Analysis of biochemical and immune biomarker abnormalities associated with severe illness and mortality in COVID -19 disease

Juhi Aggarwal; Jyoti Batra; Sojit Tomo; Rohit Bhagat; Pradhumn Katara

doi:10.53730/ijhs.v6nS1.4980

Analysis of biochemical and immune biomarker abnormalities associated with severe illness and mortality in COVID -19 disease

https://doi.org/10.53730/ijhs.v6nS1.4980

Authors

Juhi Aggarwal Professor & Head, Department of Biochemistry, Santosh Medical College and Hospital, Ghaziabad, Uttar Pradesh, India
Jyoti Batra
dean.research@santosh.ac.in
Professor, Department of Biochemistry, Santosh Medical College and Hospital, Ghaziabad, Uttar Pradesh, India
Sojit Tomo Assistant Professor, Department of Biochemistry, Santosh Medical College and Hospital, Ghaziabad, Uttar Pradesh, India
Rohit Bhagat Assistant Professor, Dept of Internal Medicine, Santosh Deemed to be University, Ghaziabad, Uttar Pradesh, India
Pradhumn Katara Assistant Professor, Biostatistics, Department of Community Medicine, Santosh Deemed to be University, Ghaziabad, Uttar Pradesh, India

Keywords:

abnormalities associated, biochemical, COVID-19, immune biomarker, severe illness

Abstract

Coronavirus Disease 2019 (COVID-19), a new form of respiratory and systemic disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARSCoV2). The inflammation induced by the SARS CoV-2 virus in the host leads to elevation of multiple inflammatory parameters. A raise in PCT, IL-6 and CRP denotes the intensity of inflammation in COVID-19 patients. Similarly, D-DIMER and FIBRINOGEN marks the aberration in the coagulation pathways in COVID-19 patients.COVID-19 positive patients aged between 18 and 65 years were recruited for the study after written informed consent. To confirm all cases according to nucleic acid real time–polymerase chain reaction (RT-PCR) tests. In the present study, a total of 200 COVID-19 patients were assessed. Out of them 100 (50%) were severe cases of COVID-19 and 100 (50%) were non-severe cases of COVID-19. On comparison of various biochemical and immune biomarkers, the severe COVID-19 patients demonstrated significantly higher levels of all biomarkers when compared with non-severe group.

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Published

23-03-2022

How to Cite

Aggarwal, J., Batra, J., Tomo, S., Bhagat, R., & Katara, P. (2022). Analysis of biochemical and immune biomarker abnormalities associated with severe illness and mortality in COVID -19 disease. International Journal of Health Sciences, 6(S1), 2021–2027. https://doi.org/10.53730/ijhs.v6nS1.4980

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Issue

Vol. 6 No. S1 (2022)

Section

Peer Review Articles

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