Management of acute diarrhea in children and nursing care interventions: Review article

https://doi.org/10.53730/ijhs.v4nS1.15384

Authors

  • Hamad Huran F Alanazi KSA, National Guard Health Affairs
  • Ali Mohammed S Alqarni KSA, National Guard Health Affairs
  • Abdullah Abdulqader H Alamri KSA, National Guard Health Affairs
  • Abdulaziz Saad Alghamd KSA, National Guard Health Affairs
  • Salem Faraj M Alqahtani KSA, National Guard Health Affairs
  • Mana Muhammad Abdullah Al-Qahtani KSA, National Guard Health Affairs
  • Salman Ghazi Al-Faridi KSA, National Guard Health Affairs
  • Yazeed Sulaiman S Altawyan KSA, National Guard Health Affairs

Keywords:

Acute diarrhea, children, dehydration, rotavirus, nursing interventions, gastroenteritis, hydration management, infection prevention

Abstract

Background: Acute diarrhea in children is a leading cause of morbidity and mortality, particularly in low- and middle-income countries (LMIC). Despite its relatively low mortality in high-income countries (HIC), it remains a significant cause of hospital visits and healthcare burdens. The disease, often caused by viral, bacterial, or parasitic pathogens, presents differently in LMIC and HIC. Effective management, particularly in children under five, is critical to preventing dehydration and other severe complications. Aim: This review aims to provide an updated synthesis on the etiology, pathogenesis, clinical management, and nursing interventions for acute diarrhea in children. It seeks to compare practices in both LMIC and HIC settings, focusing on dehydration assessment, fluid therapy, and the role of vaccination in prevention. Methods: The review synthesizes recent evidence from clinical studies, guidelines, and expert recommendations on the management of acute diarrhea in children. It includes an analysis of common pathogens, diagnostic methods, dehydration scales, and treatment protocols for both viral and bacterial diarrhea. The focus is on effective interventions, particularly nursing care in the context of hydration management and monitoring. Results: The review highlights that viral infections, especially rotavirus and norovirus, are the predominant causes of diarrhea in children. 

Downloads

Download data is not yet available.

References

Black RE, Morris SS, Bryce J. Where and why are 10 million children dying every year? Lancet. 2003;361(9376):2226–34. DOI: https://doi.org/10.1016/S0140-6736(03)13779-8

Liu L, Oza S, Hogan D, Perin J, Rudan I, Lawn JE, et al. Global, regional, and national causes of child mortality in 2000–13, with projections to inform post-2015 priorities: an updated systematic analysis. Lancet. 2015;385(9966):430–40. DOI: https://doi.org/10.1016/S0140-6736(14)61698-6

Schnadower D, Finkelstein Y, Freedman SB. Ondansetron and probiotics in the management of pediatric acute gastroenteritis in developed countries. Curr Opin Gastroenterol. 2015;31(1):1–6. https://doi.org/10.1097/mog.0000000000000132. DOI: https://doi.org/10.1097/MOG.0000000000000132

World Health Organization, editor. The treatment of diarrhoea: a manual for physicians and other senior health workers. In: World Health Organization. Geneva; 2005.

American Academy of Pediatrics A. Practice parameter: the management of acute gastroenteritis in young children. Pediatrics. 1996;97(3):424–35.

Guerrant RL, Hughes JM, Lima NL, Crane J. Diarrhea in developed and developing countries: magnitude, special settings, and etiologies. Rev Infect Dis. 1990;12(Supplement 1):S41–50. https://doi.org/10.1093/clinids/12.Supplement_1.S41. DOI: https://doi.org/10.1093/clinids/12.Supplement_1.S41

Giannattasio A, Guarino A, Lo VA. Management of children with prolonged diarrhea. F1000Res. 2016;5:F1000 Faculty Rev-206. https://doi.org/10.12688/f1000research.7469.1. DOI: https://doi.org/10.12688/f1000research.7469.1

Bányai K, Estes MK, Martella V, Parashar UD. Viral gastroenteritis. Lancet. 2018;392(10142):175–86. DOI: https://doi.org/10.1016/S0140-6736(18)31128-0

Cherry JD, Harrison GJ, Kaplan SL, Hotez PJ, Steinbach WJ. Feigin and Cherry’s textbook of pediatric infectious diseases: Elsevier; 2018.

Operario DJ, Platts-Mills JA, Nadan S, Page N, Seheri M, Mphahlele J, et al. Etiology of severe acute watery diarrhea in children in the global rotavirus surveillance network using quantitative polymerase chain reaction. J Infect Dis. 2017;216(2):220–7. DOI: https://doi.org/10.1093/infdis/jix294

Kim J, Smathers SA, Prasad P, Leckerman KH, Coffin S, Zaoutis T. Epidemiological features of Clostridium difficile-associated disease among inpatients at children’s hospitals in the United States, 2001–2006. Pediatrics. 2008;122(6):1266–70. https://doi.org/10.1542/peds.2008-0469. DOI: https://doi.org/10.1542/peds.2008-0469

Akhi MT, Seifi SJ, Asgharzadeh M, Rezaee MA, Oskuei SA, Pirzadeh T, et al. Role of enterotoxigenic Bacteroides fragilis in children less than 5 years of age with diarrhea in Tabriz, Iran. Jundishapur J Microbiol. 2016;9(6):e32163. DOI: https://doi.org/10.5812/jjm.32163

Ramamurthy D, Pazhani GP, Sarkar A, Nandy RK, Rajendran K, Sur D, et al. Case-control study on the role of enterotoxigenic Bacteroides fragilis as a cause of diarrhea among children in Kolkata. India PloS One. 2013;8(4):e60622. https://doi.org/10.1371/journal.pone.0060622. DOI: https://doi.org/10.1371/journal.pone.0060622

Riera-Montes M, O’ryan M, Verstraeten T. Norovirus and rotavirus disease severity in children: systematic review and meta-analysis. Pediatr Infect Dis J. 2018;37(6):501–5. DOI: https://doi.org/10.1097/INF.0000000000001824

Das JK, Duggan C, Bhutta ZA. Persistent diarrhea in children in developing countries. In: Textbook of pediatric gastroenterology, hepatology and nutrition: Springer; 2016. p. 195–202. DOI: https://doi.org/10.1007/978-3-319-17169-2_17

Riera-Montes M, Cattaert T, Verstraeten T. Rotavirus vaccination may reduce acute gastroenteritis rates across all age groups in England. Value Health. 2017;20(9):A780. DOI: https://doi.org/10.1016/j.jval.2017.08.2261

Aliabadi N, Antoni S, Mwenda JM, Weldegebriel G, Biey JN, Cheikh D, et al. Global impact of rotavirus vaccine introduction on rotavirus hospitalisations among children under 5 years of age, 2008–16: findings from the Global Rotavirus Surveillance Network. Lancet Glob Health. 2019;7(7):e893–903. DOI: https://doi.org/10.1016/S2214-109X(19)30207-4

Hassan E, Baldridge MT. Norovirus encounters in the gut: multifaceted interactions and disease outcomes. Mucosal Immunol. 2019:1–9. DOI: https://doi.org/10.1038/s41385-019-0199-4

Kliegman R, Stanton B, St. Geme JW, Schor NF, Behrman RE, Nelson WE. Nelson textbook of pediatrics. 2018.

Long SS, Brady MT, Jackson MA, Kimberlin DW. Red book 2018: report of the committee on infectious diseases: American Academy of Pediatrics; 2018.

Thiagarajah JR, Donowitz M, Verkman AS. Secretory diarrhoea: mechanisms and emerging therapies. Nat Rev Gastroenterol Hepatol. 2015;12(8):446–57. DOI: https://doi.org/10.1038/nrgastro.2015.111

Bresee JS, Duggan C, Glass RI, King CK. Managing acute gastroenteritis among children; oral rehydration, maintenance, and nutritional therapy. 2003.

Shane AL, Mody RK, Crump JA, Tarr PI, Steiner TS, Kotloff K et al. 2017 Infectious Diseases Society of America clinical practice guidelines for the diagnosis and management of infectious diarrhea. Clin Infect Dis 2017;65(12):e45-e80. DOI: https://doi.org/10.1093/cid/cix669

Guarino A, Ashkenazi S, Gendrel D, Vecchio AL, Shamir R, Szajewska H. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition/European Society for Pediatric Infectious Diseases evidence-based guidelines for the management of acute gastroenteritis in children in Europe: update 2014. J Pediatr Gastroenterol Nutr. 2014;59(1):132–52. DOI: https://doi.org/10.1097/MPG.0000000000000375

Centers for Disease Control and Prevention. Managing acute gastroenteritis among children: oral rehydration, maintenance, and nutritional therapy. Pediatrics. 2004;114(2):507. DOI: https://doi.org/10.1542/peds.114.2.507

Steiner MJ, DeWalt DA, Byerley JS. Is this child dehydrated? Jama. 2004;291(22):2746–54. DOI: https://doi.org/10.1001/jama.291.22.2746

Friedman JN, Goldman RD, Srivastava R, Parkin PC. Development of a clinical dehydration scale for use in children between 1 and 36 months of age. J Pediatr. 2004;145(2):201–7. https://doi.org/10.1016/j.jpeds.2004.05.035. DOI: https://doi.org/10.1016/j.jpeds.2004.05.035

Gorelick MH, Shaw KN, Murphy KO. Validity and reliability of clinical signs in the diagnosis of dehydration in children. Pediatrics. 1997;99(5):e6-e. DOI: https://doi.org/10.1542/peds.99.5.e6

Freedman SB, Vandermeer B, Milne A, Hartling L, Johnson D, Black K, et al. Diagnosing clinically significant dehydration in children with acute gastroenteritis using noninvasive methods: a meta-analysis. J Pediatr. 2015;166(4):908–16 e6. DOI: https://doi.org/10.1016/j.jpeds.2014.12.029

Falszewska A, Szajewska H, Dziechciarz P. Diagnostic accuracy of three clinical dehydration scales: a systematic review. Arch Dis Child. 2018;103(4):383–8. https://doi.org/10.1136/archdischild-2017-313762. DOI: https://doi.org/10.1136/archdischild-2017-313762

Pruvost I, Dubos F, Aurel M, Hue V, Martinot A. Valeur des données anamnestiques, cliniques et biologiques pour le diagnostic de déshydratation par diarrhée aiguë chez l’enfant de moins de 5 ans. Presse Med. 2008;37(4):600–9. DOI: https://doi.org/10.1016/j.lpm.2007.10.014

Lynch SV, Ng SC, Shanahan F, Tilg H. Translating the gut microbiome: ready for the clinic? Nat Rev Gastroenterol Hepatol. 2019:1–6. DOI: https://doi.org/10.1038/s41575-019-0204-0

Churgay CA, Aftab Z. Gastroenteritis in children: Part II. Prevention and management. Am Fam Physician. 2012;85(11):1066–70.

Lo Vecchio A, Vandenplas Y, Benninga M, Broekaert I, Falconer J, Gottrand F, et al. An international consensus report on a new algorithm for the management of infant diarrhoea. Acta Paediatr. 2016;105(8):e384–e9. DOI: https://doi.org/10.1111/apa.13432

Women's NCCf, Health Cs. Diarrhoea and vomiting caused by gastroenteritis: diagnosis, assessment and management in children younger than 5 years. 2009.

Binnicker MJ. Multiplex molecular panels for diagnosis of gastrointestinal infection: performance, result interpretation, and cost-effectiveness. J Clin Microbiol. 2015;53(12):3723–8. DOI: https://doi.org/10.1128/JCM.02103-15

Pernica JM, Steenhoff AP, Mokomane M, Moorad B, Lechiile K, Smieja M, et al. Rapid enteric testing to permit targeted antimicrobial therapy, with and without Lactobacillus reuteri probiotics, for paediatric acute diarrhoeal disease in Botswana: a pilot, randomized, factorial, controlled trial. PLoS One. 2017;12(10):e0185177. https://doi.org/10.1371/journal.pone.0185177. DOI: https://doi.org/10.1371/journal.pone.0185177

McDonald LC, Gerding DN, Johnson S, Bakken JS, Carroll KC, Coffin SE, et al. Clinical practice guidelines for Clostridium difficile infection in adults and children: 2017 update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). Clin Infect Dis. 2018;66(7):e1–e48. DOI: https://doi.org/10.1093/cid/cix1085

Hartling L, Bellemare S, Wiebe N, Russell KF, Klassen TP, Craig WR. Oral versus intravenous rehydration for treating dehydration due to gastroenteritis in children. Cochrane Database Syst Rev. 2006;3. DOI: https://doi.org/10.1002/14651858.CD004390.pub2

Bellemare S, Hartling L, Wiebe N, Russell K, Craig WR, McConnell D, et al. Oral rehydration versus intravenous therapy for treating dehydration due to gastroenteritis in children: a meta-analysis of randomised controlled trials. BMC Med. 2004;2(1):11. DOI: https://doi.org/10.1186/1741-7015-2-11

Fonseca BK, Holdgate A, Craig JC. Enteral vs intravenous rehydration therapy for children with gastroenteritis: a meta-analysis of randomized controlled trials. Arch Pediatr Adolesc Med. 2004;158(5):483–90. DOI: https://doi.org/10.1001/archpedi.158.5.483

Mejía A, Atehortua SC, Sierra JM, Mejía ME, Ramírez C, Florez ID. Costs of oral and nasogastric rehydration compared to intravenous rehydration in children under 5 years of age with diarrhea in Colombia. Rev Salud Publica (Bogota). 2017;19(1):17–23. DOI: https://doi.org/10.15446/rsap.v19n1.49759

Pershad J. A systematic data review of the cost of rehydration therapy. Appl Health Econ Health Policy. 2010;8(3):203–14. https://doi.org/10.2165/11534500-000000000-00000. DOI: https://doi.org/10.2165/11534500-000000000-00000

Moher D, Liberati A, Tetzlaff J, Altman DG, Group P. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6(7):e1000097. DOI: https://doi.org/10.1371/journal.pmed.1000097

Hahn S, Kim Y, Garner P. Reduced osmolarity oral rehydration solution for treating dehydration caused by acute diarrhoea in children. Cochrane Database Syst Rev. 2002;1:CD002847. https://doi.org/10.1002/14651858.CD002847. DOI: https://doi.org/10.1002/14651858.CD002847

Gregorio GV, Gonzales MLM, Dans LF, Martinez EG. Polymer-based oral rehydration solution for treating acute watery diarrhoea. Cochrane Database Syst Rev. 2016;12:CD006519. https://doi.org/10.1002/14651858.CD006519.pub3. DOI: https://doi.org/10.1002/14651858.CD006519.pub3

Freedman SB, Willan AR, Boutis K, Schuh S. Effect of dilute apple juice and preferred fluids vs electrolyte maintenance solution on treatment failure among children with mild gastroenteritis: a randomized clinical trial. JAMA. 2016;315(18):1966–74. https://doi.org/10.1001/jama.2016.5352. DOI: https://doi.org/10.1001/jama.2016.5352

American Academy of Pediatrics. Practice parameter: the management of acute gastroenteritis in young children. American Academy of Pediatrics. Provisional Committee on Quality Improvement, Subcommittee on Acute Gastroenteritis. Pediatrics. 1996;97(3):424–35. DOI: https://doi.org/10.1542/peds.97.3.424

Florez ID. Balanced solutions vs. 0.9% saline for children with acute diarrhoea and severe dehydration [title]. In: Cochrane Infectious Diseases Group. 2019. https://www.cochrane.org/title/balanced-solutions-vs-09-saline-children-acute-diarrhoea-and-severe-dehydration. DOI: https://doi.org/10.1002/14651858.CD013640

Antequera Martín AM, Barea Mendoza JA, Muriel A, Sáez I, Chico-Fernández M, Estrada-Lorenzo JM, et al. Buffered solutions versus 0.9% saline for resuscitation in critically ill adults and children. Cochrane Database Syst Rev. 2019;(7). https://doi.org/10.1002/14651858.CD012247.pub2. DOI: https://doi.org/10.1002/14651858.CD012247.pub2

Toaimah FHS, Mohammad HMF. Rapid intravenous rehydration therapy in children with acute gastroenteritis: a systematic review. Pediatr Emerg Care. 2016;32(2):131–5. DOI: https://doi.org/10.1097/PEC.0000000000000708

Iro M, Sell T, Brown N, Maitland K. Rapid intravenous rehydration of children with acute gastroenteritis and dehydration: a systematic review and meta-analysis. BMC Pediatr. 2018;18(1):44. DOI: https://doi.org/10.1186/s12887-018-1006-1

Allen CH, Etzwiler LS, Miller MK, Maher G, Mace S, Hostetler MA, et al. Recombinant human hyaluronidase-enabled subcutaneous pediatric rehydration. Pediatrics. 2009;124(5):e858–e67. DOI: https://doi.org/10.1542/peds.2008-3588

Zubairi H, Nelson BD, Tulshian P, Fredricks K, Altawil Z, Mireles S, et al. Hyaluronidase-assisted resuscitation in Kenya for severely dehydrated children. Pediatr Emerg Care. 2019;35(10):692–5. DOI: https://doi.org/10.1097/PEC.0000000000001183

Spandorfer PR. Subcutaneous rehydration: updating a traditional technique. Pediatr Emerg Care. 2011;27(3):230–6. DOI: https://doi.org/10.1097/PEC.0b013e31820e1405

Saganski GF, de Souza Freire MH. Safety and effectiveness of hypodermoclysis compared to intravenous fluid infusion for rehydrating children with mild to moderate dehydration: a systematic review protocol. JBI Database System Rev Implement Rep. 2019;17(7):1270–6. DOI: https://doi.org/10.11124/JBISRIR-2017-003696

Gregorio GV, Dans LF, Silvestre MA. Early versus delayed refeeding for children with acute diarrhoea. Cochrane Database Syst Rev. 2011;7. DOI: https://doi.org/10.1002/14651858.CD007296.pub2

Gaffey MF, Wazny K, Bassani DG, Bhutta ZA. Dietary management of childhood diarrhea in low-and middle-income countries: a systematic review. BMC Public Health. 2013;13(S3):S17. DOI: https://doi.org/10.1186/1471-2458-13-S3-S17

MacGillivray S, Fahey T, McGuire W. Lactose avoidance for young children with acute diarrhoea. Cochrane Database Syst Rev. 2013;10. DOI: https://doi.org/10.1002/14651858.CD005433.pub2

Florez ID, Veroniki A-A, Al Khalifah R, Yepes-Nuñez JJ, Sierra JM, Vernooij RW, et al. Comparative effectiveness and safety of interventions for acute diarrhea and gastroenteritis in children: a systematic review and network meta-analysis. PLoS One. 2018;13(12):e0207701. DOI: https://doi.org/10.1371/journal.pone.0207701

Cremon C, Barbaro MR, Ventura M, Barbara G. Pre- and probiotic overview. Curr Opin Pharmacol. 2018;43:87–92. https://doi.org/10.1016/j.coph.2018.08.010. DOI: https://doi.org/10.1016/j.coph.2018.08.010

Allen SJ, Martinez EG, Gregorio GV, Dans LF. Probiotics for treating acute infectious diarrhoea. Cochrane Database Syst Rev. 2010;11. DOI: https://doi.org/10.1002/14651858.CD003048.pub3

Feizizadeh S, Salehi-Abargouei A, Akbari V. Efficacy and safety of Saccharomyces boulardii for acute diarrhea. Pediatrics. 2014;134(1):e176–e91. DOI: https://doi.org/10.1542/peds.2013-3950

Dinleyici EC, Eren M, Ozen M, Yargic ZA, Vandenplas Y. Effectiveness and safety of Saccharomyces boulardii for acute infectious diarrhea. Expert Opin Biol Ther. 2012;12(4):395–410. https://doi.org/10.1517/14712598.2012.664129. DOI: https://doi.org/10.1517/14712598.2012.664129

Urbańska M, Gieruszczak-Białek D, Szajewska H. Systematic review with meta-analysis: Lactobacillus reuteri DSM 17938 for diarrhoeal diseases in children. Aliment Pharmacol Ther. 2016;43(10):1025–34. DOI: https://doi.org/10.1111/apt.13590

Published

15-01-2020

How to Cite

Alanazi, H. H. F., Alqarni, A. M. S., Alamri, A. A. H., Alghamd, A. S., Alqahtani, S. F. M., Al-Qahtani, M. M. A., Al-Faridi, S. G., & Altawyan, Y. S. S. (2020). Management of acute diarrhea in children and nursing care interventions: Review article. International Journal of Health Sciences, 4(S1), 442–457. https://doi.org/10.53730/ijhs.v4nS1.15384

Issue

Section

Peer Review Articles

Most read articles by the same author(s)

1 2 > >>