The correlation of serum uric acid levels with type II diabetic patients
A hospital based pilot study
Keywords:
uric acid, diabetes mellitus, insulin sensitivityAbstract
Aim: To correlate diabetes patients' blood uric acid levels with their duration of diabetes. Materials and methods: This study was conducted on 100 diabetic patients(30-50 years).diabetic patients with no history of any other systemic complications and metabolic disorders like obesity and gout . Each diabetic patient was subjected to detailed general examination. A biochemical investigation for fasting serum uric acid levels estimated. Results: A positive correlation present between SUA and duration of type 2 diabetes is statistically significant. As the duration of diabetes increases than there is an increase in the serum uric acid concentration in type 2 diabetes patients (r = +0.630,p<0.001). Conclusion: Drugs that reduce the serum uric acid level may become effective in preventing the development and prognosis of insulin resistance, a major factor in type 2 diabetes. The significant positive correlation between serum uric acid and the duration of type 2 diabetes suggests the uric acid acts as an independent biochemical marker for type 2 diabetes prognosis.
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A. Dehghan, M. Van Hoek, E. J. G. Sijbrands, A. Hofman, and J. C. M. Witteman, “High serum uric acid as a novel risk factor for type 2 diabetes,” Diabetes Care, vol. 31, no. 2, pp. 361– 362, 2008.
A. Shankar, B. E. K. Klein, F. J. Nieto, and R. Klein, “Association between serum uric acid level and peripheral arterial disease,” Atherosclerosis, vol. 196, no. 2, pp. 749–755, 2008.
A. Shankar, R. Klein, B. E. K. Klein, and F. J. Nieto, “The association between serum uric acid level and long-term incidence of hypertension: population-based cohort study,” Journal of Human Hypertension, vol. 20, no. 12, pp. 937–945, 2006. Am J Med. 1993;1968:359 –365.
Bandaru, Pavani, and Anoop Shankar. “Association between serum uric acid levels and diabetes mellitus.” International journal of endocrinology 2011 (2011).
Bansal BC, Gupta RR, Bansal MR, Prakash C. Serum lipids and uric acid relationship in ischemic thrombotic cerebrovascular disease. Stroke. 1975; 6:304 –307.
Choi HK, De Vera MA, Krishnan E. Gout and the risk of type 2 diabetes among men with a high cardiovascular risk profile. Rheumatology (Oxford, England)., 2008; 47(10): 1567-70.
Crouse JR, Toole JF, McKinney WM, Dignan MB, Howard G, Kahl FR, McMahan MR, Harpold GH. Risk factors for extracranial carotid artery atherosclerosis. Stroke. 1987;18:990 –996.
Damle, D., & Karambelkar, V. (2022). Study of proliferative diabetic retinopathy and its correlation with hypertension, dyslipidaemia and diabetic nephropathy. International Journal of Health Sciences, 6(S1), 8298–8306. https://doi.org/10.53730/ijhs.v6nS1.6930
DeFronzo RA, Ferranini E. Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic vascular disease. Diabetes Care. 1991;14:173–194.
Ferris TF, Gorden P. Effect of angiotensin and norepinephrine upon urate clearance in man.
Hallfrisch J. Metabolic effects of dietary fructose. FASEB J. 1990;4(9):2652–60. doi:10.1096/fasebj.4.9.2189777
Herman JB, Medalie JH, Goldbourt U. Diabetes, prediabetes and uricaemia.Diabetologia.1976;12(1):47–52.
International Diabetes Federation. IDF Diabetic Atlas 7th Edition; 2016.
Johnson RJ, Kang DH, Feig D, Kivlighn S, Kanellis J, Watanabe S, Tuttle KR, Rodriguez- Iturbe B, Herrera-Acosta J, Mazzali M. Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal diseases? Hypertension.2003; 41(6):1183-90.
Kanbay M, Segal M, Afsar B, Kang DH, Rodriguez-Iturbe B, Johnson RJ. The role of uric acid in the pathogenesis of human cardiovascular disease. Heart. 2013; 99(11):759±66. Epub 2013/01/25.
Katsiki N, Papanas N, Fonseca VA, Maltezos E, Mikhailidis DP. Uric acid and diabetes: Is there a link? Current pharmaceutical design, 2013; 19(27): 4930-7.
Keenan T, Zhao W, Rasheed A, Ho WK, Malik R, Felix JF, et al. Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study. Journal of the American College of Cardiology, 2016; 67(4): 407-16.
Kumari MK, Sankaranarayana T. Evaluation of oxidative stress in Type 2 diabetes mellitus patients. IOSR J Dent Med Sci. 2014;13(5):46-50.
Lazzeri C, Valente S, Chiostri M, Sori A, Bernardo P, Gensini GF. Uric acid in the acute phase of ST elevation myocardial infarction submitted to primary PCI: its prognostic role and relation with inflammatory markers: a single center experience. Int J Cardiol 2010; 138: 206-209 [PMID: 18684529]
M. Chonchol, M. G. Shlipak, R. Katz et al., “Relationship of uric acid with progression of kidney disease,” American Journal of Kidney Diseases, vol. 50, no. 2, pp. 239–247, 2007.
Messerli FH, Frohlich ED, Dreslinski GR, Suarez DH, Aristimuno GG. Serum uric acid in essential hypertension: an indicator of renal vascular involvement. Ann Intern Med. 1980;93:817– 821.
Modan M, Halkin H, Karasik A, Lusky A. Elevated serum uric acid: a facet of hyperinsulinemia. Diabetologia. 1987;30:713–718.
R.Klein,B.E.Klein,J.C. Cornoni,J. Maready,J. C.Cassel, and H. A. Tyroler, “Serum uric acid. Its relationship to coronary heart disease risk factors and cardiovascular disease, Evans County, Georgia,” Archives of Internal Medicine, vol. 132, no. 3, pp. 401–410, 1973.
Rao T , Vanukuri NK . A Study on serum uric acid level in type 2 diabetes mellitus and its association with cardiovascular risk factors.Int Arch Integr Med . 2016;3(12):148-55.
Ratnawati, I. G. A. A., Sutapa, G. N., & Ratini, N. N. (2018). The concentration of radon gas in air-conditioned indoor: Air quality can increase the potential of lung cancer. International Journal of Physical Sciences and Engineering, 2(2), 111–119. https://doi.org/10.29332/ijpse.v2n2.169
Srivastava TR, Dixit RK. Role of serum uric acid and nitric oxide in the diagnosis of Type 2 diabetes mellitus-a case control study. Natl J Physiol Pharm Pharmacol. 2017;7(2):170-3.
Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Health and treatment of diabetes mellitus. International Journal of Health Sciences, 5(1), i-v. https://doi.org/10.53730/ijhs.v5n1.2864
T. W. Yoo, K. C. Sung, H. S. Shin et al., “Relationship between serum uric acid concentration and insulin resistance and metabolic syndrome,” Circulation Journal, vol. 69, no. 8, pp. 928–933, 2005.
Vigna GB, Bolzan M, Romagnoni F, Valerio G, Vitale E, Zuliani G, Fellin R. Lipids and other risk factors selected by discriminant analysis in symptomatic patients with supra-aortic and peripheral atherosclerosis. Circulation. 1992;85:2205–2211.
Wang, Ji-Guang, et al. “Prognostic significance of serum creatinine and uric acid in older Chinese patients with isolated systolic hypertension.”Hypertension 37.4 (2001): 1069-1074.
Wu AH, Gladden JD, Ahmed M, Ahmed A, Filippatos G. Relation of serum uric acid to cardiovascular disease. Int J Cardiol. 2016; 213:4±7. Epub 2015/09/06.
Zargari M, Allameh A, Sanati MH, Tiraihi T, Lavasani S, Emadyan O. Relationship between the clinical scoring and demyelination in central nervous system with total antioxidant capacity of plasma during experimental autoimmune encephalomyelitis development in mice. Neurosci Lett.2007;412(1):24-8.
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