Clinical periodontal parameters and sub-gingival bacterial profile in chronic periodontitis patients with and without chronic kidney disease (CKD)
A cross-sectional observational study
Keywords:
bacterial profile, chronic kidney disease, periodontitis, oral healthAbstract
Objectives: To assess the severity of periodontitis and to determine the sub-gingival microbial profile in patients with and without chronic kidney disease (CKD). Methods: A total of 40 patients (18 females and 22 males) were selected for the study and were divided into two groups of twenty each. The test group (Group I) consisted of 20 patients (8 females and 12 males) chronic periodontitis with chronic kidney disease, and control group (Group II) had 20 patients(10 males and 10 females) chronic periodontitis without chronic kidney disease (CKD).Clinical periodontal parameters such as PPD(pocket probing depth),CAL(clinical attachment loss),BOP (bleeding on probing) and Sub-Gingival Bacterial profile. Results: Results of this study suggests that clinical parameters such as PPD (pocket probing depth), CAL(clinical attachment loss), BOP (bleeding on probing) and sub-gingival bacterial profile belonging to red complex are significantly more in patients with CKD. Conclusion: CP presented more severe clinical parameters and is associated with increased frequency of trponema denticolae, tanerella forsythia, porphyromonas gingivalis in patients with CKD.
Downloads
References
Barbato L, Francioni E, Bianchi M, Mascitelli E, Marco LB, Tonelli DP. Periodontitis and bone metabolism. Clin Cases Miner Bone Metab.2015;12:174-177.
Needleman I, Garcia R, Gkranias N, Kirkwood KL, Kocher T, Iorio AD, et al. Mean annual attachment, bone level, and tooth loss: A systematic review. J Clin Periodontol.2018;45:S112-S129.
Wahid A, Chaudhry S, Ehsan A, Butt S, Ali Khan A. Bidirectional relationship between chronic kidney disease & periodontal disease. Pak J Med Sci.2013;29:211-215.
Borawski J, Wilczyńska-Borawska M, Stokowska W, Myśliwiec M. The periodontal status of pre-dialysis chronic kidney disease and maintenance dialysis patients. Nephrol Dial Transplant.2007;22:457-464.
Souza CR, Libério SA, Guerra RN, Monteiro S, Silveira EJ, Pereira AL. [assessment of periodontal condition of kidney patients in hemodialysis]. Rev Assoc Med Bras.2005;51:285-289.
Craig RG. Interactions between chronic renal disease and periodontal disease. Oral Dis.2008; 14:1-7.
Klassen JT, Krasko BM. The dental health status of dialysis patients. J Can Dent Assoc.2002; 68: 34-38.
Duran I, Erdemir EO. Periodontal treatment needs of patients with renal disease receiving haemodialysis. Int Dent J.2004;54: 274-278.
Chen LP, Chiang CK, Chan CP, Hung KY, Huang CS. Does periodontitis reflect inflammation and malnutrition status in hemodialysis patients? Am J Kidney Dis.2006;47:815-822.
Thorman R, Neovius M, Hylander B. Clinical findings in oral health during progression of chronic kidney disease to end-stage renal disease in a swedish population. Scand J Urol Nephrol.2009; 43:154-159.
Rahmati MA, Craig RG, Homel P, Kaysen GA, Levin NW. Serum markers of periodontal disease status and inflammation in hemodialysis patients. Am J Kidney Dis.2002;40:983-989.
Takeuchi Y, Ishikawa H, Inada M, Shinozuka O, Umeda M, Yamazaki T, et al. Study of the oral microbial flora in patients with renal disease. Nephrology.2007;12:182-190.
Bastos JA, Diniz CG, Bastos MG, Vilela EM, Silva VL, Chaoubah A, et al. Identification of periodontal pathogens and severity of periodontitis in patients with and without chronic kidney disease. Arch Oral Biol.2011;56:804-811.
Page RC, Eke PI. Case definitions for use in population-based surveillance of periodontitis. J Periodontol.2007;78:1387-1399.
K/doqi clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification. Am J Kidney Dis.2002;39:S1-266.
Syed SA, Svanberg M, Svanberg G. The predominant cultivable dental plaque flora of beagle dogs with gingivitis. J Periodontal Res.1980;15:123-136.
Newbrun E. Indices to measure gingival bleeding. J Periodontol.1996;67:555-561.
Sorsa T, Ingman T, Suomalainen K, Haapasalo M, Konttinen YT, Lindy O, et al. Identification of proteases from periodontopathogenic bacteria as activators of latent human neutrophil and fibroblast-type interstitial collagenases. Infect Immun.1992;60:4491-1495.
Prabhu A, Michalowicz BS, Mathur A. Detection of local and systemic cytokines in adult periodontitis. J Periodontol.1996;67:515-522.
Leivadaros E, van der Velden U, Bizzarro S, ten Heggeler JM, Gerdes VE, Hoek FJ, et al. A pilot study into measurements of markers of atherosclerosis in periodontitis. J Periodontol.2005;76:121-128.
Levey AS, Coresh J, Balk E, Kausz AT, Levin A, Steffes MW, et al. National kidney foundation practice guidelines for chronic kidney disease: Evaluation, classification, and stratification. Ann Intern Med.2003;139:137-147.
Shoji T, Abe T, Matsuo H, Egusa G, Yamasaki Y, Kashihara N, et al. Chronic kidney disease, dyslipidemia, and atherosclerosis. J Atheroscler Thromb.2012;19:299-315.
Levey AS, de Jong PE, Coresh J, Nahas MEl, Astor BC, Matsushita K, et al. The definition, classification, and prognosis of chronic kidney disease: A kdigo controversies conference report. Kidney International.2011;80:17-28.
Stenvinkel P. New insights on inflammation in chronic kidney disease-genetic and non-genetic factors. Nephrol Ther.2006; 2:111-119.
Kshirsagar AV, Offenbacher S, Moss KL, Barros SP, Beck JD. Antibodies to periodontal organisms are associated with decreased kidney function. The dental atherosclerosis risk in communities study. Blood Purif .2007;25:125-132.
Fisher MA, Taylor GW, Papapanou PN, Rahman M, Debanne SM. Clinical and serologic markers of periodontal infection and chronic kidney disease. J Periodontol 2008; 79: 1670-78.
Paraskevas S, Huizinga JD, Loos BG. A systematic review and meta-analyses on c-reactive protein in relation to periodontitis. J Clin Periodontol.2008;35:277-290.
Brotto RS, Vendramini RC, Brunetti IL, Marcantonio RAC, Ramos APP, Pepato MT. Lack of correlation between periodontitis and renal dysfunction in systemically healthy patients. Eur J Dent.2011; 5: 8-18.
Grubbs V, Plantinga LC, Crews DC, Bibbins-Domingo K, Saran R, Heung M, et al. Vulnerable populations and the association between periodontal and chronic kidney disease. Clin J Am Soc Nephrol.2011; 6: 711-717.
Davidovich E, Davidovits M, Eidelman E, Schwarz Z, Bimstein E. Pathophysiology, therapy, and oral implications of renal failure in children and adolescents: An update. Pediatr Dent.2005; 27: 98-106.
Nylund KM, Meurman JH, Heikkinen AM, Furuholm JO, Ortiz F, Ruokonen HM. Oral health in patients with renal disease: A longitudinal study from predialysis to kidney transplantation. Clin Oral Investig.2018; 22:339-347.
Bayraktar G, Kurtulus I, Duraduryan A, Cintan S, Kazancioglu R, Yildiz A, et al. Dental and periodontal findings in hemodialysis patients. Oral Dis.2007; 13:393-397.
Shultis WA, Weil EJ, Looker HC, Curtis JM, Shlossman M, Genco RJ, et al. Effect of periodontitis on overt nephropathy and end-stage renal disease in type 2 diabetes. Diabetes Care.2007; 30: 306-311.
Anand S, Shivashankar R, Ali MK, Kondal D, Binukumar B, Montez-Rath ME, et al. Prevalence of chronic kidney disease in two major indian cities and projections for associated cardiovascular disease. Kidney international.2015; 88:178-185.
Rosamma J, Rajaratnam K, Vivek N. Higher prevalence of periodontal disease among patients with predialytic renal disease. Brazilian Journal of Oral Sciences.2015; 8.
Castillo A, Mesa F, Liébana J, García-Martinez O, Ruiz S, García-Valdecasas J, et al. Periodontal and oral microbiological status of an adult population undergoing haemodialysis: A cross-sectional study. Oral Dis 2007; 13: 198-205.
Nadeem M, Stephen L, Schubert C, Davids MR. Association between periodontitis and systemic inflammation in patients with end-stage renal disease. SADJ.2009; 64:470-473.
Rahman, N. M., Made, S., Usman, A. N., Idris, I., Unde, A., & Bahar, B. (2022). Analysis of understanding of midwife students of midwife care as the impact of online learning. International Journal of Health & Medical Sciences, 5(1), 63-66. https://doi.org/10.21744/ijhms.v5n1.1834
Widana, I.K., Dewi, G.A.O.C., Suryasa, W. (2020). Ergonomics approach to improve student concentration on learning process of professional ethics. Journal of Advanced Research in Dynamical and Control Systems, 12(7), 429-445.
Widana, I.K., Sumetri, N.W., Sutapa, I.K., Suryasa, W. (2021). Anthropometric measures for better cardiovascular and musculoskeletal health. Computer Applications in Engineering Education, 29(3), 550–561. https://doi.org/10.1002/cae.22202
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
![Creative Commons License](http://i.creativecommons.org/l/by-nc-nd/4.0/88x31.png)
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.