To evaluate of antioxidant activity of Costus igneus in ethanol induced peroxidative damage in albino rats

Abstract

The free radical oxidants such as reactive oxygen species, reactive nitrogen species, and reactive sulphur species are produced inside cells through various metabolic processes. The body is equipped with an antioxidant defence system that guards against oxidative damage caused by these reactive oxidants and plays a major role in protecting cells from oxidative stress and damage. Costus igneus possess various pharmacological activities like hypolipidemic, diuretic, antioxidant, anti-microbial, anti-cancerous. Preparation of Costus igneus leaves extract. The leaves of CI were collected from the plants grown. The leaves then were shade-dried and finely powdered; the ethanolic extract is obtained by Soxhlet extraction (20 g in 100 ml of 95% ethanol at 55 °C). The rats were divided into four groups:  Group I: Normal Control rats received 0.9% normal saline.  Group II: Ethanol (20% w/v of 2g/kg body weight). Group III: 20% w/v of 2g/kg ethanol + ethanolic extract of Costus igneus 300 mg/kg body weight.  Group IV: 20% w/v of 2g/kg ethanol + ethanolic extract of Costus igneus 600 mg/kg body weight. All the study groups received treatment through oral route for thirty days at a constant volume of 10 ml/kg.