Formulation and evaluation of econazole nitrate microemulsion
Keywords:
econazole nitrate, microemulsion, antifungalAbstract
Econazole Nitrate microemulsion is presently considered as the novel drug delivery system. It shows prolonged action. It is considered as the imidazole antifungal agent which shows broad spectrum activity. Antifungal agent contains the lipophilic groups which are administered in the microemulsions as they are able to penetrate the system easily. It belongs to BCS Class II drug. i.e., low soluble and highly permeable. The drug efficacy of topical formulation is limited to instability due to poor solubility and low permeability. These are the basic reasons which increase the scope for designing of microemulsion. The topical microemulsion containing Econazole Nitrate prepared using oleic acid as the oil phase, tween 20 as surfactant and propylene glycol as co- surfactant. The optimized formulation B1 was evaluated for various tests such as Particle size, Zeta potential, pH, Viscosity, Scanning electron microscopy and Electrical conductivity.
Downloads
References
Hoar TP, Schulman JH. Transparent water-in-oil dispersions, the oleopathichydromicelle. Nature 1943;152:102-3.
J. H. Schulman et al. Mechanism of formation and structure of micro emulsions by electron microscopy. The Journal of Physical Chemistry 1959; 63: 1677–1680.
Kaur J, Kaur J, Jaiswal S, Gupta GD. Recent advances in topical drug delivery system. Pharm Res., 2016; 6(07): 6353-59.
Joshi B et al; “Emulgel: A Comprehensive Review on the Recent Advances in Topical Drug Delivery.” International Research Journal of Pharmacy. 2011, 2(11), 66-70.
Patel Rahul R., Kanu R Patel, Mukesh R Patel. Formulation and Characterization of Microemulsion based Gel of Antifungal Drug. – Review.
Kumar. K. Senthil et al. Microemulsions as Carrier for Novel Drug Delivery: A Review. International Journal of Pharmaceutical Sciences Review and Research 2011; 10: 37-45.
Gurjot Kaur, Bedi PMS and Jasjeet K Narang. Topical Nanoemulgel: A Novel Pathway for Investigating Alopecia. Journal of Nanomedicine & Nanotechnology. 2017; 8( 6): 1-5
Gajra B, Pandya, Singh S and Rabari: Mucoadhesive hydrogel films of econazole nitrate formulation and optimization using factorial design. Journal of Drug Delivery 2014: 1-14.
Gupta PC, Kapoor A and Pandey P: Designing and characterization of econazole nitrate nanostructured lipid carriers gel for topical delivery. European Journal of Pharmaceutical and Medical Research 2018; 5(6): 559-67.
Shaikh NM and Kulkarni KB: Formulation and evaluation of nanoemulsion for topical application. Journal of Drug Delivery and Therapeutics 2019; 9(4): 370-75
Patel H C, Parmar G, Seth A K, Patel J D and Patel S R, “Formulation and evaluation of o/w nanoemulsion of ketoconazole”, International Journal of Pharmaceutical Sciences, 2013, 4(4): 338-351.
M Joyce Nirmala, N Chandrasekaran, Amitava Mukherjee. Enhanced solubilization of aqueous insoluble anti-hypertensive drug. Int J Pharm Pharm Sci 2012;4:366-8.
Zhai G., Zhu W., Guo C., Yu A., Gao Y., Microemulsion-based hydrogel formulation of penciclovir for topical delivery, International journal of pharmaceutics, 2009, 378, 152- 158
Chena H, Changa X, Dub D, Jin L, “Microemulsion-Based Hydrogel Formulation of Ibuprofen for Topical Delivery”, International Journal of Pharmaceutics; 2006, 52–58.
Patel MR, Patel RB, Parikh JR, and Patel BG, "Effect of Formulation Components on the In vitro Permeation of MicroemulsionDrug Delivery System of Fluconazole”, American Association of Pharmaceutical Scientists; Vol. 10 (3): 2009, 917-923
Gui S., Pan E., Liu P., Lu c, Development of Novel Microemulsion-based Hydrogel for Topical Delivery of Sinomenium, Latin American journal of pharmacy, 2011,30(5), 931- 936.
Vishal Yadav, Prakash Jadhav, Shailaja Dombe, Anjali Bodhe, Pranali Salunkhe. Formulation and evaluation of microsponge gel for topical delivery of the antifungal drug. Int J Appl Pharm 2017;9:30-7
Moghimipour E, Salimi A, “Design and Characterization of Microemulsion Systems for Naproxen”, Advanced Pharmaceutical Bulletin; Vol 3(1): 2013, 63-71.
Thansungnoen T, Daduang J and Priprem A: Formulation and evaluation of niosomes encapsulated with KT2 and RT2: antimicrobial and anticancer peptides derived from crocodile leukocyte extract. International Journal of Pharmaceutical Science and Research 2020: 11(2); 623-30.
Karthik. T.V.K., Martinez, V., Agrawal. V., Porous silicon ZnO/SnO2 structures for CO2 detection, Journal of alloys and Compounds , 731, 2008, 853-863
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.
