Formulation and evaluation of topical gel containing combination of dapsone and acetazolamide
Keywords:
topical drug delivery system (TDDS), gel formulation, angioedema, HPMC, dapsone, acetazolamide, Antibiotic prophylaxis habits, diureticAbstract
The idea of innovation is to formulate a gel containing the combination of Dapsone and Acetazolamide for the treatment of Angioedema. Dapsone being a sulfone has antibacterial and antibiotic properties whereas Acetazolamide has a Diuretic property. So, a combination of these drugs helps to obtain a formulation with antibacterial, antibiotic and diuretic effect for the treatment of Angioedema. Various excipients such as a gelling agent, preservative, solubilizing agent etc. are used to form a stable and flawless gel formulation. The gel formulation prepared is used in the treatment of Angioedema that is a rapid oedema or swelling at specific areas such as face, genitals, hands, feet’s etc. The formulation has a comparatively greater effect for treatment of angioedema. Marketed formulations in treatment of angioedema have a specific action on the body such as antibiotic or diuretic whereas this new formulated gel has a combination of drugs that have a dual effect for the treatment of Angioedema. The swelling caused by the disease and the spread of infection is more effectively treated by this combination used in the gel formulation.
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References
Gupta, S. and Pandit, K.R., In; Concepts of Pharmaceutical Dosage Form, 9th Edition, B.S. Shah Publication, Delhi, 1997, pg.no.155-156.
Tripathi, K.D., In; Essentials of Medical Pharmacology, 5th Edition, Jaypee Brothers Medical Publisher Pvt. Ltd, New Delhi,2004, pg no.8-16.
Ahuja, M., Bodake, S.H., Gupta, S. and Jayal, V., In; Piyush Synopsis for Pharmacy,2nd Edition., Piyush Book Publication Pvt. Ltd., 2005, pg no.443.
Brahmankar, D.M. and Jaiswal, S.B., In; Biopharmaceutics and Pharmacokinetic, A Treatise,1st Edition, Vallabh Prakashan, Delhi,1995, pg no.7-8.
Kumar B,Antimicrobial resistance in leprosy.Clinical microbiology and infection: the official publication of the European Society of Clinical Microbiology and Infectious Diseases.2018 Dec 21.
Kassamali R, Sica DA.Acetazolamide: aforgotten diuretic agent. Cardiol Rev.2011 Nov-Dev;19(6):276-8.
Mikami R, Mishra B, Rajnikant P S, Balasubramaniam J. Development and evaluation of a novel floating in situ gelling system of amoxicillin for eradication of Helicobacter pylori. International Journal of Pharmaceutics, 335(1): 114-122,2007.
Bakhle S. S., Upadhye K.P.,Dixit G.R., Wadetwar R.N. Solubility and Dissolution Improvement of Poorly Soluble Drug Using Solid Dispersion Technique. International Journal of Pharmacy and Technology. 2 (4); 1230-1240;2010.
Skoog, Douglas A; Holler, F. James; Crouch, Stanley R. (2007). Principles of Instrumental Analysis (6th edition). Belmont, CA: Thomson Brooks/Cole.
Tamm, L.K. and Tatulian, S.A. Infrared spectroscopy of proteins and peptides in lipid bilayers.pg no. 365-429.
Seshadri, S., Khurana,R. and Fink,A.L. Fourier transform infrared spectroscopy in analysisof protein deposits.Methods Enzymol.pg no. 559-576.
Barth, A. Infrared spectroscopy of proteins. Biochim Biophys Acta 1767, 1073-1105 (2007)
Doglia, S.M., Ami, D., Natalello, A., Gatti-Lafranconi, P. and Lotti, M. Fourier transform infrared spectroscopy analysis of the conformational quality of recombinant proteins within inclusion bodies.
Privalov PL, Potekhin SA. Scanning microcalorimetry in studying temperature induced changes in proteins.
Hohne G, Hemminger W, Flammersheim H-J. Differential Scanning Calorimetry: An introduction for practitioners.
Haines PJ, Reading M, Wilburn FW. Differential thermal analysis and differential scanning calorimetry. In Brown ME. (ed); Handbook of Thermal Analysis and Calorimetry, vol I.
Kumar A,Dixit CK (2017). “Methods for characterization of nanoparticles”. Advances inNanomedicine for the Delivery of Therapeutic Nucleic Acids.pg no. 43-58.
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