Formulation and evaluation of fast dissolving oral wafers of linagliptin
Keywords:
Wafers, Linagliptin, Sublingual wafers, polymersAbstract
Wafers are modern oral dosage forms which are commonly used by patients worldwide. Also, in acute pain, these dosage types can be used to get immediate relief. These oral sublingual wafers are nothing more than a thin oral stripe which dissolves immediately due to the presence of saliva in the mouth when placed in the sublingual cavity by releasing medication within a short span of time. The faster dissolution can be achieved by using different superdisintegrants in different concentrations and a comparative study of different superdisintegrants has been carried out. Present investigation aims to formulate fast dissolving wafer of linagliptin using different film forming agents. From the latest research it can be inferred that fast-dissolving oral films of drug release are preferable. The films prepared by HPMC K4 and K15 and CCS and CP had shown strong mechanical power, release of narcotics, period for disintegration and analysis of dissolution. F7 formulation is considered the better with less disintegrating time and release in 10 min according to the results obtained. Percent drug release and disintegration time was taken as responses for study which were found within the accepted ranges.
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Satam, M., N., Bhuruk, M, D., Pawar, Y., D., Fast Dissolving Oral Thin Film: A Review, International Journal Of Universal Pharmacy And Bio Sciences. 2(4): July-August, 27-39. (2013).
Hitesh, D., K., Dasharath, M., P., Ankur kumar R, Chhaganbhai N., P., A Review on Oral Strip. American Journal of PharmaTech Research, 2(3): 61-70 (2012).
Squier, C., Zinc iodide-osmium staining of membrane coating granules in keratinized and non-keratinized mammalian oral epithelium, Archives of Oral Biology 27: 377–382. (1982).
Wertz, P., Swartzendruber, D., Squier, C., Regional variation in the structure and permeability of oral mucosa and skin, Advanced Drug Delivery Reviews 12 1–12. (1993).
Squier, C., Lesch, C., Penetration pathways different compounds through epidermis and oral epithelia, Journal of Oral Pathology & Medicine 17512–516. (1988).
Gnanachaithanya N et.al ‘Formulation and evaluation of fast disintegrating tablets of sitagliptin phosphate’ Int J Ph W Res 2012, vol 3 (3) p.no 1-12. 21.
Handbook of pharmaceutical excipients by Raymond C Rowe. 22. Bentley’s, Rawlins EA, text book of pharmaceutics 8 th edition, 2003, 270-281.
Buchi. N et.al ‘Development and evaluation of fast dissolving films of sumatriptan succinate for better therapeutic efficacy’ Jr App Ph Sci, Aug 2013 vol 3 (8), p.no 161-166. 28.
Narayana raju.p et.al ‘Formulation and evaluation of fast dissolving films of Loratidine by solvent casting method’ The Ph Inn, 2013 vol 2(2), p.no 31-34. 29.
Komaragiri sasi deepthi et.al ‘Formulation and characterization of Atenolol fast dissolving films’ In Jr Ph Sci Res 2012, vol 2 (2) p.no 58- 62. 30.
Pavani.s et.al ‘Formulation development of taste masked disintegrating films of Atenolol’ Inn Int Jr Med Ph Sci, 2017 vol 2 (2) p.no 1-3. 31.
Rakhmonov, O. M., Shadmanov, A. K., & Juraev, F. M. (2021). Results of endoscopic treatment of benign prostatic hyperplasia in patients with metabolic syndrome. International Journal of Health & Medical Sciences, 5(1), 21-25. https://doi.org/10.21744/ijhms.v5n1.1811
Raghavendra rao N.G et.al ‘Design and development of fast dissolving thin films of Losartan pottasium’ Int Jr Ph Sci Dr Res, 2016, vol 8(1) p.no 1-6. 32.
Ralele Swathi et.al ‘Formulation and evaluation of mouth dissolving films of Almotriptan malate’ Jr Ph &Bio Sci, 2015, vol 3, p.no 42-52. 33.
Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Health and treatment of diabetes mellitus. International Journal of Health Sciences, 5(1), i-v. https://doi.org/10.53730/ijhs.v5n1.2864
Kranthi Kumar et.al ‘Formulation and evaluation of Carvedilol fast dissolving films’ Int Jr Ph &An Res, jun 2015, vol 4(2), p.no 116-128
Ali M.S et.al ‘Formulation and evaluation of fast dissolving oral films of Diazepam’ Jr of Pharmacovigilance, 2016 vol 4(3), p.no 1-5. 36.
Alka tomar et.al ‘Formulation and evaluation of fast dissolving oral film of Dicyclomine as potential route of buccal delivery’ Int Jr Dr De &Res Jun 2012, vol 4(2), p.no 408-417. 37.
Anjum pathan et.al ‘Formulation and evaluation of fast dissolving oral film of Promethazine hydrochloride using different surfactant’ Int Jr Ph &Bio Sci, 2016 vol 3(1), p.no 74-84. 38.
Kamalesh Upreti et.al ‘Formulation and evaluation of mouth dissolving films of Paracetamol’ Int Jr Ph &Sci, 2014, vol 6(5), p.no 200-202.
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