Advancements in intelligent drug delivery systems and their clinical applications

Ibrahim Abdullah  Hamzy; Abdulelah Ibrahim Alqhoson; Anas Mohammed Aljarbou; Mohammed Abdulrahman Alhajri

doi:10.53730/ijhs.v1nS1.15092

Authors

Ibrahim Abdullah Hamzy KSA, National Guard Health Affairs
Abdulelah Ibrahim Alqhoson KSA, National Guard Health Affairs
Anas Mohammed Aljarbou KSA, National Guard Health Affairs
Mohammed Abdulrahman Alhajri KSA, National Guard Health Affairs

Keywords:

Drug Delivery Systems, Nanotechnology, Smart Polymers, Stimuli-Responsive Materials, Clinical Applications, Targeted Therapy

Abstract

Background: Intelligent Drug Delivery Systems (DDSs) have revolutionized the way medications are administered, aiming to enhance therapeutic efficacy while minimizing side effects. Conventional DDSs often lead to systemic drug distribution and uncontrolled release, causing undesirable side effects and suboptimal therapeutic outcomes. To address these limitations, advanced controlled DDSs, particularly those leveraging nanotechnology, have been developed to target specific sites with precise regulation. Aim: This review aims to explore the recent advancements in intelligent drug delivery systems, focusing on their design, mechanisms, and clinical applications. It highlights the role of nanotechnology in enhancing the specificity and efficacy of drug delivery through various stimuli-responsive mechanisms. Methods: The review synthesizes findings from recent studies on various smart drug delivery platforms, including nanoparticle-based systems, smart polymers, liposomes, and organic-inorganic hybrids. It evaluates these systems based on their responsiveness to internal stimuli (e.g., pH, redox reactions, enzymes) and external stimuli (e.g., temperature, light, magnetic fields), and their clinical applicability. Results: The review identifies several innovative DDSs that employ stimuli-responsive materials to control drug release. Notable advancements include pH-responsive nanoparticles targeting tumor cells, redox-responsive systems for cancer therapy, and temperature-sensitive liposomes used in hyperthermia.

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