Immunological detection using immune cytokines for human cutaneous leishmaniasis in Al-Najaf Al-Ashraf governorate
Keywords:
immunological detection, immune cytokines, humanAbstract
The results of the immunofluorescence study with ELISA technique showed ELIZA for sera of patients with leishmaniasis L. Major Significant increase in cellular kinetics values, as interleukin reached 6 (IL6) 4.45±3.2 pg | ml, tumor necrosis factor factor -a) 0.32 ± 0.15 pg | The statistical study recorded a significant increase at the p<0.05 probability level with the control group samples. The laboratory results of hematological covariance assays recorded a significant decrease at p<0.05 in the hemoglobin level Hb reached (12.2±1.1 g | deciles compared to the control group 15.9 ± 0.66) g | Decylase، white blood cells, neutrophils and lymphocytes were significantly elevated at p<0.05 when compared with the control group.
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Abu Dawanij , Hassan Zaati Abadi 2014 ) A study of some epidemiological aspects of leishmaniasis . Leishmaniasis and Parasite Diagnosis Using Nested -Kinetoplast Polymerase Chain Reaction Technique Minicircle DNA-PCR In Maysan Governorate, Master Thesis, College of Education for Pure Sciences, University of Basra - Iraq.
Al Shukr, Ban Shaker Abdul Amir (2012) . Diagnosis of cutaneous leishmaniasis
Al-Abdullah, Shtiwi (2012) . Physiology, first edition. Dar Al-Masira for Publishing and Distribution, Amman, Jordan.
Al-Hassani, Mohamed Kamel Karim Taher (2020) Study of the levels of some trace elements in blood serum and their relationship with some antioxidant enzymes and immune factors in patients with cutaneous leishmaniasis and white rats . PhD thesis. Faculty of Education. Al-Qadisiyah University.
Al-Moussawi, Azhar Musa Jaafar (2015) . Molecular and Immunological Study of Cutaneous Leishmania in Central and Southern Governorates . PhD thesis . College of Education for Pure Sciences. Karbala University.
Al-Musawi, Nabil Abdul-Jabbar Abdul-Kadhim ( 2015 ) Investigation of cutaneous leishmaniasis and knowledge of the role of heat shock protein HSP70 in the immune response in Dhi Qar Governorate, Master's thesis, College of Education for Pure Sciences, University of Dhi Qar, Iraq.
Azpurua J, De La Cruz D, Valderama A, Windsor D. Lutzomyia sandfly diversity and rates of infection by Wolbachia and an exotic Leishmania species on Barro Colorado Island, Panama. PLOS Negl Trop Dis. 2010; 4: e627, doi : to. 1371 PMID: 20231892 .
Baaten BJ, Tinoco R, Chen AT, Bradley LM: Regulation of Antigen-Experienced T Cells: Lessons from the Quintessential Memory Marker CD44. Frontiers in immunology 2012, 3:23 .
Babiker , MAA Determination of Some Micronutrients In Traditional Sudanese Food. Sudan University of Science and Technology.
Banerjee, S., Bose, D., Chatterjee , N., Das, S., Chakraborty , S., Das, T., & Saha , KD (2016). Attenuated Leishmania induce proinflammatory mediatös and influence leishmanicidal activity by p38 MAPK dependent phagosome maturation in Leishmania donovani co-infected macrophages. Scientific Reports, 6(1), 1-14.
Barazesh , A., Motazedian , MH, Sattarahmady , N., Morowvat , MH, & Rashidi , S. (2018). Preparation of megalumine antimonate loaded albumin nanoparticles and evaluation of its anti- leishmanial activity: an in vitro assay. Journal of Parasitic Diseases, 42(3), 416-422.
Barbosa, FMC, Dupin , TV, Toledo, MDS, Reis, NFDC, Ribeiro , K., Cronemberger -Andrade, A., et al. (2018). Extracellular vesicles released by leishmania ( Leishmania ) amazonensis promote disease progression and induce the production of different cytokines in macrophages and Bl cells. Front. Microbiol . 9, 1—14. doi : 10.3389/ fmicb . 2018. 03056
Barrera, P.; Sülsen , VP; Lozano, E.; Rivera, M.; Beer, M.F.; Tonn , C.; Martino, VS; Sosa, MA Natural Sesquiterpene Lactones Induce Oxidative Stress in Leishmania Mexicana . Evid . Based Complement. Alternate . Med. 2013, 2013, 163404. [ CrossRef ] [PubMed]
Ben Salah A, Ben Messaoud N, Guedri E, Zaatour A, Ben Alaya N, et al (2013) Topical paromomycin with or without gentamicin for cutaneous leishmaniasis . N Engl J Med 368: 524-532.
Ben Salah A, Ben Messaoud N, Guedri E, Zaatour A. Ben Alaya N. et al. Topical paromomycin with or without gentamicin for cutaneous leishmaniasis . N Engl J Med 368: 524-532 .
Bhattacharya, PT, Misra SR, & Hussain , M. (2016). Nutritional aspects of essential trace elements in oral health and disease: an extensive review. Scientifica , 2016.
Bhattarai NR, Dujardin JC, Rijal S, De Doncker S, Boelaert M, Van der Auwera G: Development and evaluation of different PCR-based typing methods for discrimination of Leishmania donovani isolates from Nepal. Parasitology 2010 , 137(6): 947-957.
Bianchi, C., Kostygov , AY, Kraeva , N., Zåhonovå , K., Horåkovå , E., Sobotka , R., Yurchenko , V. (2019). An enigmatic catalase of Blastocrithidia . Molecular and Biochemical Parasitology, 232, 1 1 1 199.
Bianchi, S., Bernardi , S., Continenza , MA, Vincenti , E., Antonouli , S., Torge , D., & Macchiarelli , G. (2020). Scanning electron microscopy approach for evaluation of hair dyed with Lawsonia inermis powder: in vitro study. Int. j. morphol , 38(1), 96-100.
Biswas , A., French, T., Düsedau , HP, Mueller, N., Riek-Burchardt , M. Dudeck , A., Dunay , IR (2017). Behavior of neutrophil granulocytes during Toxoplasma gondii infection in the central nervous system. Frontiers in cellular and infection microbiology, 7, 259
Blazkova , J., Gupta, S., Liu, Y., Gaudilliere , B., Ganio , EA, Bolen, CR Hasni , S. (2017). Multicenter systems analysis of human blood reveals immature neutrophils in males and during pregnancy. The Journal of Immunology, 198(6), 2479-2488.
Boelaert M, Sundar S. (2014). Leishmaniasis . In: Farrer J, Hotez P, Junghanss T, Kang G, Lalloo D, White NJ, editors. Manson's Tropical Infectious Diseases. 23rd ed. Philadelphia: Elsevier Saunders. p. 631—51.
Browne, N., Heelan , M., & Kavanagh, K. (2013). An analysis of the structural and functional similarities of insect hemocytes and mammalian phagocytes. Virulence, 4(7), 597-603.
Bualert L, Charungkiattikul W, Thongsuksai P, Mungthin M, Siripattanapipong S, Khositnithikul R, et al. Autochthonous disseminated dermal and visceral leishmaniasis in an AIDS patient, southern Thailand, caused by Leishmania siamensis . Am J Trop Med Hyg . 2012; 86: 821—824. doi : 10.4269/ajtmh.2012.11-0707 PMID: 22556080.
Cabello- Donayre , M., Malagarie-Cazenave , S., Campos-Salinas, J., Gålvez , FJ, Rodriguez-Martinez, A., Pineda-Molina, E., Estévez , AM (2016). Trypanosomatid parasites rescue heme from endocytosed hemoglobin through lysosomal HRG transporters. Molecular Microbiology, 101(6), 895-908.
Calderón Guzmán , D., Juárez Olguin , H., Osnaya Brizuela , N., Hernåndez Garcia, E., & Lindoro Silva, M. (2019). The use of trace and essential elements in common clinical disorders: roles in assessment of health and oxidative stress status. Nutrition and cancer, 71 (l), 1320.
Campos, TM, Novais , FO, Saldanha , M., Costa, Re, Lordelo , M., Celestino , D., Machado, P. (2020). Granzyme B produced by natural killer cells enhances inflammatory response and contributes to the immunopathology of cutaneous leishmaniasis . The Journal of Infectious Diseases, 221 (6), 973-982.
Carneiro , PP, Conceiqäo , J., Macedo , M., Magalhäes , V., Carvalho , E. Me, & Bacellar , O. (2016). The role of nitric oxide and reactive oxygen species in the killing of Leishmania braziliensis by monocytes from patients with cutaneous leishmaniasis . Plos one, I I e0148084.
Castanys -Munoz E, Brown E, Coombs GH, Mottram JC: Leishmania mexican metacaspase is a negative regulator of amastigote proliferation in mammalian cells. Cell death & disease 2012, 3:e385 .
Celes , FS, Trovatti , E., Khouri , R., Van Weyenbergh , J., Ribeiro , SJ, Borges, VM, De Oliveira, C. 1. (2016). DETC-based bacterial cellulose bio-curatives for topical treatment of cutaneous leishmaniasis . Scientific Reports, 6(1), I -I l.
Chakrabarti , S.; Sarkar , S.; Goswami , BK (2013): Clinico-haematological Profile of visceral leishmaniasis in immunocompetent patients. Southeast Asian J Trop Med Public Health. 44: 143-149.
Chatterjee , N., Das, S., Bose, D., Banerjee, S., Jha , T., & Saha , KD (2015). Leishmanial lipid affords protection against oxidative stress induced hepatic injury by regulating inflammatory mediators and confining apoptosis progress. Toxicology letters, 232(2), 499-512.
Chauhan , P., Shukla , D., Chattopadhyay , D., & Saha , B. (2017). Redundant and regulatow roles for TLRs in Leishmania infection. Clin Exp Immunol ., 10. 1 I l l .
Chen, J., Yu, B., Chen, D., Huang, Z., Mao, X., Zheng , P., He, J. (2018). Chlorogenic acid improves intestinal barrier functions by suppressing mucosa inflammation and improving antioxidant capacity in weaned pigs. The Journal of nutritional biochemistry, 59, 84-92.
Chiku , VM, Silva, KLO, de Almeida, BF Ms , Venturin , GL, Leal, AAC, de Martini, CC, de Lima, VMF (2016). PID-I function in apoptosis of T lymphocytes in canine visceral leishmaniasis . Immunobiology , 221(8), 879-888.
Chu N, Thomas BN, Patel SR, Buxbaum LU: lgG1 is pathogenic in Leishmania mexicana infection .
Cogger , VC, Hunt, NJ, & Le Couteur , DG (2020). Fenestrations in the liver sinusoidal endothelial cell. The Liver: Biology and Pathobiology, 435-443.
Conceicao , J., Davis, R., Carneiro , PP, Giudice , A., Muniz, AC, Wilson, Bacellar , O. (2016). Characterization of neutrophil function in human cutaneous leishmaniasis caused by Leishmania braziliansis . PLoS neglected tropical diseases, 10 (5) .
Covre , LP, Devine, 0., Garcia de Moura , R., Vukmanovic-Stejic , M., Dietze , R., Rodrigues, RR, Akbar, AN (2020). Companmentalized cytotoxic immune response leads to distinct pathogenic roles of natural killer and senescent CD8+ T cells in human cutaneous leishmaniasis . Immunology.
Cunha J (presenting author), Carrillo E, Sånchez C, Tavares J, Moreno J and Cordeiro -da-Silva A: Characterization of the virulence of Leishmania infantum isolates from human patients. Immunology 2012, 137, Issue Supplement sl (Special Issue: Abstracts of the European Congress of Immunology, 5-8 September 2012, Glasgow ,
Cunha J (presenting author), Carrillo E, Sånchez C, Tavares, J, Moreno J and Cordeiro -da-Silva A: Characterization of the virulence of Leishmania infantum isolates from human patients. 3rd European Congress of Immunology, September 5-8, 2012, Glasgow, Scotland, Poster 1168
Cunha J (presenting author), Moreno J and Cordeiro -da-Silva A: Comparative study between naturally attenuated and virulent strains of Leishmania infantum : culture conditions and infectiveness. Acta Parasitolögica Portuguesa 2010, 17(2; Congresso Portugués de Parasitologia , 8-10 September 2010, Porto, Portugal: 97 .
Cunha J (presenting author), Moreno J, Cordeiro -da-Silva A: Comparative study between naturally attenuated and virulent strains of Leishmania infantum : culture conditions and infectiveness. XIV Congress Portugués de Parasitologia 2010, Porto, Portugal, Poster P-31
Cunha J (presenting author), Moreno J, Cordeiro -da-Silva A: In vitro comparative study between naturally attenuated and virulent strains of Leishmania infantum . 2nd 13S Scientific Retreat, May 5-6, 2011, P6voa de Varzim , Portugal, Poster 12
Cunha J, Carrillo E, Sánchez C, Cruz l, Moreno J and Cordeiro -da-Silva A: Characterization of the biology and infectivity of Leishmania infantum Viscerotropic and dermotropic strains isolated from HIV+ and HIV- patients in the murine model of visceral leishmaniasis . Parasites and Vectors 201 3, 6: 122
Cunningham, AF, Flores- Langarica , A., Bobat , S., Dominguez Medina, CC, cook, CN, Ross, EA, Henderson, 1. R. (2014). Bib cells recognize protective antigens after natural infection and vaccination, Frontiers in immunology, 5, 535.
Cutaneous Leishmaniasis by PCR technique with studying the effect of plant extracts on parasite numbers and viability ex vivo. Master's Thesis. College of Education for Girls. University of Kufa
da Silva Vieira, T., Arango Duque, G., Ory , K., Gontijo , CM, Soares , RP, & Descoteaux , A. (2019). Leishmania braziliensis : strainspecific modulation of phagosome maturation. Frontiers in cellular and infection microbiology, 9, 319.
Dafi’i , Rana Saleh Sahib Mahlol ( 2013 ) , The prevalence of cutaneous leishmaniasis in Al-Qadisiyah Governorate with evaluation of the response to treatment with Bent and TTM by RT-PCR , Master’s thesis, College of Education, University of Al-Qadisiyah .
Daham, Amal Kamel and Al- Alusi , Tawfiq Ibrahim (2011) . Epidemiological survey of cutaneous leishmaniasis in Salah El-Din Governorate. Diyala Locality for Agricultural Sciences.
das Dores Moreira, N., Vitoriano -Souza, J., Roatt BM, de Abreu Vieira, PM, Coura -Vital , W., de Oliveira Cardoso, JM Carneiro , CM (2016). Clinical, hematological and biochemical alterations in hamster ( Mesocricetus auratus ) experimentally infected with Leishmania infantum through different routes of inoculation. Parasites & vectors, 9(1), 181.
Das, M., & Das, R. (2013). Effect of Modern Instructional Aids for Developing Awareness Towards Zinc Deficiency Among Rural Females of Sagar District, Madhya Pradesh, India.
De Freitas , EO; Leoratti , FM; Freire -de-Lima, CG; Morrot , A.; Feij6, DF The Contribution of Immune Evasive Mechanisms to Parasite Persistence in Visceral Leishmaniasis . Front. Immunol . 2016, 7, 153. [ CrossRef ] [PubMed]
de Moraes , ARDP, Tavares, GD, Rocha, FJS, de Paula, E., & Giorgio, S. (2018). Effects of nanoemulsions prepared with essential oils of copaiba-and andiroba against Leishmania infantum and Leishmania amazonesis infections. Experimental parasitology, 187, 12-21.
De Oliveira, C I., Brandäo , LO, celes , FS, & Paiva , CN (2019). The paradoxical leishmanicidal effects of Superoxide Dismutase (SOD)mimetic Tempol in Leishmania braziliansis infection in vitro. Frontiers in cellular and infection microbiology, 9, 237.
De Oliveira, CI, Brandäo , LO, celes , FS, & Paiva , CN (2019). The paradoxical leishmanicidal effects of Superoxide Dismutase (SOD)mimetic Tempol in Leishmania braziliansis infection in vitro. Frontiers in cellular and infection microbiology, 9, 237.
De Silva, L., Somaratne , V., Senaratne , S., Vipuladasa , M., Kahatapitiya , S., De Silva, D., Wickremasinghe , R. (2016). Analysis of clinical features with microscopy of cutaneous leishmaniasis suspected patients attending the dermatology clinic at general hospital Hambantota .
De Souza, C. d. SF, Calabrese, K. d. S., Abreu-Silva, AL, Carvalho , LOP, Cardoso, F. d. O., Dorval, M., Pacheco, R. d. S. 2018). Leishmania amazonensis isolated from human visceral leishmaniasis : histopathological analysis and parasitological burden in different inbred mice. Histol Histopathol , 33(7), 705-716.
Deak E, Jayakumar A, Cho KW, Goldsmith- Pestana K, Dondji B, Lambris JD, McMahon-Pratt D: Murine visceral leishmaniasis : lgM and polyclonal B-cell activation lead to disease exacerbation .
Deak E, Jayakumar A, Cho KW, Goldsmith- Pestana K, Dondji B, Lambris JD, McMahon-Pratt D: Murine visceral leishmaniasis : lgM and polyclonal B-cell activation lead to disease exacerbation .
Dennis, S.G. (2018). Engineering Soft Tissue Replacements and the Development of Novel Technologies to Heal These Wounds. Clemson University.
Depledge DP, MacLean LM, Hodgkinson MR, Smith BA, Jackson AP, Ma S, Uliana SR, Smith DF: Leishmania -specific surface antigens show sub-genus sequence variation and immune recognition. PLOS neglected tropical diseases 2010, 4(9):e829 .
Desbois N, Pratlong F, Quist D, Dedet J. Leishmania ( Leishmania ) mattiniquensis n. sp. ( Kinetoplastida : Trypanosomatidae ), description of the parasite responsible for cutaneous leishmaniasis in Martinique Island (French West Indies). Parasite. 2014: 21: 12. doi : 10.1051/parasite/2014011 PMID: 24626346 .
Dostálová A, Volf P. Leishmania development in sandflies: parasite-vector interactions overview. Parasite Vector. 2012; 5: 276-288 .
Dostalova A, Volf P: Leishmania development in sand flies: parasite-vector interactions overview. Parasites & vectors 2012, 5276 .
El - khadragy , M., Aiolayan , EM, Metwally , DM, El-Din, MFS, Alobud , SS, Alsultan , NI, Abdel Moneim , AE (2018). Clinical efficacy associated with enhanced antioxidant enzyme activities of silver nanoparticles biosynthesized using moringa oleifera leaf extract, against cutaneous leishmaniasis in a murine model of leishmania major. International journal of environmental research and public health, 15(5), 1037.
El- Beshbishy HA, Al-Ali KH, El- Badry AA (2013) Molecular characterization of cutaneous Icishmaniasis in Al- Madinah Al- Munawarah province, western Saudi Arabia. Int J Infect ms 17: e334-c338 .
El- Beshbishy HA, Al-Ali KH, El- Badry AA (2013) Molecular characterization of cutaneous leishmaniasis in Al- Madinah Al- Munawarah province, western Saudi Arabia. Int J Infect Dis 17: e334–e338.
El Hajj, R. (2018). Efficacy of the Imiqualine analog EAPB0503 against Cutaneous Leishmaniasis : A promising new treatment paradigm.
Erejuwa , OO, Sulaiman , SA, & Ab Wahab , MS (2013). Evidence in support of potential applications of lipid peroxidation products in cancer treatment. Oxidative Medicine and Cellular Longevity, 2013.
Esmaeeli , S., Hoseinirad , SM, Rajabian , M., Taheri , AR, Berenji , F., & Hashemy , SI (2019). Evaluation of the oxidant-antioxidant balance, isoprostane and quantitative CRP in patients with cutaneous leishmaniasis . Microbial pathogenesis, 137, 103738.
European journal of immunology 2010, 40(5): 1355-1368 .
Evans KJ, Kedzierski L: Development of Vaccines against Visceral Leishmaniasis . Journal of tropical medicine 2012, 2012:892817.
Kashkol, Abbas Hayawi ( 2009 ). Some Environmental and Biological Aspects of Harms Phlebotominae ( Diptea :psychodidae ) and the epidemic of cutaneous leishmaniasis in Al- Diyaniyah governorate . Master.College Sciences . Al- Qadisiyah University: 99 p.
Mayali , Hadi Madlool Hamza (2014) . Evaluation and use of some immunological tests in the epidemiological study of leishmaniasis in Al-Qadisiyah Governorate. PhD thesis . College of Education for Girls, University of Al- Qadisiyah.
Moker, Hanadi Mohsen Mahdi (2006) . Cutaneous leishmaniasis in Basra Governorate, an epidemiological, immunological and therapeutic study, a master's thesis. College of Science, University of Basra.
Parasite, Rasha Amer Nouri (2003) The epidemiology of leishmaniasis and its relationship to the vector insect Harms. stinger Psychodidae : Diptera in Najaf Governorate. Master Thesis . College of Science, University of Kufa.
Salman, Reem Ihsan Youssef (2017) . Study of some immunological aspects and histological effects of patients with cutaneous leishmaniasis in Najaf Governorate. Master Thesis . College of Education for Girls, University of Kufa.
Shaban, Maha and Nahas, Samar (2004) . Epidemiology of cutaneous leishmaniasis for auditors of the Dermatology and Venereology Hospital and Comprehensive Clinics in Damascus. Damascus University Journal of Basic Sciences Volume 19 First Issue: 124-113
Widana, I.K., Sumetri, N.W., Sutapa, I.K., Suryasa, W. (2021). Anthropometric measures for better cardiovascular and musculoskeletal health. Computer Applications in Engineering Education, 29(3), 550–561. https://doi.org/10.1002/cae.22202
Yasiri , Saleh Mahdi (2012) . Study of the relationship of sand fly species with leishmaniasis in Maysan Governorate. Maysan Research Journal, Volume Eight, Issue Sixteen.
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