A review on memory enhancing activity of ginger
Keywords:
Zingiber officinale, Alzheimer’s disease, Degenerative disease, Dementia, NeuroprotectiveAbstract
Age-related ailments are on the rise as people live longer. Worldwide, there is an increasing need for dementia drugs, however the current medications do not meet those needs. Natural compounds, used in ancient medicine for their advantages and tolerance, have recently attracted scientific study. This analysis examines ginger's anti- and anti-vascular dementia (Zingiber officinale) properties, two of the most common and devastating dementias. Clinical trials on Alzheimer's and Vascular Dementia models have indicated therapeutic advantages from ginger compounds. This research reveals that ginger's components may help treat and prevent the disease. Alzheimer's disease is a neurological disorder that primarily affects the elderly and causes cognitive failure. Various cellular problems such as amyloid-beta buildup, hyperphosphorylation of tau protein, neurotransmitter imbalance, apoptosis, oxidative stress, and inflammatory reactions cause this disease. New Alzheimer's medicines should be able to tackle additional ailments, such as side effects and pharmacokinetic difficulties. Phytochemicals are powerful anti-disease agents that are widely used in humans. In vitro trials are included after eligibility screening. The most frequent interventive processes are oxidative stress and apoptosis. A recent study links Alzheimer's pathology with signalling pathways. In vivo studies and clinical trials assist clarify cognitive test results.
Downloads
References
De Lima, R.M.T.; Dos Reis, A.C.; de Menezes, A.P.M.; Santos, J.V.O.; Filho, J.; Ferreira, J.R.O.; de Alencar, M.; da Mata, A.; Khan, I.N.; Islam, A.; et al. Protective and therapeutic potential of ginger (Zingiber officinale) extract and [6]-gingerol in cancer: A comprehensive review. Phytother. Res. 2018, 32, 1885–1907.
Nagendra chari, K.L.; Manasa, D.; Srinivas, P.; Sowbhagya, H.B. Enzyme-assisted extraction of bioactive compounds from ginger (Zingiber officinale Roscoe). Food Chem. 2013, 139, 509–514.
Choi, J.G.; Kim, S.Y.; Jeong, M.; Oh, M.S. Pharmacotherapeutic potential of ginger and its compounds in age-related neurological disorders. Pharmacol. Ther. 2018, 182, 56–69.
Pagano, E.; Souto, E.B.; Durazzo, A.; Sharifi-Rad, J.; Lucarini, M.; Souto, S.B.; Salehi, B.; Zam, W.; Montanaro, V.; Lucariello, G.; et al. Ginger (Zingiber officinale Roscoe) as a nutraceutical: Focus on the metabolic, analgesic, and antiinflammatory effects. Phytother. Res. 2020, 35, 2403–2417.
Mohd Yusof, Y.A. Gingerol and Its Role in Chronic Diseases. Adv. Exp. Med. Biol. 2016, 929, 177–207.
Jung, M.Y.; Lee, M.K.; Park, H.J.; Oh, E.B.; Shin, J.Y.; Park, J.S.; Jung, S.Y.; Oh, J.H.; Choi, D.S. Heat-induced conversion of gingerols to shogaols in ginger as affected by heat type (dry or moist heat), sample type (fresh or dried), temperature and time. Food Sci. Biotechnol. 2018, 27, 687–693.
Kumar N.V., Murthy P.S., Manjunatha J.R., Bettadaiah B.K. Synthesis and quorum sensing inhibitory activity of key phenolic compounds of ginger and their derivatives. Food Chem. 2014;159:451–457.
Citronberg J., Bostick R., Ahearn T., Turgeon D.K., Ruffin M.T., Djuric Z., Sen A., Brenner D.E., Zick S.M. Effects of ginger supplementation on cell-cycle biomarkers in the normal-appearing colonic mucosa of patients at increased risk for colorectal cancer: Results from a pilot, randomized, and controlled trial. Cancer Prev. Res. 2013;6:271–281.
Ho S., Chang K., Lin C. Anti-neuroinflammatory capacity of fresh ginger is attributed mainly to 10-gingerol. Food Chem. 2013;141:3183–3191.
Akinyemi A.J., Thome G.R., Morsch V.M., Stefanello N., Goularte J.F., Bello-Klein A., Oboh G., Chitolina Schetinger M.R. Effect of dietary supplementation of ginger and turmeric rhizomes on angiotensin-1 converting enzyme (ACE) and arginase activities in L-NAME induced hypertensive rats. J. Funct. Foods. 2015;17:792–801.
Suk S., Kwon G.T., Lee E., Jang W.J., Yang H., Kim J.H., Thimmegowda N.R., Chung M., Kwon J.Y., Yang S., et al. Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice. Mol. Nutr. Food Res. 2017;61:1700139.
Walstab J., Krueger D., Stark T., Hofmann T., Demir I.E., Ceyhan G.O., Feistel B., Schemann M., Niesler B. Ginger and its pungent constituents non-competitively inhibit activation of human recombinant and native 5-HT3 receptors of enteric neurons. Neurogastroent. Motil. 2013;25:439–447.
Townsend E.A., Siviski M.E., Zhang Y., Xu C., Hoonjan B., Emala C.W. Effects of ginger and its constituents on airway smooth muscle relaxation and calcium regulation. Am. J. Resp. Cell Mol. 2013;48:157–163.
Prasad S., Tyagi A.K. Ginger and its constituents: role in prevention and treatment of gastrointestinal cancer. Gastroent. Res. Pract. 2015;2015:142979.
Ji K., Fang L., Zhao H., Li Q., Shi Y., Xu C., Wang Y., Du L., Wang J., Liu Q. Ginger oleoresin alleviated gamma-ray irradiation-induced reactive oxygen species via the Nrf2 protective response in human mesenchymal stem cells. Oxid. Med. Cell. Longev. 2017;2017:1480294.
Schadich E., Hlavac J., Volna T., Varanasi L., Hajduch M., Dzubak P. Effects of ginger phenylpropanoids and quercetin on Nrf2-ARE pathway in human BJ fibroblasts and HaCaT keratinocytes. Biomed Res. Int. 2016;2016:2173275.
Yeh H., Chuang C., Chen H., Wan C., Chen T., Lin L. Bioactive components analysis of two various gingers (Zingiber officinale Roscoe) and antioxidant effect of ginger extracts. LWT-Food Sci. Technol. 2014;55:329–334.
Poprac P., Jomova K., Simunkova M., Kollar V., Rhodes C.J., Valko M. Targeting free radicals in oxidative stress-related human diseases. Trends Pharmacol. Sci. 2017;38:592–607.
Li S., Li S., Gan R., Song F., Kuang L., Li H. Antioxidant capacities and total phenolic contents of infusions from 223 medicinal plants. Ind. Crop. Prod. 2013;51:289–298.
Deng G., Lin X., Xu X., Gao L., Xie J., Li H. Antioxidant capacities and total phenolic contents of 56 vegetables. J. Funct. Foods. 2013;5:260–266.
Deng G., Xu X., Guo Y., Xia E., Li S., Wu S., Chen F., Ling W., Li H. Determination of antioxidant property and their lipophilic and hydrophilic phenolic contents in cereal grains. J. Funct. Foods. 2012;4:906–914.
Fu L., Xu B., Gan R., Zhang Y., Xu X., Xia E., Li H. Total phenolic contents and antioxidant capacities of herbal and tea infusions. Int. J. Mol. Sci. 2011;12:2112–2124.
Guo Y., Deng G., Xu X., Wu S., Li S., Xia E., Li F., Chen F., Ling W., Li H. Antioxidant capacities, phenolic compounds and polysaccharide contents of 49 edible macro-fungi. Food Funct. 2012;3:1195–1205.
Tysnes O.-B., Storstein A. Epidemiology of Parkinson’s disease. Journal of Neural Transmission. 2017;124(8):901–905.
Li H., Liu Y., Luo D., Ma Y., Zhang J., Li M., Yao L., Shi X., Liu X., Yang K. Ginger for health care: An overview of systematic reviews. Complement. Ther. Med. 2019;45:114–123. doi: 10.1016/j.ctim.2019.06.002.
Weimer K., Schulte J., Maichle A., Muth E.R., Scisco J.L., Horing B., Enck P., Klosterhalfen S. Effects of ginger and expectations on symptoms of nausea in a balanced placebo design. PLoS ONE. 2012;7:e49031. doi: 10.1371/journal.pone.0049031.
Ensiyeh J., Sakineh M.-A.C. Comparing ginger and vitamin B6 for the treatment of nausea and vomiting in pregnancy: A randomised controlled trial. Midwifery. 2009;25:649–653. doi: 10.1016/j.midw.2007.10.013.
Sharifzadeh F., Kashanian M., Koohpayehzadeh J., Rezaian F., Sheikhansari N., Eshraghi N. A comparison between the effects of ginger, pyridoxine (vitamin B6) and placebo for the treatment of the first trimester nausea and vomiting of pregnancy (NVP) J. Matern. Fetal Neonatal Med. 2018;31:2509–2514. doi: 10.1080/14767058.2017.1344965.
Ali B.H., Blunden G., Tanira M.O., Nemmar A. Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): A review of recent research. Food Chem. Toxicol. 2008;46:409–420. doi: 10.1016/j.fct.2007.09.085.
Roshan Kumar, Purabi Saha, Priya Lokare, Kunal Datta, P. Selvakumar, & Anurag Chourasia. (2022). A Systemic Review of Ocimum sanctum (Tulsi): Morphological Characteristics, Phytoconstituents and Therapeutic Applications. International Journal for Research in Applied Sciences and Biotechnology, 9(2), 221–226. https://doi.org/10.31033/ijrasb.9.2.15
Kubra I.R., Rao L.J.M. An impression on current developments in the technology, chemistry, and biological activities of ginger (Zingiber officinale Roscoe) Crit. Rev. Food Sci. Nutr. 2012;52:651–688. doi: 10.1080/10408398.2010.505689.
Nile S.H., Park S.W. Chromatographic analysis, antioxidant, anti-inflammatory, and xanthine oxidase inhibitory activities of ginger extracts and its reference compounds. Ind. Crop. Prod. 2015;70:238–244. doi: 10.1016/j.indcrop.2015.03.033.
Mao Q.-Q., Xu X.-Y., Cao S.-Y., Gan R.-Y., Corke H., Beta T., Li H.-B. Bioactive compounds and bioactivities of ginger (Zingiber officinale Roscoe) Foods. 2019;8:185. doi: 10.3390/foods8060185.
Crichton M., Marshall S., Marx W., McCarthy A.L., Isenring E. Efficacy of ginger (Zingiber officinale) in ameliorating chemotherapy-induced nausea and vomiting and chemotherapy-related outcomes: A systematic review update and meta-analysis. J. Acad. Nutr. Diet. 2019 doi: 10.1016/j.jand.2019.06.009.
Chen C.X., Barrett B., Kwekkeboom K.L. Efficacy of oral ginger (Zingiber officinale) for dysmenorrhea: A systematic review and meta-analysis. Evid.-Based Complement. Altern. Med. 2016;2016:10. doi: 10.1155/2016/6295737.
Zhu J., Chen H., Song Z., Wang X., Sun Z. Effects of ginger (Zingiber officinale Roscoe) on type 2 diabetes mellitus and components of the metabolic syndrome: A systematic review and meta-analysis of randomized controlled trials. Evid.-Based Complement. Altern. Med. 2018;2018:5692962. doi: 10.1155/2018/5692962.
Mozaffari-Khosravi H., Naderi Z., Dehghan A., Nadjarzadeh A., Fallah Huseini H. Effect of ginger supplementation on proinflammatory cytokines in older patients with osteoarthritis: Outcomes of a randomized controlled clinical trial. J. Nutr. Gerontol. Geriatr. 2016;35:209–218. doi: 10.1080/21551197.2016.1206762.
Jiang Y., Turgeon D.K., Wright B.D., Sidahmed E., Ruffin M.T., Brenner D.E., Sen A., Zick S.M. Effect of ginger root on cyclooxygenase-1 and 15-hydroxyprostaglandin dehydrogenase expression in colonic mucosa of humans at normal and increased risk for colorectal cancer. Eur. J. Cancer Prev. 2013;22:455–460. doi: 10.1097/CEJ.0b013e32835c829b.
Moher D., Liberati A., Tetzlaff J., Altman D.G. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. BMJ. 2009;339:b2535. doi: 10.1136/bmj.b2535.
Higgins J.P.T., Altman D.G., Gøtzsche P.C., Jüni P., Moher D., Oxman A.D., Savović J., Schulz K.F., Weeks L., Sterne J.A.C. The cochrane collaboration’s tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928. doi: 10.1136/bmj.d5928.
Marx W., McCarthy A.L., Ried K., McKavanagh D., Vitetta L., Sali A., Lohning A., Isenring E. The effect of a standardized ginger extract on chemotherapy-induced nausea-related quality of life in patients undergoing moderately or highly emetogenic chemotherapy: A double blind, randomized, placebo controlled trial. Nutrients. 2017;9:867. doi: 10.3390/nu9080867.
Thamlikitkul L., Srimuninnimit V., Akewanlop C., Ithimakin S., Techawathanawanna S., Korphaisarn K., Chantharasamee J., Danchaivijitr P., Soparattanapaisarn N. Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin-cyclophosphamide regimen: A randomized, double-blind, placebo-controlled, crossover study. Support Care Cancer. 2017;25:459–464. doi: 10.1007/s00520-016-3423-8.
Li X., Qin Y., Liu W., Zhou X.Y., Li Y.N., Wang L.Y. Efficacy of ginger in ameliorating acute and delayed chemotherapy-induced nausea and vomiting among patients with lung cancer receiving cisplatin-based regimens: A randomized controlled trial. Integr. Cancer. 2018;17:747–754. doi: 10.1177/1534735417753541.
Ansari M., Porouhan P., Mohammadianpanah M., Omidvari S., Mosalaei A., Ahmadloo N., Nasrollahi H., Hamedi S.H. Efficacy of ginger in control of chemotherapy induced nausea and vomiting in breast cancer patients receiving doxorubicin-based chemotherapy. Asian Pac. J. Cancer Prev. 2016;17:3877–3880.
Matsumura M.D., Zavorsky G.S., Smoliga J.M. The effects of pre-exercise ginger supplementation on muscle damage and delayed onset muscle soreness. Phytother. Res. 2015;29:887–893. doi: 10.1002/ptr.5328.
Martins L.B., Rodrigues A., Rodrigues D.F., Dos Santos L.C., Teixeira A.L., Ferreira A.V.M. Double-blind placebo-controlled randomized clinical trial of ginger (Zingiber officinale Rosc) addition in migraine acute treatment. Cephalalgia. 2019;39:68–76. doi: 10.1177/0333102418776016.
Makhdoomi Arzati M., Mohammadzadeh Honarvar N., Saedisomeolia A., Anvari S., Effatpanah M., Makhdoomi Arzati R., Yekaninejad M.S., Hashemi R., Djalali M. The effects of ginger on fasting blood sugar, hemoglobin A1c, and lipid profiles in patients with type 2 diabetes. Int. J. Endocrinol. Metab. 2017;15:e57927. doi: 10.5812/ijem.57927.
Ebrahimzadeh Attari V., Ostadrahimi A., Asghari Jafarabadi M., Mehralizadeh S., Mahluji S. Changes of serum adipocytokines and body weight following zingiber officinale supplementation in obese women: A RCT. Eur. J. Nutr. 2016;55:2129–2136. doi: 10.1007/s00394-015-1027-6.
Ebrahimzadeh Attari V., Asghari Jafarabadi M., Zemestani M., Ostadrahimi A. Effect of zingiber officinale supplementation on obesity management with respect to the uncoupling protein 1 -3826A>G and ß3-adrenergic receptor Trp64Arg polymorphism. Phytother. Res. 2015;29:1032–1039. doi: 10.1002/ptr.5343.
Kumar, R., Saha, P., Kumar, Y., Sahana, S., Dubey, A., & Prakash, O. (2020). A REVIEW ON DIABETES MELLITUS: TYPE1 & TYPE2.
Roshan, K. (2020). Priya damwani, Shivam kumar, Adarsh suman, Suthar Usha. An overview on health benefits and risk factor associated with coffee. International Journal Research and Analytical Review, 7(2), 237-249
C G Awuchi; I O Amagwula, P Priya, R Kumar, U Yezdani, M G Khan. Aflatoxins In Foods And Feeds: A Review On Health Implications, Detection, And Control. Bull. Env. Pharmacol. Life Sci., Vol 9[9] August 2020 : 149-155
Paritakul P., Ruangrongmorakot K., Laosooksathit W., Suksamarnwong M., Puapornpong P. The effect of ginger on breast milk volume in the early postpartum period: A randomized, double-blind controlled trial. Breastfeed. Med. 2016;11:361–365. doi: 10.1089/bfm.2016.0073.
Widana, I.K., Sumetri, N.W., Sutapa, I.K., Suryasa, W. (2021). Anthropometric measures for better cardiovascular and musculoskeletal health. Computer Applications in Engineering Education, 29(3), 550–561. https://doi.org/10.1002/cae.22202
Ryan J.L., Heckler C.E., Roscoe J.A., Dakhil S.R., Kirshner J., Flynn P.J., Hickok J.T., Morrow G.R. Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: A URCC CCOP study of 576 patients. Support Care Cancer. 2012;20:1479–1489. doi: 10.1007/s00520-011-1236-3.
Bind, A., Das, S., Singh, V. D., Kumar, R., Chourasia, A., & Saha, P. Natural Bioactives For The Potential Management Of Gastric Ulceration. Turkish Journal of Physiotherapy and Rehabilitation, 32, 3.
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
![Creative Commons License](http://i.creativecommons.org/l/by-nc-nd/4.0/88x31.png)
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.