Formulation and evaluation of microemulsion containing ketoprofen
Keywords:
ketoprofen, microemulsion, particle size, zeta potential, scanning electron microscopyAbstract
Ketoprofen microemulsion is presently considered as the novel drug delivery system. It shows prolonged action. Ketoprofen is a BCS II class drug. It is a highly lipophilic poorly soluble drug with low oral bioavailability. The present aim was to increase the solubility by a microemulsion system for topical delivery. Microemulsions are clear, stable and isotropic liquid. They show advantages such as spontaneous preparation, scale up, ease of preparation, improving drug solubility of hydrophobic drugs. It is also used to increase the bioavailability of drug. These also aim at controlling the bioavailability of various drug molecules. The review put forward the development in a microemulsion-containing system. They improve solubility, chemical stability and oral bioavailability of poorly water-soluble drugs. There is a formulation of four different batches. The batches differ in the quantity of surfactant and co-surfactants.
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References
T.P. Hoar and J.H. Schulman. Transparent water-in-oil dispersions, the oleopathic hydro micelle. Nature 1943; 152: 102–103
J. H. Schulman et al. Mechanism of formationand structure of micro emulsions by electronmicroscopy. The Journal of Physical Chemistry1959; 63: 1677–1680.
Danielsson and B. Lindman. The definition of amicroemulsion, Colloids and Surfaces 1981; 3:391–392.
Shinoda K and Lindman B. Organised surfactantsystems: Microemulsions. Langmuir 1987; 3:135–149.
M. Jayne Lawrencea and Gareth D. Reesb.Microemulsion-based media as novel drugdelivery systems. Advanced Drug DeliveryReviews 2000; 45: 89–121.
Kumar. K. Senthil et al. Microemulsions asCarrier for Novel Drug Delivery: A Review.International Journal of PharmaceuticalSciences Review and Research 2011; 10: 37-45.
Patel R. Mrunali. Microemulsions: As NovelDrug Delivery Vehicle. 2007; 5.
Madhav. S and Gupta. D. A review onmicroemulsion based system. InternationalJournal of Pharmaceutical Sciences andResearch 2011; 2 (8): 1888.
Ghosh, P.K. and Murthy R.S.R. Microemulsions:A Potential Drug Delivery System. Current DrugDelivery 2006; 3: 167-180.
Lacy CF, Armstrong, LL, Ingrim NB, Lance LL; Drug Information Handbook, sixth ed. Lexi-Comp Inc., Cleveland, 1998.
16. Yim DS, Jang IJ, Shin SG, Yoo JH, Eun HC; Pharmacokinetic and skin irritation of transdermal ketoprofen. Kor. J. Clin. Pharmacol. Ther. 1994, 2:21–27.
Valenta C, Almasi-Szabo I; In vitro diffusion studies of ketoprofen transdermal therapeutic systems. Drug Dev. Ind. Pharm. 1995, 21:1799–1805.
Patil P, Joshi P; Effect of formulation variable on preparation and evaluation of gelled self-emulsifying drug delivery system of ketoprofen, AAPS Pharm. Sci. Tech. 2004, 5, 3:42
Yun– Seok Rhee, Jung-Gyo Choi; Transdermal delivery of ketoprofen using microemulsions. Int. J. Pharm. 2001, 228:61-170.
Podlogar F, Beˇster M, Gaˇsperlin M; The effect of internal structure of selected water-Tween 40®-Imwitor 308®-IPM microemulsions on ketoprofene release. Int. J Pharm. 2005, 302:68–77
Rhee GJ, Woo JS, Hwang SJ, Lee YW, Lee CH; Topical oleo-hydrogel preparation of ketoprofen with enhanced skin permeability. Drug Dev. Ind. Pharm. 1999, 25:717–726
Valenta C, Wanka M, Heidlas J; Evaluation of novel soya-lecithin formulation for dermal use containing ketoprofen as a model drug. J. Control. Release. 2000, 63:165– 173.
Panus PC, Campbell J, Kulkarni SB, Herrick RT, Ravis WR, Banga AK; Transdermal iontophoretic delivery of ketoprofen through human cadaver skin and in humans. J. Control. Release. 1997, 44:113–121.
Tashiro, Y., Kato, Y., Hayakawa, E., Ito, K., 2000. Iontophoretic transdermal delivery of ketoprofen: Novel method for the evaluation of plasma drug concentration in cutaneous vein. Biol. Pharm. Bull. 23, 632–636.
Obata Y, Sato H, Li CJ, Takayama K, Higashiyama K, Nagai T, Isowa K; Effect of synthesized cyclo-hexanol derivatives using L-menthol as a lead compound on the percutaneous absorption of ketoprofen. Int. J. Pharm. 2000, 198:191–200.
Widana, I.K., Sumetri, N.W., Sutapa, I.K., Suryasa, W. (2021). Anthropometric measures for better cardiovascular and musculoskeletal health. Computer Applications in Engineering Education, 29(3), 550–561. https://doi.org/10.1002/cae.2220
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