Preparation and characterization of hydralazine mouth dissolving tablet by using super-disintegrates

Abstract

Tablet dosage form is the most popular among all existing conventional dosage forms because of its convenience of self-administration, compactness and easy manufacturing. Many patients find it difficult to swallow tablets and capsules. The difficulty is experienced in particular by pediatric and geriatric patients, but it also applies to people who are ill on bed and to those active working patients who are busy or traveling, especially those who have no access to water. Mouth dissolving tablet was prepared by addition of superdisintegrants (Ac-Di-Sol, Sodium starch glycolate and Crospovidone). The tablets were evaluated for their organoleptic (Color, Odor, Taste), physical (Size, Shape and Texture) and quality control parameters (Diameter, Thickness, Hardness, Friability, Disintegration Time and Wetting Time). Hence, mouth dissolving tablets of resinate can be successfully prepared by superdisintegrants, maintaining their disintegration time less than 1 minute, which provide faster effect and better patient compliance. These tablets may be helpful for geriatric and pediatric patients experience difficulty in swallowing conventional tablets, which leads to poor patient compliance. Thus, it was concluded that the method designed for drug resinate complexation and tablet formulation is simple, rapid, cost effective and highly efficient.