Raspberry ketone: an emerging molecule for treating depression and associated symptoms - molecular docking and pharmacokinetics studies

https://doi.org/10.53730/ijhs.v6n7.10811

Authors

  • Sanjeev Kumar Assistant Professor School of Medical and Allied Sciences, K. R. Mangalam University, Haryana, India-122103
  • Sunil Kumar Assistant Professor School of Medical and Allied Sciences, K. R. Mangalam University, Haryana, India-122103
  • Arun Garg Professor Dean, School of Medical and Allied Sciences, K. R. Mangalam University, Gurgaon 122103, Haryana, India +91-8373988629 ORCID ID: 0000-0003-4718-5519
  • Silky Sethy Professor School of Pharmaceutical Sciences, Om Stearling Global University, Haryana, India- 125044
  • Puja Gulati Professor School of pharmacy, Desh Bhagat University, Punjab, India-147301

Keywords:

Depression, Raspberry ketone, Insilico, Molecular Docking, Pharmacokinetics,, Bioisosteric

Abstract

After analyzing multiple pharmaceutical databases like ScienceDirect, PubMed, Google Scholar, and others, it was discovered that RK has yet to be linked to any anti-depressant action. The primary goal of this work was to use in-silico techniques to investigate the anti-depressant capability of RK against three major targets (monoamine oxidases, MAOs; human serotonin transporter, SERT; and serotonin receptors, 5HTs). Moreover, prediction of drug-likeliness, bioavailability, and pharmacokinetics of RK has been done using online computational tools (SwissADME, SwissTargetPrediction, and SwissBioisostere). Thein silico study indicated the emerging role of RK in the management of clinical depression. The pharmacokinetic studies, target prediction studies against 3 species, and biosisosteric-based studies also supported the possibilities of lead development. The study will open new avenues of application of this low-molecular-weight-ligand (LMWL) for the clinicians, chemists, and other scientific professionals in context to emerging depression challenges.

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References

Tripathi KD, 2013. Essentials of medical pharmacology. 7th ed.,New Delhi, JP Medical Ltd.pp. 410-412.

Goodman LS, 1996. Goodman and Gilman's the pharmacological basis of therapeutics. New York, McGraw-Hill.pp. 96-98.

Kar A, 2005. Medicinal chemistry. 3rd ed., New Delhi, New Age International. pp. 232-233.

Foye WO, 2008. 7th ed.,Foye's Principles of Medicinal Chemistry. Philadelphia,Lippincott Williams & Wilkins.pp. 141-143.

Alagarsamy V, 2013. 2nd ed., Textbook of Medicinal Chemistry. New York, Elsevier Health Sciences. pp. 177-178.

Ulbricht C, Catapang M, Conquer J, et al, 2013. Raspberry Ketone: an evidence-based systematic review by the natural standard research collaboration. Altern Complement Ther, 19(2), 98-100.

Rao S, Kurakula M, Mamidipalli N, et al, 2021. Pharmacological exploration of phenolic compound: raspberry ketone—update 2020. Plants, 10(7), 1323.

Lim SH, Choi CI, 2021. Potentials of Raspberry Ketone as a Natural Antioxidant. Antioxidants, 10(3), 482.

Joseph TM, Mahapatra DK, 2018. Bacterial DNA Gyrase (Topoisomerase) Inhibitory Potentials of Heterocyclic Natural Products: Investigations through Induced-Fit Molecular Docking Approach. Res Rev JDrug Design Discov,5(2), 7-9.

Joseph TM, Mahapatra DK, 2020. Exploration of two natural inhibitors for treating COVID-19 from simple natural products: nature probably has all the Solutions. J Public Health Sanit, 1(1), 17-24.

Joseph TM, Sharanya CS, Mahapatra DK, et al, 2018. In vitro Assessment of Selected Benzoic Acid Derivatives as Anti-inflammatory Compounds. J Scient Indus Res, 77(6), 330-336.

Joseph TM, Mahapatra DK, 2017. In silico molecular docking of cuminaldehyde and its bioconverted ligands as lipoxygenase and cyclooxygenase-2 inhibitors. Inventi Impact Mol Model, 2017(3), 118-121.

Joseph TM, Mahapatra DK, 2020. Exploring the 5-Lipoxygenase Inhibitory Potentials of Gossypetin 8-glucuronide through In-Silico Approach. InnovatJ Med Sci, 4(2), 1-4.

Joseph TM, Mahapatra DK, 2018. 5-Lipoxygenase and Phospholipase A2 inhibitory potentials of alcoholic extract of Cyperus rotundus: In vitro and in silico study. Res RevJ Pharmacol, 8(2), 1-5.

Lee J, 2016. Further research on the biological activities and the safety of raspberry ketone is needed. NFS J, 2, 15-8.

Bredsdorff L, Wedebye EB, Nikolov NG, et al, 2015. Raspberry ketone in food supplements–High intake, few toxicity data–A cause for safety concern?. Regul Toxicol Pharmacol,73(1), 196-200.

Guo H, Chang S, Jia L, et al, 2021. Advances in the synthesis and applications of raspberry ketone: A review. Flavour Fragr J,36(6), 615-25.

Li X, Wei T, Wu M, et al, 2022. Potential metabolic activities of raspberry ketone. J Food Biochem, 46(1), e14018.

Singh S, Virmani T, Kohli K, 2020. Phytochemicals and Medicinal Uses of Red Raspberry: A Review. J Pharmaceut Res, 5(2), 48-52.

Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Get vaccinated when it is your turn and follow the local guidelines. International Journal of Health Sciences, 5(3), x-xv. https://doi.org/10.53730/ijhs.v5n3.2938

Published

19-07-2022

How to Cite

Kumar, S., Kumar, S., Garg, A., Sethy, S., & Gulati, P. (2022). Raspberry ketone: an emerging molecule for treating depression and associated symptoms - molecular docking and pharmacokinetics studies . International Journal of Health Sciences, 6(S7), 195–208. https://doi.org/10.53730/ijhs.v6n7.10811

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Peer Review Articles

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