Innovative approaches in regenerative endodontics: A review of current literature

Bander Khalid Almoharib; Reem Saleh Alonazi; Mohammed Ali Alanazi; ‏Hissah Abdulkarim Alqubaysi; ‏Abrar Fayadh Alshammari; ‏Noor Abdulaziz Alzuhair; ‏Amal Alhumidy Alenizi; ‏Fatimah Ali Khormi; ‏Munifah Hamdan Alshammari; Saleh Zuwayel Alenezi; Albandari Khudhayr Alshammari

doi:10.53730/ijhs.v8nS1.15031

Authors

Bander Khalid Almoharib KSA, National Guard Health Affairs
Reem Saleh Alonazi KSA, National Guard Health Affairs
Mohammed Ali Alanazi KSA, National Guard Health Affairs
‏Hissah Abdulkarim Alqubaysi KSA, National Guard Health Affairs
‏Abrar Fayadh Alshammari KSA, National Guard Health Affairs
‏Noor Abdulaziz Alzuhair KSA, National Guard Health Affairs
‏Amal Alhumidy Alenizi KSA, National Guard Health Affairs
‏Fatimah Ali Khormi KSA, National Guard Health Affairs
‏Munifah Hamdan Alshammari KSA, National Guard Health Affairs
Saleh Zuwayel Alenezi KSA, National Guard Health Affairs
Albandari Khudhayr Alshammari KSA, National Guard Health Affairs

Keywords:

regenerative endodontics, biomimicry, cell homing, revascularization, pulp-dentin regeneration, scaffolds, gene therapy

Abstract

Background: Biomimicry or biomimetics refers to developing materials and techniques inspired by natural systems. In dentistry, this approach aims to replicate natural tooth structures and functions, addressing limitations of conventional materials and techniques. Regenerative endodontics, including cell homing and revascularization, represents significant advancements in this field, focusing on pulp-dentin regeneration and tooth vitality restoration. Aim: This review explores innovative biomimetic approaches in regenerative endodontics, including the latest techniques and their clinical implications. It aims to assess the effectiveness and future prospects of these methods in enhancing tooth repair and regeneration. Methods: The review synthesizes current literature on regenerative endodontic procedures, including cell homing, revascularization, scaffold implantation, and gene therapy. It examines experimental studies, clinical trials, and advancements in biomimetic materials and techniques, highlighting their applications and outcomes. Results: The review finds that regenerative endodontics has evolved from traditional apexification to advanced techniques such as cell homing and revascularization. Cell homing, which leverages the body’s natural healing processes without cell transplantation, shows promise in generating pulp-dentin tissue. Revascularization, involving the induction of a blood clot and stem cell recruitment, has demonstrated potential in restoring vitality to necrotic teeth.

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