Study of association among various atherosclerotic risk factors in patients of subclinical hypothyroidism
Abstract
Background & Objectives: Subclinical hypothyroidism is endocrine disorder where serum TSH levels are increased but FT4 levels are within the assay's reference interval. Atherosclerosis has been found to be associated with the increased level of Ox-LDL in SCH. The aim of the present study is to find out the association of Ox-LDL and lipid profile in SCH patients. Materials and methods: 120 SCH patients aged (18-70) years and 120 age & sex-matched healthy controls were included in the study. BMI & lipid profile were estimated in both SCH patients and controls. FT3, FT4, TSH and Ox-LDL) were estimated by enzyme-linked immunosorbent assay. Results: SCH patients and healthy controls had different BMIs (p<0.001). TC, Triglycerides, HDL-C, and LDL-C were significantly greater in the SCH group than in the control group, although HDL-C was decreased (p<0.001). SCH patients had a significantly higher blood TSH level than controls (p<0.001), although FT3 and FT4 levels were similar. SCH patients had higher Ox-LDL than controls (p<0.001). Conclusion: In our study, SCH patients had higher serum lipid profile and Ox-LDL levels than healthy persons, indicating susceptibility to atherosclerosis. Ox-LDL can be used to predict CVD risk in SCH patients.
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Abdel-Gayoum, A. A. (2014). Dyslipidemia and serum mineral profiles in patients with thyroid disorders. Saudi Medical Journal, 35(12), 1469–1476.
Akinci, B., Comlekci, A., Yener, S., Demir, T., Bayraktar, F., Yuksel, F., & Yesil, S. (2007). The alteration of serum soluble CD40 ligand levels in overt and subclinical hypothyroidism. Hormones (Athens, Greece), 6(4), 327–333. https://doi.org/10.14310/horm.2002.1111029
Anand, A. K., & Mustafa, A. (2022). Role of adenosine deaminase in dyslipidemia. International Journal of Health Sciences, 6(S4), 5752–5758. https://doi.org/10.53730/ijhs.v6nS4.10167
Aziz, M., Kandimalla, Y., Machavarapu, A., Saxena, A., Das, S., Younus, A., Nguyen, M., Malik, R., Anugula, D., Latif, M. A., Humayun, C., Khan, I. M., Adus, A., Rasool, A., Veledar, E., & Nasir, K. (2017). Effect of thyroxin treatment on carotid intima–media thickness (CIMT) reduction in patients with subclinical hypothyroidism (SCH): A meta-analysis of clinical trials. Journal of Atherosclerosis and Thrombosis, 24(7), 643–659. https://doi.org/10.5551/jat.39917
Cebeci, E., Oner, F. A., Usta, M., Yurdakul, S., & Erguney, M. (2011). Evaluation of oxidative stress, the activities of paraoxonase and arylesterase in patients with subclinic hypothyroidism. Acta Biomedica, 82(3), 214–222.
Cerbone, M., Capalbo, D., Wasniewska, M., Alfano, S., Raso, G. M., Oliviero, U., Cittadini, A., de Luca, F., & Salerno, M. (2016). Effects of L-thyroxine treatment on early markers of atherosclerotic disease in children with subclinical hypothyroidism. European Journal of Endocrinology, 175(1), 11–19. https://doi.org/10.1530/EJE-15-0833
Duntas, L. H., Mantzou, E., & Koutras, D. A. (2002). Circulating levels of oxidized low-density lipoprotein in overt and mild hypothyroidism. Thyroid, 12(11), 1003–1007. https://doi.org/10.1089/105072502320908349
Farghaly, H. S., Metwalley, K. A., Raafat, D. M., Algowhary, M., & Said, G. M. (2020). Epicardial Fat Thickness in Children with Subclinical Hypothyroidism and Its Relationship to Subclinical Atherosclerosis: A Pilot Study. Hormone Research in Paediatrics, 92(2), 99–105. https://doi.org/10.1159/000503287
Gao, C. X., Yang, B., Guo, Q., Wei, L. H., & Tian, L. M. (2015). High thyroid-stimulating hormone level is associated with the risk of developing atherosclerosis in subclinical hypothyroidism. Hormone and Metabolic Research, 47(3), 220–224. https://doi.org/10.1055/s-0034-1394370
Gazdag, A., Nagy, E. v., Burman, K. D., Paragh, G., & Jenei, Z. (2010). Improved endothelial function and lipid profile compensate for impaired hemostatic and inflammatory status in iatrogenic chronic subclinical hyperthyroidism of thyroid cancer patients on L-Ttherapy. Experimental and Clinical Endocrinology and Diabetes, 118(6), 381–387. https://doi.org/10.1055/s-0029-1224156
Geng, H., Zhang, X., Wang, C., Zhao, M., Yu, C., Zhang, B., Wang, Y., Ban, B., & Zhao, J. (2015). Even mildly elevated TSH is associated with an atherogenic lipid profile in postmenopausal women with subclinical hypothyroidism. Endocrine Research, 40(1), 1–7. https://doi.org/10.3109/07435800.2013.879166
Harada, P. H. N., Buring, J. E., Cook, N. R., Cobble, M. E., Kulkarni, K. R., & Mora, S. (2017). Impact of subclinical hypothyroidism on cardiometabolic biomarkers in women. Journal of the Endocrine Society, 1(2), 113–123. https://doi.org/10.1210/js.2016-1085
Holvoet, P. (2004). Oxidized LDL and coronary heart disease. Acta Cardiologica, 59(5), 479–484. https://doi.org/10.2143/AC.59.5.2005219
Holvoet, P., Harris, T. B., Tracy, R. P., Verhamme, P., Newman, A. B., Rubin, S. M., Simonsick, E. M., Colbert, L. H., & Kritchevsky, S. B. (2003). Association of high coronary heart disease risk status with circulating oxidized LDL in the well-functioning elderly: Findings from the health, aging, and body composition study. Arteriosclerosis, Thrombosis, and Vascular Biology, 23(8), 1444–1448. https://doi.org/10.1161/01.ATV.0000080379.05071.22
Jayasingh, I., & Puthuran, P. (2016). Subclinical hypothyroidism and the risk of hypercholesterolemia. Journal of Family Medicine and Primary Care, 5(4), 809. https://doi.org/10.4103/2249-4863.201177
Karvonen, J., Päivänsalo, M., Kesäniemi, Y. A., & Hörkkö, S. (2003). Immunoglobulin M Type of Autoantibodies to Oxidized Low-Density Lipoprotein Has an Inverse Relation to Carotid Artery Atherosclerosis. Circulation, 108(17), 2107–2112. https://doi.org/10.1161/01.CIR.0000092891.55157.A7
Kumar Shah, A., Sarin, M., Karunanand, B., Mohapatra, S., & Ahmad Bhat, S. (2017). Association of Hormonal status with Anthropometric & Biochemical Parameters in women with Polycystic Ovarian Syndrome. The Journal of Community Health Management, 4(1), 30. https://doi.org/10.18231/2394-2738.2017.0006
Laway, B. A., War, F. A., Shah, S., Misgar, R. A., & Kotwal, S. K. (2014). Alteration of lipid parameters in patients with subclinical hypothyroidism. International Journal of Endocrinology and Metabolism, 12(3), 10–13. https://doi.org/10.5812/ijem.17496Duntas, L. H., Mantzou, E., & Koutras, D. A. (2002). Circulating levels of oxidized low-density lipoprotein in overt and mild hypothyroidism. Thyroid, 12(11), 1003–1007. https://doi.org/10.1089/105072502320908349
Lee, Y. K., Kim, J. E., Oh, H. J., Park, K. S., Kim, S. K., Park, S. W., Kim, M. J., & Cho, Y. W. (2011). Serum TSH level in healthy koreans and the association of TSH with serum lipid concentration and metabolic syndrome. Korean Journal of Internal Medicine, 26(4), 432–439. https://doi.org/10.3904/kjim.2011.26.4.432
Loh, H. H., Lim, L. L., Yee, A., & Loh, H. S. (2019). Association between subclinical hypothyroidism and depression: an updated systematic review and meta-analysis. BMC Psychiatry, 19(1), 1–10. https://doi.org/10.1186/s12888-018-2006-2
Nuriyasa, I. M., Puspani, E., & Yupardhi, W. S. (2018). Growth and blood profile of lepus nigricollis fed diet fermented coffee skin in different levels. International Journal of Life Sciences, 2(1), 21–28. https://doi.org/10.29332/ijls.v2n1.83
Santi, A., Duarte, M. M. M. F., de Menezes, C. C., & Loro, V. L. (2012). Association of lipids with oxidative stress biomarkers in subclinical hypothyroidism. International Journal of Endocrinology, 2012. https://doi.org/10.1155/2012/856359
Sanyal, D., & Raychaudhuri, M. (2016). Hypothyroidism and obesity: An intriguing link. Indian Journal of Endocrinology and Metabolism, 20(4), 554–557. https://doi.org/10.4103/2230-8210.183454.
Shoji, T., Nishizawa, Y., Fukumoto, M., Shimamura, K., Kimura, J., Kanda, H., Emoto, M., Kawagishi, T., & Morii, H. (2000). Inverse relationship between circulating oxidized low density lipoprotein (oxLDL) and anti-oxLDL antibody levels in healthy subjects. Atherosclerosis, 148(1), 171–177. https://doi.org/10.1016/S0021-9150(99)00218-X
Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). The COVID-19 pandemic. International Journal of Health Sciences, 5(2), vi-ix. https://doi.org/10.53730/ijhs.v5n2.2937
Turhan, S., Sezer, S., Erden, G., Guctekin, A., Ucar, F., Ginis, Z., Ozturk, O., & Bingol, S. (n.d.). Plasma homocysteine concentrations and serum lipid profile as atherosclerotic risk factors in subclinical hypothyroidism. www.saudiannals.net
Virgini, V. S., Wijsman, L. W., Rodondi, N., Bauer, D. C., Kearney, P. M., Gussekloo, J., den Elzen, W. P. J., Jukema, J. W., Westendorp, R. G. J., Ford, I., Stott, D. J., & Mooijaart, S. P. (2014). Subclinical thyroid dysfunction and functional capacity among elderly. Thyroid, 24(2), 208–214. https://doi.org/10.1089/thy.2013.0071
Zhu, C., Gao, J., Mei, F., Lu, L., Zhou, D., & Qu, S. (2019). Reduction in Thyroid-Stimulating Hormone Correlated with Improved Inflammation Markers in Chinese Patients with Morbid Obesity Undergoing Laparoscopic Sleeve Gastrectomy. Obesity Surgery, 29(12), 3954–3965. https://doi.org/10.1007/s11695-019-04063-4
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