Preparation and characterization of hydralazine mouth dissolving tablet by using super-disintegrates
Keywords:
Resinate, Crospovidone, Hydralazine, Mouth Dissolving Tablets, SuperdisintegrantsAbstract
Tablet dosage form is the most popular among all existing conventional dosage forms because of its convenience of self-administration, compactness and easy manufacturing. Many patients find it difficult to swallow tablets and capsules. The difficulty is experienced in particular by pediatric and geriatric patients, but it also applies to people who are ill on bed and to those active working patients who are busy or traveling, especially those who have no access to water. Mouth dissolving tablet was prepared by addition of superdisintegrants (Ac-Di-Sol, Sodium starch glycolate and Crospovidone). The tablets were evaluated for their organoleptic (Color, Odor, Taste), physical (Size, Shape and Texture) and quality control parameters (Diameter, Thickness, Hardness, Friability, Disintegration Time and Wetting Time). Hence, mouth dissolving tablets of resinate can be successfully prepared by superdisintegrants, maintaining their disintegration time less than 1 minute, which provide faster effect and better patient compliance. These tablets may be helpful for geriatric and pediatric patients experience difficulty in swallowing conventional tablets, which leads to poor patient compliance. Thus, it was concluded that the method designed for drug resinate complexation and tablet formulation is simple, rapid, cost effective and highly efficient.
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References
Seager H. Drug-delivery products and the Zydis fast-dissolving dosage, J Pharm Pharmacol. 1998 Apr; 50(4):375-82.
Bagul U. et. al. Manufacturing technologies for mouth dissolving tablets. www.pharmainfo.net, 2006; May 31,
European Directorate for the Quality of Medicine 1988. Pharmeurope, 10(4): 547.
Chang R, Guo X, Burnside BA, Couch RA. Fast Dissolving Tablets. Pharmaceutical Technology 2000; 24(6):52-58.
Kuchekar BS, Badhan C, Mahajan HS. Mouth Dissolving Tablets: A Novel Drug Delivery System. Pharma Times 2003; 35:7-9.
Habib W, Khankari R and Hontz J. Fast-dissolve drug delivery system. Crit. Rev. Ther. Drug Carrier Syst. 2000; 17:61-72.
Wahyuni, S., Chalid, S. M. T., Pelupessy, N. U., Arifuddin, S., Idris, I., & Usman, A. N. (2022). Comparison of the use of shock index and modified early obstetric warning score in COVID-19 obstetric emergency patients as ICU care parameters. International Journal of Health & Medical Sciences, 5(1), 80-90. https://doi.org/10.21744/ijhms.v5n1.1844
Biradar S, Bhagavati S and Kuppasad. Fast dissolving drug delivery system: a brief overview. Internet J. Pharmcol. 2006; 4(2).
Blank R, Mody D, Kenny R and Avenson M. Fast dissolving dosage form. United States Patent 4,946,684. 7th August 1990.
9. Mizumoto T, Masuda Y, Kajiyama A, Yanagisawa M, Nyshadham JR. Tablets Quickly Disintegrating in the Oral Cavity and Process for Producing the Same. US Patent 6,589,554; 2003.
Cousin G, Bruna E, Gendrot E. Rapidly Disintegratable Multiparticular Tablet. US Patent 5,464,632; 1995.
Reilly W.J.; Remington: The Science and Practice of Pharmacy, 20th edition, Mack publishing company, 2002, PP 1018-1020
Bandari S, Mittapalli RK, Gannu R and Rao YM: Orodispersible tablets: an Asian Journal of Pharmaceutics 2008; 2(1): 2-11.
Konapure AS, Chaudhari PS, Oswal RJ, Kshirsagar SS, Antre RV and Chorage TV: Mouth dissolving tablets-an innovative technology. International Journal of Applied Biology and Pharmaceutical Technology 2011; 2(1): 496-503.
Pahwa R, Piplani M, Sharma PC, Kaushik D and Nanda S: Orally disintegrating tablets – friendly to pediatrics and geriatrics. Archives of Applied Science Research 2010; 2(2): 35-48.
Kumar MV, Sethi P, Kheri R, Saraogi GK and Singhai AK: Orally disintegrating tablets: a review. International Research Journal of Pharmacy 2011; 2(4): 16-22.
Giri TK, Tripathi DK and Majumdar R: Formulation aspects in the development of orodispersible tablets: an overview. International Journal of Pharmacy and Pharmaceutical Sciences 2010; 2(3): 38-42.
Agrawal VA, Rajurkar RM, Thonte S and Ingale RG: Fast disintegrating tablets as a new drug delivery system: a review. Pharmacopohore (An International Research Journal) 2011; 2(1): 1-8.
Siddiqui Md.N, Garg G and Sharma PK: Fast Dissolving Tablets: Preparation, Characterization and Evaluation: an overview. International Journal of Pharmaceutical Sciences Review and Research 2010; 4(2): 87-96.
Hirani JJ, Rathod DA and Vadalia RK: Orally disintegrating tablets: a review. Tropical Journal of Pharmaceutical Research 2009; 8(2): 161-172.
Bhowmik D, Chiranjib B, Yadav J, Chandira RM and Kumar S: Emerging trends of disintegrants used in formulation of solid dosage form. Scholars Research Library Der Pharmacia Lettre 2010; 2 (1): 495-504.
Alebiowu G and Itiola OA: The Influence of pregelatinized starch disintegrants on interacting variables that act on disintegrant properties. Pharmaceutical Technology 2003; 28-33.
Goel H, Vora N and Rana V: A novel approach to optimize and formulate fast disintegrating tablets for nausea and vomiting. AAPS PharmSciTech 2008; 9(3): 774-781.
Mohanachandran PS, Sindhumol PG and Kiran TS: Superdisintegrants: an overview. Journal of Pharmaceutical Sciences Review and Research 2011; 6(1): 105-109.
Vaibhav S, Mahaveer PK, Gupta MK, Agarwal D and Sharma N: Orally disintegrating tablet: friendly dosage form. International Journal of Research in Ayurveda and Pharmacy 2010; 1(2): 399-407.
Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Health and treatment of diabetes mellitus. International Journal of Health Sciences, 5(1), i-v. https://doi.org/10.53730/ijhs.v5n1.2864
Ghosh T, Ghosh A and Prasad D: A review on new generation orodispersible tablets and its future prospective. International Journal of Pharmacy and Pharmaceutical Sciences 2011; 3(1): 1-7.
Camarco W, Ray D and Druffner A: Selecting superdisintegrants for orally disintegrating tablet formulations. Pharmaceutical Technology Supplement 2006.
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