Raspberry ketone: an emerging molecule for treating depression and associated symptoms - molecular docking and pharmacokinetics studies
Keywords:
Depression, Raspberry ketone, Insilico, Molecular Docking, Pharmacokinetics,, BioisostericAbstract
After analyzing multiple pharmaceutical databases like ScienceDirect, PubMed, Google Scholar, and others, it was discovered that RK has yet to be linked to any anti-depressant action. The primary goal of this work was to use in-silico techniques to investigate the anti-depressant capability of RK against three major targets (monoamine oxidases, MAOs; human serotonin transporter, SERT; and serotonin receptors, 5HTs). Moreover, prediction of drug-likeliness, bioavailability, and pharmacokinetics of RK has been done using online computational tools (SwissADME, SwissTargetPrediction, and SwissBioisostere). Thein silico study indicated the emerging role of RK in the management of clinical depression. The pharmacokinetic studies, target prediction studies against 3 species, and biosisosteric-based studies also supported the possibilities of lead development. The study will open new avenues of application of this low-molecular-weight-ligand (LMWL) for the clinicians, chemists, and other scientific professionals in context to emerging depression challenges.
Downloads
References
Tripathi KD, 2013. Essentials of medical pharmacology. 7th ed.,New Delhi, JP Medical Ltd.pp. 410-412.
Goodman LS, 1996. Goodman and Gilman's the pharmacological basis of therapeutics. New York, McGraw-Hill.pp. 96-98.
Kar A, 2005. Medicinal chemistry. 3rd ed., New Delhi, New Age International. pp. 232-233.
Foye WO, 2008. 7th ed.,Foye's Principles of Medicinal Chemistry. Philadelphia,Lippincott Williams & Wilkins.pp. 141-143.
Alagarsamy V, 2013. 2nd ed., Textbook of Medicinal Chemistry. New York, Elsevier Health Sciences. pp. 177-178.
Ulbricht C, Catapang M, Conquer J, et al, 2013. Raspberry Ketone: an evidence-based systematic review by the natural standard research collaboration. Altern Complement Ther, 19(2), 98-100.
Rao S, Kurakula M, Mamidipalli N, et al, 2021. Pharmacological exploration of phenolic compound: raspberry ketone—update 2020. Plants, 10(7), 1323.
Lim SH, Choi CI, 2021. Potentials of Raspberry Ketone as a Natural Antioxidant. Antioxidants, 10(3), 482.
Joseph TM, Mahapatra DK, 2018. Bacterial DNA Gyrase (Topoisomerase) Inhibitory Potentials of Heterocyclic Natural Products: Investigations through Induced-Fit Molecular Docking Approach. Res Rev JDrug Design Discov,5(2), 7-9.
Joseph TM, Mahapatra DK, 2020. Exploration of two natural inhibitors for treating COVID-19 from simple natural products: nature probably has all the Solutions. J Public Health Sanit, 1(1), 17-24.
Joseph TM, Sharanya CS, Mahapatra DK, et al, 2018. In vitro Assessment of Selected Benzoic Acid Derivatives as Anti-inflammatory Compounds. J Scient Indus Res, 77(6), 330-336.
Joseph TM, Mahapatra DK, 2017. In silico molecular docking of cuminaldehyde and its bioconverted ligands as lipoxygenase and cyclooxygenase-2 inhibitors. Inventi Impact Mol Model, 2017(3), 118-121.
Joseph TM, Mahapatra DK, 2020. Exploring the 5-Lipoxygenase Inhibitory Potentials of Gossypetin 8-glucuronide through In-Silico Approach. InnovatJ Med Sci, 4(2), 1-4.
Joseph TM, Mahapatra DK, 2018. 5-Lipoxygenase and Phospholipase A2 inhibitory potentials of alcoholic extract of Cyperus rotundus: In vitro and in silico study. Res RevJ Pharmacol, 8(2), 1-5.
Lee J, 2016. Further research on the biological activities and the safety of raspberry ketone is needed. NFS J, 2, 15-8.
Bredsdorff L, Wedebye EB, Nikolov NG, et al, 2015. Raspberry ketone in food supplements–High intake, few toxicity data–A cause for safety concern?. Regul Toxicol Pharmacol,73(1), 196-200.
Guo H, Chang S, Jia L, et al, 2021. Advances in the synthesis and applications of raspberry ketone: A review. Flavour Fragr J,36(6), 615-25.
Li X, Wei T, Wu M, et al, 2022. Potential metabolic activities of raspberry ketone. J Food Biochem, 46(1), e14018.
Singh S, Virmani T, Kohli K, 2020. Phytochemicals and Medicinal Uses of Red Raspberry: A Review. J Pharmaceut Res, 5(2), 48-52.
Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Get vaccinated when it is your turn and follow the local guidelines. International Journal of Health Sciences, 5(3), x-xv. https://doi.org/10.53730/ijhs.v5n3.2938
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.
