangiography in diabetic iridopathy. Br J Ophthalmol 1996;80:416 419.
Pauk-Domańska, M., & Walasik-Szemplińska, D. (2014). Color Doppler imaging of the retrobulbar vessels in diabetic retinopathy. Journal of ultrasonography, 14(56), 28–35. https://doi.org/10.15557/JoU.2014.0003
Paul C, Sengupta S, Choudhury S, Banerjee S, Sleath BL. Prevalence of glaucoma in Eastern India: The Hooghly River Glaucoma Study. Indian J Ophthalmol. 2016 Aug;64(8):578-83.
Reilly LM, Ehrenfeld WK, Stoney RJ. Carotid digital subtraction angiography: the comparative roles of intra-arterial and intravenous imaging. Surgery. 1984 Nov;96(5):909-18. PMID: 6387992.
Roberts PK, Goldstein DA, Fawzi AA. Anterior segment optical coherence tomography angiography for identification of iris vasculature and staging of iris neovascularization: A pilot study. Curr Eye Res 2017;42:1136 42
Rodrigues GB,Abe RY, Zangalli C, Sodre SL, Donini FA, Costa DC, et al. Neovascular glaucoma: A review. Int J Retin Vitreous 2016;2:26.
Rodrigues GB,Abe RY, Zangalli C, Sodre SL, Donini FA, Costa DC, et al. Neovascular glaucoma:
Russell JF, Shi Y, Hinkle JW, Scott NL, Fan KC, Lyu C, et al. Longitudinal wide field swept source OCT angiography of neovascularization in proliferative diabetic retinopathy after panretinal photocoagulation. Ophthalmol Retina 2019;3:350 61
Sahyoun M,Azar G, Khoueir Z,Antoun J, Kourie H, Nehme J,et al. Long term results of Ahmed glaucoma valve in association with intravitreal bevacizumab in neovascular glaucoma. J Glaucoma 2015;24:383 8.
Saito Y, Higashide T, Takeda H, Ohkubo S, Sugiyama K. Beneficial effects of preoperative intravitreal bevacizumab on trabeculectomy outcomes in neovascular glaucoma. Acta Ophthalmol 2010;88:96 102.
Salus R. Rubeosis iridis diabetica, eine bisher unbekannte diabetische Irisveränderung. Med Klin 1928; 24:256 8.
Saraswati, P. A. I. ., Gunawan, I. M. K., & Budiyasa, D. G. A. (2021). Overview of glomerulus filtration in type 2 of diabetes mellitus at Sanjiwani Gianyar hospital year of 2018-2019. International Journal of Health & Medical Sciences, 4(1), 50-55. https://doi.org/10.31295/ijhms.v4n1.726
Sawada O, Ichiyama Y, Obata S, Ito Y, Kakinoki M, Sawada T,et al. Comparison between wide angle OCT angiography and ultra wide field fluorescein angiography for detecting non perfusion areas and retinal neovascularization in eyes with diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol 2018;256:1275 80.
Senthil S, Dada T, Das T, Kaushik S, Puthuran GV, Philip R, Rani PK, Rao H, Singla S, Vijaya L. Neovascular glaucoma - A review. Indian J Ophthalmol. 2021 Mar;69(3):525-534. doi: 10.4103/ijo.IJO_1591_20. PMID: 33595466; PMCID: PMC7942095.
SooHoo JR, Seibold LK, Kahook MY. Recent advances in the management of neovascular glaucoma. Paper presented at: Seminars in ophthalmology. 2013.
Spaide RF, Fujimoto JG, Waheed NK. Optical coherence tomography angiography. Retina 2015;35:2161 2. 43. Roberts PK, Goldstein DA, Fawzi AA
Spaide RF, Klancnik JM, Jr., Cooney MJ. Retinal vascular layers imaged by fluorescein angiography and optical coherence tomography angiography. JAMA Ophthalmol. 2015;133:45 50.
Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Health and treatment of diabetes mellitus. International Journal of Health Sciences, 5(1), i-v. https://doi.org/10.53730/ijhs.v5n1.2864
Takihara Y, Inatani M, Fukushima M, Iwao K, Iwao M, Tanihara H. Trabeculectomy with mitomycin C for neovascular glaucoma: Prognostic factors for surgical failure. Am J Ophthalmol 2009;147:912 918. e911.
Tasman W, Magargal LE, Augsburger JJ. Effects of argon laser photocoagulation on rubeosis iridis and angle neovascularization. Ophthalmol 1980;87:400 2.
Tasman W, Magargal LE, Augsburger JJ. Effects of argon laser photocoagulation on rubeosis iridis and angle neovascularization. Ophthalmol 1980;87:400 2.
Tasman W, Magargal LE, Augsburger JJ. Effects of argon laser photocoagulation on rubeosis iridis and angle neovascularization. Ophthalmol 1980;87:400 2.
Terelak Borys B, Skonieczna K, Grabska Liberek I. Ocularischemic syndrome–a systematic
Weiss D, Gold D. Neofibrovascularization of iris and anterior chamber angle: A clinical classification. Ann Ophthalmol 1978;10:488 91.
Weiss DI, Shaffer RN. Nehrenberg TR Neovascular glaucoma complicating carotid-cavernous fistula. Arch Ophthalmol. 1963;69(3):304– 307.
Yalvac I, Eksioglu U, Satana B, Duman S. Long term results of Ahmed glaucoma valve and Molteno implant in neovascular glaucoma. Eye 2007;21:65 70.
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