Developing the analytical methods for the assay of anthelmintics (Albendazole) and anti- tuberculosis agents (Ethionamide) by utilizing two CT reagents - iodine and picric acid

Saurabh Savita; Niyati Shrivastava; Sunil Kumar; Vinay Kumar Siroliya; Varsha Yadav; Prachi Gupta

doi:10.53730/ijhs.v6nS3.8214

Developing the analytical methods for the assay of anthelmintics (Albendazole) and anti- tuberculosis agents (Ethionamide) by utilizing two CT reagents - iodine and picric acid

https://doi.org/10.53730/ijhs.v6nS3.8214

Authors

Saurabh Savita
saurabhsavi93@gmail.com
Institute of Pharmacy, PK University, Thanra - 473665, Madhya Pradesh, India
Niyati Shrivastava Institute of Pharmacy, PK University, Thanra - 473665, Madhya Pradesh, India
Sunil Kumar Institute of Pharmacy, PK University, Thanra - 473665, Madhya Pradesh, India
Vinay Kumar Siroliya Institute of Pharmacy, PK University, Thanra - 473665, Madhya Pradesh, India
Varsha Yadav Institute of Pharmacy, PK University, Thanra - 473665, Madhya Pradesh, India
Prachi Gupta Institute of Pharmacy, PK University, Thanra - 473665, Madhya Pradesh, India

Keywords:

anthelmintics, anti- tuberculosis, albendazole, ethionamide, iodine, picric acid

Abstract

Introduction - Rifampin, isoniazid, pyrazinamide, and ethambutol are antitubercular drugs that have been licenced by the FDA for the treatment of Mycobacterium tuberculosis infections. Antitubercular medicines are drugs that are used to treat tuberculosis. The term "anthelmintic" refers to a medicine used to treat parasitic worm infestations in animals. This comprises both flat and round worms, such as flukes (trematodes) and tapeworms (cestodes) (nematodes). Aim of this study - The primary aim of this research is to develop and validate simple, fast, reliable, robustness and ruggedness analytical procedures for anthelmintics (ALB) and antitubercular (ETH) medicines. Material and Methods - Two CT reagents, iodine and picric acid, were used to produce two simple and somewhat sensitive Albendazole (ALB) and Ethionamide (ETN) techniques. The CT complex with the placebo blank had almost the same absorbance as the reagent blank, indicating that there was no interference by using Systronics model 166 digital spectrophotometer tools. Organic solvents were employed to dissolve all of the chemicals, which were of analytical reagent grade.

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References

Conterno, L. O., Turchi, M. D., Corrêa, I., & Monteiro de Barros Almeida, R. A. (2020). Anthelmintic drugs for treating ascariasis. The Cochrane database of systematic reviews, 4(4), CD010599. https://doi.org/10.1002/14651858.CD010599.pub2

Yan Lin, et al (2020) -Synthesis, characterization and antiparasitic activity of organometallic derivatives of the anthelmintic drug albendazole. Dalton Trans., 2020,49, 6616-6626

Patel, C., Hürlimann, E., Keller, L. et al. Efficacy and safety of ivermectin and albendazole co-administration in school-aged children and adults infected with Trichuris trichiura: study protocol for a multi-country randomized controlled double-blind trial. BMC Infect Dis 19, 262 (2019). https://doi.org/10.1186/s12879-019-3882-x

Patil, Yogesh & Darvekar, Kavita & Kher, J. & Deshpande, M.. (2017). Studies on development of antituberculosis agents. International Journal of Engineering and Technical Research. 4.

Scardigli, Anna & Caminero, Jose & Sotgiu, Giovanni & Centis, Rosella & D'Ambrosio, Lia & Migliori, Giovanni Battista. (2016). Efficacy and tolerability of ethionamide versus prothionamide: A systematic review. European Respiratory Journal. 48. ERJ-00438. 10.1183/13993003.00438-2016.

N. Swamy, K.N. Prashanth and K. Basavaiah, Analytical utility of potassium permanganate for the assay of albendazole in bulk drug and pharmaceuticals, J. Reports Pharm. Sci. 4(1), 2015, 12.

LCGC Editors, Emerging Trends in Pharmaceutical Analysis, LCGC on 17 March 18, 2015

Yadav, Piyush & Singh, Rupali. (2011). A review on anthelmintic drugs and their future scope. International Journal of Pharmacy and Pharmaceutical Sciences. 3. 17-21.

Deokate, Uday & Lahane, & Ahire, Sujeetkumar & Lahane-Ahire, Sandhya. (2020). Review on Anthelmintic Drugs. Pharma Research.

Kumar, Vicky & Junaid, Mohd & Kesri, Kuldeep & Kushawah, Deepak. (2020). INTRODUCTION OF TUBERCULOSIS DISEASE AND CLASSIFICATION OF ANTI TUBERCULOSIS DRUGS. 10.20959/wjpps20194-13496.

Bocanegra-Garci?a, Virgilio & Garci?a, Abraham & Palma-Nicolás, José & Palos, Isidro & Rivera, Gildardo. (2011). Antitubercular Drugs Development: Recent Advances in Selected Therapeutic Targets and Rational Drug Design. 10.5772/27735.

Dwivedi S, Mahor A, Chanchal D. Chitosan nanoparticles: A review. World J Pharm Pharm Sci. 2015 Nov 9; 5: 433-9.

Rashi S, Singh D, Chanchal DK, Singh M, Anand S, Alok S. Cubosomes: a bicontinuous cubic crystalline phase. International Journal of Life Sciences and Review. 2015; 1(10): 291-301.

Published

31-05-2022

How to Cite

Savita, S., Shrivastava, N., Kumar, S., Siroliya, V. K., Yadav, V., & Gupta, P. (2022). Developing the analytical methods for the assay of anthelmintics (Albendazole) and anti- tuberculosis agents (Ethionamide) by utilizing two CT reagents - iodine and picric acid. International Journal of Health Sciences, 6(S3), 9386–9401. https://doi.org/10.53730/ijhs.v6nS3.8214

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Issue

Vol. 6 No. S3 (2022)

Section

Peer Review Articles

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