Biomaterials in dentistry: Advances in tissue engineering for dental restoration

https://doi.org/10.53730/ijhs.v8nS1.15035

Authors

  • Reem Saleh Alonazi KSA, National Guard Health Affairs
  • Hissah Abdulkarim Alqubaysi KSA, National Guard Health Affairs
  • Noura Hamed Al-Mutairi KSA, National Guard Health Affairs

Keywords:

Biomaterials, Dental Implants, Drug Delivery Systems, Additive Manufacturing, Nanotechnology, Hydroxyapatite, Calcium Phosphate

Abstract

Background: In regenerative medicine, advances in biomaterials have significantly impacted various medical fields, including dentistry. The use of implants, both metallic and non-metallic, has raised concerns about bacterial adhesion and biofilm formation, which can lead to complications such as peri-implantitis. Innovations in drug delivery systems and additive manufacturing technologies offer new solutions to these challenges. Methods: The review explores recent developments in biomaterials for dental restoration, focusing on drug-eluting implants, additive manufacturing, nanotechnology, and biocompatible coatings. The study evaluates the effectiveness of various drug delivery systems, including hydrogels, nanoparticles, and polymers, and discusses advancements in 3D printing and surface coatings. Results: Additive manufacturing technologies, such as 3D printing, have enabled the creation of precise models and drug delivery systems. Nanotechnology has introduced new materials with improved antimicrobial properties and targeted drug delivery capabilities. Innovations in coatings, such as hydroxyapatite (HA) and calcium phosphate, have enhanced osseointegration and reduced infection risks. Additionally, nanomaterials like gold and silver nanoparticles have shown promise in improving implant functionality and reducing bacterial colonization. Conclusion: Advances in biomaterials and manufacturing technologies have significantly improved the effectiveness and safety of dental implants.

Downloads

Download data is not yet available.

References

Pokrowiecki R, Szałaj U, Fudala D, Zaręba T, Wojnarowicz J, Łojkowski W, et al. Dental Implant Healing screws as Temporary oral drug Delivery systems for decrease of infections in the area of the Head and Neck. Int J Nanomed. 2022;17:1679–93.

Brunello G, Brun P, Gardin C, Ferroni L, Bressan E, Meneghello R, et al. Biocompatibility and antibacterial properties of zirconium nitride coating on titanium abutments: an in vitro study. PLoS ONE. 2018;13(6):e0199591.

Tebyaniyan H, Hussain A, Vivian M. Current antibacterial agents in dental bonding systems: a comprehensive overview. Future Microbiol. 2023.

Tahmasebi E, Keshvad A, Alam M, Abbasi K, Rahimi S, Nouri F, et al. Current infections of the Orofacial Region: treatment, diagnosis, and Epidemiology. Life [Internet]. 2023;13(2):269.

Bennardo F, Gallelli L, Palleria C, Colosimo M, Fortunato L, De Sarro G, et al. Can platelet-rich fibrin act as a natural carrier for antibiotics delivery? A proof-of-concept study for oral surgical procedures. BMC Oral Health. 2023;23(1):134.

Alshimaysawee S, Fadhel Obaid R, Al-Gazally ME, Alexis Ramírez-Coronel A, Bathaei MS. Recent advancements in metallic drug-eluting implants. Pharmaceutics. 2023;15(1).

Mosaddad SA, Talebi S, Hemmat M, Karimi M, Jahangirnia A, Alam M et al. Oral complications Associated with the piercing of oral and Perioral Tissues and the corresponding degree of awareness among Public and professionals: a systematic review. Diagnostics [Internet]. 2023; 13(21).

Alarcón-Sánchez MA, Becerra-Ruíz JS, Yessayan L, Mosaddad SA, Heboyan A. Implant-supported prosthetic rehabilitation after Ameloblastomas treatment: a systematic review. BMC Oral Health. 2023;23(1):1013.

Alqahtani AR, Desai SR, Patel JR, Alqhtani NR, Alqahtani AS, Heboyan A, et al. Investigating the impact of diameters and thread designs on the Biomechanics of short implants placed in D4 bone: a 3D finite element analysis. BMC Oral Health. 2023;23(1):686.

González-Henríquez CM, Sarabia-Vallejos MA, Rodríguez Hernandez J. Antimicrobial polymers for Additive Manufacturing. Int J Mol Sci. 2019;20(5).

Mosaddad SA, Hussain A, Tebyaniyan H. Exploring the Use of Animal models in Craniofacial Regenerative Medicine: a narrative review. Reviews: Tissue engineering Part B; 2023.

Antonelli A, Barone S, Attanasio F, Salviati M, Cerra MG, Calabria E et al. Effect of Implant Macro-design and Magnetodynamic Surgical Preparation on Primary Implant Stability: an in Vitro Investigation. Dentistry J [Internet]. 2023; 11(10).

Baskaran P, Prakash PSG, Appukuttan D, Mugri MH, Sayed M, Subramanian S et al. Clinical and radiological outcomes for guided Implant Placement in sites preserved with bioactive glass bone graft after tooth extraction: a controlled clinical trial. Biomimetics [Internet]. 2022; 7(2).

Bennardo F, Liborio F, Barone S, Antonelli A, Buffone C, Fortunato L, et al. Efficacy of platelet-rich fibrin compared with triamcinolone acetonide as injective therapy in the treatment of symptomatic oral lichen planus: a pilot study. Clin Oral Invest. 2021;25(6):3747–55.

Khorsandi D, Fahimipour A, Abasian P, Saber SS, Seyedi M, Ghanavati S, et al. 3D and 4D printing in dentistry and maxillofacial surgery: Printing techniques, materials, and applications. Acta Biomater. 2021;122:26–49.

Mosaddad SA, Hussain A, Tebyaniyan H. Green Alternatives as Antimicrobial agents in Mitigating Periodontal diseases: a narrative review. Microorganisms [Internet]. 2023; 11(5).

Khayatan D, Hussain A, Tebyaniyan H. Exploring animal models in oral cancer research and clinical intervention: a critical review. Vet Med Sci. 2023.

Heboyan A, Vardanyan A, Karobari MI, Marya A, Avagyan T, Tebyaniyan H, et al. Dent Luting Cements: Updated Compr Rev Molecules [Internet]. 2023;28(4):1619. p.].

Desai SR, Koulgikar KD, Alqhtani NR, Alqahtani AR, Alqahtani AS, Alenazi A et al. Three-dimensional FEA analysis of the stress distribution on Titanium and Graphene Frameworks supported by 3 or 6-Implant models. Biomimetics [Internet]. 2023; 8(1).

Fernandes G, Ferreira N, Heboyan A, Nassani L, Pereira R, Fernandes J. Clinical Assessment of Short (> 6 mm and ≤ 8.5 mm) implants in posterior sites with an average Follow-Up of 74 months: a retrospective study. Int J Oral Maxillofac Implants. 2023;38(5):915–26.

Giudice A, Attanasio F, Bennardo F, Antonelli A, Vercellotti T. Usefulness of wedge-shaped implants in the full-arch rehabilitation of severe maxillary atrophy: a case report. Int J Periodontics Restor Dentistry. 2023;0(0):–.

Bennardo F, Barone S, Vocaturo C, Gheorghe DN, Cosentini G, Antonelli A et al. Comparison between Magneto-Dynamic, Piezoelectric, and conventional surgery for Dental extractions: a pilot study. Dent J (Basel). 2023;11(3).

Hakim LK, Yazdanian M, Alam M, Abbasi K, Tebyaniyan H, Tahmasebi E, et al. Biocompatible and Biomaterials Application in Drug Delivery System in oral cavity. Evid Based Complement Alternat Med. 2021;2021:9011226.

Mondal S, Park S, Choi J, Vu TTH, Doan VHM, Vo TT, et al. Hydroxyapatite: a journey from biomaterials to advanced functional materials. Adv Colloid Interface Sci. 2023;321:103013.

Munir MU, Salman S, Javed I, Bukhari SNA, Ahmad N, Shad NA, et al. Nano-Hydroxyapatite as a delivery system: overview and advancements. Artif Cells Nanomed Biotechnol. 2021;49(1):717–27.

Pardun K, Treccani L, Volkmann E, Streckbein P, Heiss C, Li Destri G, et al. Mixed zirconia calcium phosphate coatings for dental implants: tailoring coating stability and bioactivity potential. Mater Sci Eng C Mater Biol Appl. 2015;48:337–46.

Shi Q, Qian Z, Liu D, Liu H. Surface modification of Dental Titanium Implant by Layer-by-layer Electrostatic Self-Assembly. Front Physiol. 2017;8:574.

Sukumaran A, Asala FA-S, Ansar EB, Elna PC, Harikrishna PRV, Mohammad DAA. Drug Delivery systems in Bone Regeneration and Implant Dentistry. In: Ilser T, editor. Current concepts in Dental Implantology. Rijeka: IntechOpen; 2015. Ch. 10.

Yeo IL. Modifications of Dental Implant surfaces at the Micro- and Nano-Level for enhanced osseointegration. Mater (Basel Switzerland). 2019;13(1).

Meyer M. Processing of collagen based biomaterials and the resulting materials properties. Biomed Eng Online. 2019;18(1):24.

Yazdanian M, Rostamzadeh P, Rahbar M, Alam M, Abbasi K, Tahmasebi E, et al. The potential application of Green-Synthesized Metal nanoparticles in Dentistry: a Comprehensive Review. Bioinorg Chem Appl. 2022;2022:2311910.

Yazdanian M, Rostamzadeh P, Alam M, Abbasi K, Tahmasebi E, Tebyaniyan H, et al. Evaluation of antimicrobial and cytotoxic effects of Echinacea and Arctium extracts and Zataria essential oil. AMB Express. 2022;12(1):75.

Manchon A, Prados-Frutos JC, Rueda-Rodriguez C, Salinas-Goodier C, Alkhraisat MH, Rojo R, et al. Antibiotic release from calcium phosphate materials in oral and maxillofacial surgery. Molecular, Cellular and Pharmaceutical aspects. Curr Pharm Biotechnol. 2017;18(1):52–63.

Canal C, Modic M, Cvelbar U, Ginebra MP. Regulating the antibiotic drug release from β-tricalcium phosphate ceramics by atmospheric plasma surface engineering. Biomater Sci. 2016;4(10):1454–61.

Tebyanian H, Norahan MH, Eyni H, Movahedin M, Mortazavi SJ, Karami A, et al. Effects of collagen/beta-tricalcium phosphate bone graft to regenerate bone in critically sized rabbit calvarial defects. J Appl Biomater Funct Mater. 2019;17(1):2280800018820490.

Barzegar PEF, Ranjbar R, Yazdanian M, Tahmasebi E, Alam M, Abbasi K, et al. The current natural/chemical materials and innovative technologies in periodontal diseases therapy and regeneration: a narrative review. Mater Today Commun. 2022;32:104099.

Tollemar V, Collier ZJ, Mohammed MK, Lee MJ, Ameer GA, Reid RR. Stem cells, growth factors and scaffolds in craniofacial regenerative medicine. Genes Dis. 2016;3(1):56–71.

Duan X, Bradbury SR, Olsen BR, Berendsen AD. VEGF stimulates intramembranous bone formation during craniofacial skeletal development. Matrix Biol. 2016;52–54:127–40.

Francis CS, Mobin SSN, Lypka MA, Rommer E, Yen S, Urata MM, et al. rhBMP-2 with a demineralized bone matrix scaffold versus autologous iliac crest bone graft for alveolar cleft reconstruction. Plast Reconstr Surg. 2013;131(5):1107–15.

Bari E, Di Gravina GM, Scocozza F, Perteghella S, Frongia B, Tengattini S et al. Silk Fibroin Bioink for 3D Printing in tissue regeneration: controlled release of MSC extracellular vesicles. Pharmaceutics. 2023;15(2).

Azevedo HS, Pashkuleva I. Biomimetic supramolecular designs for the controlled release of

Lee SH, Shin H. Matrices and scaffolds for delivery of bioactive molecules in bone and cartilage tissue engineering. Adv Drug Deliv Rev. 2007;59(4–5):339–59.

Abuarqoub D, Theeb LS, Omari MB, Hamadneh YI, Alrawabdeh JA, Aslam N, et al. The osteogenic role of Biomaterials Combined with Human-Derived Dental Stem cells in bone tissue regeneration. Tissue Eng Regen Med; 2023.

Patel ZS, Young S, Tabata Y, Jansen JA, Wong ME, Mikos AG. Dual delivery of an angiogenic and an osteogenic growth factor for bone regeneration in a critical size defect model. Bone. 2008;43(5):931–40.

King WJ, Krebsbach PH. Growth factor delivery: how surface interactions modulate release in vitro and in vivo. Adv Drug Deliv Rev. 2012;64(12):1239–56.

Triplett RG, Nevins M, Marx RE, Spagnoli DB, Oates TW, Moy PK, et al. Pivotal, randomized, parallel evaluation of recombinant human bone morphogenetic protein-2/absorbable collagen sponge and autogenous bone graft for maxillary sinus floor augmentation. J Oral Maxillofac Surg. 2009;67(9):1947–60.

Guo J, Yao H, Li X, Chang L, Wang Z, Zhu W, et al. Advanced Hydrogel systems for mandibular reconstruction. Bioact Mater. 2023;21:175–93.

Kretlow JD, Young S, Klouda L, Wong M, Mikos AG. Injectable biomaterials for regenerating complex craniofacial tissues. Adv Mater. 2009;21(32–33):3368–93.

Mehta M, Schmidt-Bleek K, Duda GN, Mooney DJ. Biomaterial delivery of morphogens to mimic the natural healing cascade in bone. Adv Drug Deliv Rev. 2012;64(12):1257–76.

Liu Z, Xu Z, Wang X, Zhang Y, Wu Y, Jiang D, et al. Preparation and Biocompatibility of Core-Shell Microspheres for Sequential, sustained release of BMP-2 and VEGF. Biomed Res Int. 2022;2022:4072975.

Zhang ZD, Xu YQ, Chen F, Luo JF, Liu CD. Sustained delivery of vascular endothelial growth factor using a dextran/poly(lactic-co-glycolic acid)-combined microsphere system for therapeutic neovascularization. Heart Vessels. 2019;34(1):167–76.

Howell TH, Fiorellini JP, Paquette DW, Offenbacher S, Giannobile WV, Lynch SE. A phase I/II clinical trial to evaluate a combination of recombinant human platelet-derived growth factor-BB and recombinant human insulin-like growth factor-I in patients with periodontal disease. J Periodontol. 1997;68(12):1186–93.

Lin H, Chen H, Zhao X, Chen Z, Zhang P, Tian Y, et al. Advances in mesenchymal stem cell conditioned medium-mediated periodontal tissue regeneration. J Transl Med. 2021;19(1):456.

Souza JCM, Sordi MB, Kanazawa M, Ravindran S, Henriques B, Silva FS, et al. Nano-scale modification of titanium implant surfaces to enhance osseointegration. Acta Biomater. 2019;94:112–31.

Tafazoli Moghadam E, Yazdanian M, Alam M, Tebyanian H, Tafazoli A, Tahmasebi E, et al. Current natural bioactive materials in bone and tooth regeneration in dentistry: a comprehensive overview. J Mater Res Technol. 2021;13:2078–114.

Niakan S, Mahgoli H, Afshari A, Mosaddad SA, Afshari A. Conventional maxillary denture versus maxillary implant-supported overdenture opposing mandibular implant-supported overdenture: Patient’s satisfaction. Clinical and experimental dental research. 2023.

Mirchandani B, Zhou T, Heboyan A, Yodmongkol S, Buranawat B. Biomechanical aspects of various attachments for Implant overdentures: a review. Polym [Internet]. 2021; 13(19).

Tahmasebi E, Alam M, Yazdanian M, Tebyanian H, Yazdanian A, Seifalian A, et al. Current biocompatible materials in oral regeneration: a comprehensive overview of composite materials. J Mater Res Technol. 2020;9(5):11731–55.

Nair S, Madhav VNV, Saini RS, Alshadidi AAF, Aldosari LIN, Heboyan A. 28Assessment of thermal variations in the pulpal chamber during fabrication of provisionals using two different techniques and three materials. Technol Health Care. 2023;Preprint:1–13.

Taghva M, Mosaddad SA, Ansarifard E, Sadeghi M. Could various angulated implant depths affect the positional accuracy of digital impressions? An in vitro study. J Prosthodontics: Official J Am Coll Prosthodontists. 2023.

Najmi MA, Nayab T, Alam BF, Abbas T, Ashgar S, Hussain T, et al. Role of mineral trioxide aggregate in dentistry: a bibliometric analysis using Scopus database. J Appl Biomater Funct Mater. 2023;21:22808000231154065.

Golfeshan F, Mosaddad SA, Alamdarloo Y, Motamedifar M, Hatamipoor Dehno F. Effect of incorporating Punica granatum extract in acrylic resins on Streptococcus mutans and Candida albicans: a preliminary study. J Herb Med. 2023;42:100770.

Mosaddad SA, Yazdanian M, Tebyanian H, Tahmasebi E, Yazdanian A, Seifalian A, et al. Fabrication and properties of developed collagen/strontium-doped Bioglass scaffolds for bone tissue engineering. J Mater Res Technol. 2020;9(6):14799–817.

Patel V, Sadiq MS, Najeeb S, Khurshid Z, Zafar MS, Heboyan A. Effects of metformin on the bioactivity and osseointegration of dental implants: a systematic review. J Taibah Univ Med Sci. 2023;18(1):196–206.

Patil P, Madhav VNV, Alshadidi AAF, Saini RS, Aldosari LIN, Heboyan A, et al. Comparative evaluation of open tray impression technique: investigating the precision of four splinting materials in multiple implants. BMC Oral Health. 2023;23(1):844.

Saini RS, Mosaddad SA, Heboyan A. Application of density functional theory for evaluating the mechanical properties and structural stability of dental implant materials. BMC Oral Health. 2023;23(1):958.

Tanweer N, Qazi F-U-R, Das G, Bilgrami A, Basha S, Ahmed N et al. Effect of Erosive agents on Surface characteristics of Nano-Fluorapatite Ceramic: an In-Vitro Study. Molecules [Internet]. 2022; 27(15).

Tahmasebi E, Mohammadi M, Yazdanian M, Alam M, Abbasi K, Hosseini HM et al. Antimicrobial properties of green synthesized novel TiO2 nanoparticles using Iranian propolis extracts. J Basic Microbiol. 2023;n/a(n/a)

Yazdanian M, Tabesh H, Houshmand B, Tebyanian H, Soufdoost RS, Tahmasebi E, et al. Fabrication and properties of βTCP/Zeolite/Gelatin scaffold as developed scaffold in bone regeneration: in vitro and in vivo studies. Biocybernetics and Biomedical Engineering. 2020;40(4):1626–37.

Wajdan N, Aslam K, Amin R, Khan S, Ahmed N, Lal A, et al. Anti-fungal efficacy of Miswak Extract (Salvadora Persica) and commercial cleaner against Candida albicans on heat cured polymethylmethacrylate denture base. J Appl Biomater Funct Mater. 2023;21:22808000231165666.

Schünemann FH, Galárraga-Vinueza ME, Magini R, Fredel M, Silva F, Souza JCM et al. Zirconia surface modifications for implant dentistry. Materials science & engineering C, Materials for biological applications. 2019;98:1294 – 305.

Vishwakarma A, Bhise NS, Evangelista MB, Rouwkema J, Dokmeci MR, Ghaemmaghami AM, et al. Engineering Immunomodulatory Biomaterials to Tune the Inflammatory response. Trends Biotechnol. 2016;34(6):470–82.

Jenney CR, Anderson JM. Adsorbed serum proteins responsible for surface dependent human macrophage behavior. J Biomed Mater Res. 2000;49(4):435–47.

Tang L, Eaton JW. Fibrin(ogen) mediates acute inflammatory responses to biomaterials. J Exp Med. 1993;178(6):2147–56.

Sivaraman B, Latour RA. The relationship between platelet adhesion on surfaces and the structure versus the amount of adsorbed fibrinogen. Biomaterials. 2010;31(5):832–9.

Morais JM, Papadimitrakopoulos F, Burgess DJ. Biomaterials/tissue interactions: possible solutions to overcome foreign body response. Aaps j. 2010;12(2):188–96.

Schlundt C, El Khassawna T, Serra A, Dienelt A, Wendler S, Schell H, et al. Macrophages in bone fracture healing: their essential role in endochondral ossification. Bone. 2018;106:78–89.

Wang J, Qian S, Liu X, Xu L, Miao X, Xu Z, et al. M2 macrophages contribute to osteogenesis and angiogenesis on nanotubular TiO(2) surfaces. J Mater Chem B. 2017;5(18):3364–76.

Zhang R, Liang Y, Wei S. M2 macrophages are closely associated with accelerated clavicle fracture healing in patients with traumatic brain injury: a retrospective cohort study. J Orthop Surg Res. 2018;13(1):213.

Chen Z, Bachhuka A, Han S, Wei F, Lu S, Visalakshan RM, et al. Tuning Chemistry and Topography of Nanoengineered surfaces to manipulate Immune response for bone regeneration applications. ACS Nano. 2017;11(5):4494–506.

Sheikh Z, Drager J, Zhang YL, Abdallah MN, Tamimi F, Barralet J. Controlling Bone Graft Substitute microstructure to improve bone augmentation. Adv Healthc Mater. 2016;5(13):1646–55.

Dziki JL, Badylak SF. Immunomodulatory biomaterials. Curr Opin Biomedical Eng. 2018;6:51–7.

Schaefer L. Complexity of danger: the diverse nature of damage-associated molecular patterns. J Biol Chem. 2014;289(51):35237–45.

Cho Y, Hong J, Ryoo H, Kim D, Park J, Han J. Osteogenic responses to zirconia with hydroxyapatite coating by aerosol deposition. J Dent Res. 2015;94(3):491–9.

Kim SG, Hahn BD, Park DS, Lee YC, Choi EJ, Chae WS, et al. Aerosol deposition of hydroxyapatite and 4-hexylresorcinol coatings on titanium alloys for dental implants. J oral Maxillofacial Surgery: Official J Am Association Oral Maxillofacial Surg. 2011;69(11):e354–63.

Lee SW, Hahn BD, Kang TY, Lee MJ, Choi JY, Kim MK, et al. Hydroxyapatite and collagen combination-coated dental implants display better bone formation in the peri-implant area than the same combination plus bone morphogenetic protein-2-coated implants, hydroxyapatite only coated implants, and uncoated implants. J oral Maxillofacial Surgery: Official J Am Association Oral Maxillofacial Surg. 2014;72(1):53–60.

Laranjeira MS, Carvalho Â, Pelaez-Vargas A, Hansford D, Ferraz MP, Coimbra S, et al. Modulation of human dermal microvascular endothelial cell and human gingival fibroblast behavior by micropatterned silica coating surfaces for zirconia dental implant applications. Sci Technol Adv Mater. 2014;15(2):025001.

Kunrath MF, Shah FA, Dahlin C. Bench-to-bedside: feasibility of nano-engineered and drug-delivery biomaterials for bone-anchored implants and periodontal applications. Mater Today Bio. 2023;18:100540.

Yazdanian M, Rahmani A, Tahmasebi E, Tebyanian H, Yazdanian A, Mosaddad SA. Current and advanced nanomaterials in Dentistry as Regeneration agents: an update. Mini Rev Med Chem. 2021;21(7):899–918.

Kavoosi F, Modaresi F, Sanaei M, Rezaei Z. Medical and dental applications of nanomedicines. APMIS: acta pathologica, microbiologica, et immunologica. Scandinavica. 2018;126(10):795–803.

Hussain A, Tebyaniyan H, Khayatan D. The role of Epigenetic in Dental and oral regenerative medicine by different types of Dental Stem cells: a comprehensive overview. Stem Cells Int. 2022;2022:5304860.

Soudi A, Yazdanian M, Ranjbar R, Tebyanian H, Yazdanian A, Tahmasebi E, et al. Role and application of stem cells in dental regeneration: a comprehensive overview. EXCLI J. 2021;20:454–89.

Gong T, Xie J, Liao J, Zhang T, Lin S, Lin Y. Nanomaterials and bone regeneration. Bone Res. 2015;3:15029.

Bapat RA, Dharmadhikari S, Chaubal TV, Amin M, Bapat P, Gorain B, et al. The potential of dendrimer in delivery of therapeutics for dentistry. Heliyon. 2019;5(10):e02544.

Bapat RA, Chaubal TV, Dharmadhikari S, Abdulla AM, Bapat P, Alexander A, et al. Recent advances of gold nanoparticles as biomaterial in dentistry. Int J Pharm. 2020;586:119596.

Sivolella S, Stellini E, Brunello G, Gardin C, Ferroni L, Bressan E, et al. Silver nanoparticles in alveolar bone surgery devices. J Nanomaterials. 2012;2012:1–12.

Noronha VT, Paula AJ, Durán G, Galembeck A, Cogo-Müller K, Franz-Montan M, et al. Silver nanoparticles in dentistry. Dent Materials: Official Publication Acad Dent Mater. 2017;33(10):1110–26.

Svensson S, Suska F, Emanuelsson L, Palmquist A, Norlindh B, Trobos M, et al. Osseointegration of titanium with an antimicrobial nanostructured noble metal coating. Nanomedicine: Nanatechnol Biology Med. 2013;9(7):1048–56.

Zhu Y, Cao H, Qiao S, Wang M, Gu Y, Luo H, et al. Hierarchical micro/nanostructured titanium with balanced actions to bacterial and mammalian cells for dental implants. Int J Nanomed. 2015;10:6659–74.

Shakeri F, Latifi AM, Mirzaii M, Babavalian H, Tebyanian H. Introduction of fungal necrosis inducing phytotoxin for biocontrol of Sinapis arvensis as a common weed in Iran. J Anim Plant Sci. 2017;27(5):1702–10.

Flores CY, Miñán AG, Grillo CA, Salvarezza RC, Vericat C, Schilardi PL. Citrate-capped silver nanoparticles showing good bactericidal effect against both planktonic and sessile bacteria and a low cytotoxicity to osteoblastic cells. ACS Appl Mater Interfaces. 2013;5(8):3149–59.

Qiao S, Cao H, Zhao X, Lo H, Zhuang L, Gu Y, et al. Ag-plasma modification enhances bone apposition around titanium dental implants: an animal study in Labrador dogs. Int J Nanomed. 2015;10:653–64.

Bennardo F, Barone S, Buffone C, Colangeli W, Antonelli A, Giudice A. Removal of dental implants displaced into the maxillary sinus: a retrospective single-center study. Head Face Med. 2022;18(1):34.

Barik A, Chakravorty N. Targeted drug delivery from Titanium implants: a Review of challenges and approaches. Adv Exp Med Biol. 2020;1251:1–17.

Guo T, Scimeca JC, Ivanovski S, Verron E, Gulati K. Enhanced Corrosion Resistance and local therapy from Nano-Engineered Titanium Dental implants. Pharmaceutics. 2023;15(2).

Pushpalatha C, Suresh J, Gayathri VS, Sowmya SV, Augustine D, Alamoudi A, et al. Zinc oxide nanoparticles: a review on its applications in Dentistry. Front Bioeng Biotechnol. 2022;10:917990.

Xiang Y, Li J, Liu X, Cui Z, Yang X, Yeung KWK et al. Construction of poly(lactic-co-glycolic acid)/ZnO nanorods/Ag nanoparticles hybrid coating on Ti implants for enhanced antibacterial activity and biocompatibility. Materials science & engineering C, Materials for biological applications. 2017;79:629 – 37.

Goel S, Dubey P, Ray S, Jayaganthan R, Pant AB, Chandra R. Co-sputtered antibacterial and biocompatible nanocomposite titania-zinc oxide thin films on Si substrates for dental implant applications. Mater Technol. 2019;34(1):32–42.

Heboyan A, Marya A, Syed AUY, Khurshid Z, Zafar MS, Rokaya D, et al. in Vitro Microscopic evaluation of metal- and zirconium-oxide-based crowns’ marginal Fit. Volume 22. Pesquisa Brasileira em Odontopediatria e Clínica Integrada; 2022.

Memarzadeh K, Sharili AS, Huang J, Rawlinson SC, Allaker RP. Nanoparticulate zinc oxide as a coating material for orthopedic and dental implants. J Biomedical Mater Res Part A. 2015;103(3):981–9.

Li Y, Liu X, Tan L, Cui Z, Yang X, Yeung KWK et al. Construction of N-halamine labeled silica/zinc oxide hybrid nanoparticles for enhancing antibacterial ability of Ti implants. Materials science & engineering C, Materials for biological applications. 2017;76:50 – 8.

Trino LD, Albano LGS, Bronze-Uhle ES, George A, Mathew MT, Lisboa-Filho PN. Physicochemical, osteogenic and corrosion properties of bio-functionalized ZnO thin films: potential material for biomedical applications. Ceram Int. 2018;44(17):21004–14.

Hakim, L. K., Yari, A., Nikparto, N., Mehraban, S. H., Cheperli, S., Asadi, A., ... & Hasani Jebelli, M. S. (2024). The current applications of nano and biomaterials in drug delivery of dental implant. BMC Oral Health, 24(1), 126.

Published

15-01-2024

How to Cite

Alonazi, R. S., Alqubaysi, H. A., & Al-Mutairi, N. H. (2024). Biomaterials in dentistry: Advances in tissue engineering for dental restoration. International Journal of Health Sciences, 8(S1), 999–1015. https://doi.org/10.53730/ijhs.v8nS1.15035

Issue

Section

Peer Review Articles

Most read articles by the same author(s)