Role of computed tomography in COVID-19 emergent conditions: A review article

Alaa Saud K Alanazi; Mohammed Ibrahim Suliman Albabtain

doi:10.53730/ijhs.v6nS10.15245

Authors

Alaa Saud K Alanazi KSA, National Guard Health Affairs
Mohammed Ibrahim Suliman Albabtain KSA, National Guard Health Affairs

Keywords:

COVID-19, computed tomography, reverse transcriptase-polymerase chain reaction, pneumonia, diagnostic imaging, healthcare management

Abstract

Background: The COVID-19 pandemic has strained global healthcare systems, highlighting challenges in diagnosing and managing the disease while ensuring patient safety. Aim: This review evaluates the role of computed tomography (CT) in identifying COVID-19-related emergent conditions, emphasizing its diagnostic significance beyond conventional reverse transcriptase-polymerase chain reaction (RT-PCR) testing. Methods: We conducted a comprehensive literature review on CT imaging's effectiveness in detecting pulmonary involvement in COVID-19 patients, comparing its findings with those of RT-PCR and other imaging modalities. Results: CT scans reveal characteristic features of COVID-19 pneumonia, including bilateral ground-glass opacities and consolidations, which can occur even when RT-PCR tests yield negative results. The integration of CT imaging has enhanced early diagnosis and informed clinical decision-making, particularly in emergency settings. Conclusion: CT imaging plays a critical role in managing COVID-19, aiding in the early detection of pulmonary complications and facilitating appropriate patient triage. However, its effectiveness is influenced by pandemic prevalence trends and clinical context, necessitating a multi-faceted diagnostic approach. A standardized strategy incorporating CT imaging alongside RT-PCR testing is essential for improving patient outcomes during pandemic surges.

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References

Li Y, Yao L, Li J, Chen L, Song Y, Cai Z, Yang C (2020) Stability issues of RTPCR testing of SARS-CoV-2 for hospitalized patients clinically diagnosed with COVID-19. J Med Virol 92:903–908 DOI: https://doi.org/10.1002/jmv.25786

Han R, Huang L, Jiang H, Dong J, Peng H, Zhang D (2020) Early clinical and CT manifestations of coronavirus disease 2019 (COVID-19) pneumonia. AJR Am J Roentgenol 215:338–343 DOI: https://doi.org/10.2214/AJR.20.22961

Volpicelli G, Gargani L, Perlini S, Spinelli S, Barbieri G, Lanotte A, Casasola GG, Nogué-Bou R, Lamorte A, Agricola E, Villén T, Deol PS, Nazerian P, Corradi F, Stefanone V, Fraga DN, Navalesi P, Ferre R, Boero E, Martinelli G, Cristoni L, Perani C, Vetrugno L, McDermott C, Miralles-Aguiar F, Secco G, Zattera C, Salinaro F, Grignaschi A, Boccatonda A, Giostra F, Infante MN, Covella M, Ingallina G, Burkert J, Frumento P, Forfori F, Ghiadoni L; on behalf of the International Multicenter Study Group on LUS in COVID-19(2021) Lung ultrasound for the early diagnosis of COVID-19 pneumonia: an international multicenter study. Intensive Care Med 47:444-454 DOI: https://doi.org/10.1007/s00134-021-06373-7

Arevalo-Rodriguez I, Buitrago-Garcia D, Simancas-Racines D, Zambrano-Achig P, Del Campo R, Ciapponi A, Sued O, Martínez-García L, Rutjes A, Low N, Bossuyt PM, Perez-Molina JA, Zamora J (2020) False-negative results of initial RT-PCR assays for COVID-19: a systematic review. https://www.medrx.iv.org/content/10.1101/2020.04.16.20066787v1 DOI: https://doi.org/10.1101/2020.04.16.20066787

Ai T, Yang Z, Hou H, Zhan C, Chen C, Lv W, Tao Q, Sun Z, Xia L (2020) Correlation of chest CT and RT-PCR testing for coronavirus disease 2019 (COVID-19) in China: a report of 1014 cases. Radiology 296:E32–E40 DOI: https://doi.org/10.1148/radiol.2020200642

Scagliotti G, Novello S, Veltri A, Boccuzzi A, Perboni A, Terzolo M (2020) Patients with lung cancer and coronavirus disease 2019 epidemic: an experience from an Italian university hospital. JTO Clin Res Rep 1:100067. https://doi.org/10.1016/j.jtocrr.2020.100067 DOI: https://doi.org/10.1016/j.jtocrr.2020.100067

Simpson S, Kay FU, Abbara S, Bhalla S, Chung JH, Chung M, Henry TS, Kanne JP, Kligerman S, Ko JP, Litt H (2020) Radiological Society of North America expert consensus statement on reporting chest CT findings related to COVID-19. Endorsed by the Society of Thoracic Radiology, the American College of Radiology, and RSNA. J Thorac Imaging 35:219–227 DOI: https://doi.org/10.1097/RTI.0000000000000524

Volpicelli G, Lamorte A, Villén T (2020) What’s new in lung ultrasound during the COVID-19 pandemic. Intensive Care Med 46:1445–1448 DOI: https://doi.org/10.1007/s00134-020-06048-9

Millington SJ, Koenig S, Mayo P, Volpicelli G (2021) Lung ultrasound for patients with coronavirus disease 2019 pulmonary disease. Chest 159:205–211 DOI: https://doi.org/10.1016/j.chest.2020.08.2054

Aguiar M, Van-Dierdonck JB, Mar J, Cusimano N, Knopoff D, Anam V, Stollenwerk N (2021) Critical fluctuations in epidemic models explain COVID-19 post-lockdown dynamics. Sci Rep 11:13839. https://doi.org/10.1038/s41598-021-93366-7. DOI: https://doi.org/10.1038/s41598-021-93366-7

Hope MD, Raptis CA, Henry TS (2020) Chest computed tomography for detection of coronavirus disease 2019 (COVID-19): don’t rush the science. Ann Intern Med 173:147–148 DOI: https://doi.org/10.7326/M20-1382

Raptis CA, Hammer MM, Short RG, Shah A, Bhalla S, Bierhals AJ, Filev PD, Hope MD, Jeudy J, Kligerman SJ, Henry TS (2020) Chest CT and coronavirus disease (COVID-19): a critical review of the literature to date. AJR Am J Roentgenol 215:839–842 DOI: https://doi.org/10.2214/AJR.20.23202

Volpicelli G, Cardinale L, Fraccalini T, Calandri M, Piatti C, Geninatti C, Stranieri G (2021) Descriptive analysis of a comparison between lung ultrasound and chest radiography in patients suspected of COVID-19. Ultrasound J 13:11. https://doi.org/10.1186/s13089-021-00215-9 DOI: https://doi.org/10.1186/s13089-021-00215-9