Association of anti thyroid peroxidase antibody with thyroid profile in the patients of subclinical hypothyroidism
Keywords:
subclinical hypothyroidism, TSH, anti-TPO antibodyAbstract
Background: Thyroid is an endocrine gland which is ductless and plays very important roles such as metabolism of body along with maturation and growth. Subclinical Hypothyroidism is a mild form of Hypothyroidism which due to the abnormal level of TSH. Objectives: The aim of the study was to find out the correlation of anti-TPO antibody with thyroid profile in subclinical hypothyroidism. Materials and Methods: The present study was conducted on 200 cases and 200 controls who attended the OPD of Shri Guru Ram rai Institute of Medical and Health Sciences, Dehradun. The various Biochemical investigation (TSH, FT3, FT4 & Anti- TPO) of these patients were analyzed by ELISA Method with standard protocol. Data analyzed statistically by SPSS software. Results: The study observed TSH and Anti-TPO antibody level was statistically higher (p-value= <0.05) in cases as compared to control. Free T3 and Free T4 value was in normal range in both subjects. Anti-TPO antibody has positive correlation with THS. Conclusion: Out of all the investigations and observations only record of TSH is the definite prognostic marker to ensure that the patients have subclinical hypothyroidism.
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